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Research Article | DOI: https://doi.org/10.31579/2690-8794/239
Obstetrics and Gynecology, Dubai Health, Dubai, UAE.
*Corresponding Author: Nigar Mehtiyeva, Obstetrics and Gynecology, Dubai Health, Dubai, UAE.
Citation: Nigar Mehtiyeva, Laila Alhubaishi, Hanan Gharbi, Ethar M. Naza, (2026), The Interplay between Vitamin D deficiency and Polycystic Ovary Syndrome (PCOS), Clinical Medical Reviews and Reports, 8(1); DOI:10.31579/2690-8794/239
Copyright: © 2026, Nigar Mehtiyeva. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 25 December 2025 | Accepted: 16 January 2026 | Published: 28 January 2026
Keywords: vitamin D deficiency; polycystic ovary syndrome; PCOS; Vitamin D receptor; insulin resistance; inflammation; menstrual irregularities; hyperandrogenism; genetic factors; environmental factors; molecular mechanisms
PCOS is the most common endocrine disorder in the reproductive age group of women, and its prevalence is believed to range between 6-12% globally [1]. It has a broad range of clinical signs and symptoms, characterized by oligo and anovulation, hyperandrogenism, and polycystic ovaries morphologically, being is a complicated disorder with extensive effects on the reproductive, metabolic, and psychological systems [2]. To date, the exact etiology of PCOS is unknown, and multiple factors are assumed to be involved in the pathogenesis of PCOS, including genetic, environmental and hormonal factors [3].
In the past ten years, research has shown that low levels of vitamin D may increase the risk of developing polycystic ovary syndrome (PCOS) and can worsen its symptoms.
This is particularly important because vitamin D is a fat-soluble vitamin, a pro-hormone involved in various physiological aspects of the body, such as calcium balance, immune system function, and insulin level stability (4). It is well known that the biologically active form of vitamin D accomplishes its biological activities through the VDR, which is shown to be highly expressed in various tissues, including ovarian tissues [5]. This has, therefore, led to heightened concern in trying to determine the role of vitamin D in reproductive health with a focus on PCOS.
According to recent studies, low serum vitamin D levels have been linked to a major impact on the pathophysiology of polycystic ovarian syndrome (PCOS). Vitamin D insufficiency is common in women with PCOS, according to research by Karadağ et al. [6], and it is associated with harmful metabolic consequences like insulin resistance and hyperandrogenism. According to their research, vitamin D supplementation may help deficient PCOS patients' insulin sensitivity and androgen levels, which may reduce some symptoms. Similarly, vitamin D administration improves insulin resistance in PCOS-affected women by regulating hormonal imbalances such increased androgen levels, according to a meta-analysis by Łagowska et al. [7] When Cander et al. [8] examined the connection between vitamin D levels and insulin resistance, they discovered a substantial correlation between the two. This reinforces the idea that vitamin D deficiency may exacerbate PCOS, suggesting that addressing it could be crucial for effective management.
Vitamin D's effects on PCOS are claimed to operate through several pathways. Low vitamin D status has been suggested to be linked to a rise in insulin resistance, a feature of PCOS, since it is well known to have altered insulin sensitivity [9]. In addition, it has been evidenced that vitamin D has apparent effects on modulating the inflammatory processes, which are, by and large, abnormally activated in PCOS and lead to the state of chronically low-grade inflammation. There is also increasing data showing that vitamin D influences androgen synthesis and secretion [10]. Some of the evidence, like the work by Subashree et al. [11], suggests that vitamin D supplementation may be beneficial to reduce the high circulating levels of androgens in women and regulate the intermittent menstrual cycle in PCOS.
Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in women of reproductive age, primarily characterized by metabolic and reproductive abnormalities. Ample evidence has established vitamin D deficiency as a factor that widely exacerbates standard features in PCOS, such as insulin resistance, hormonal imbalance, and low-grade chronic inflammation. Gaining insight into such a relationship is also crucial for developing effective management Methods: PubMed, Google Scholar, Science Direct, and ResearchGate were used to conduct a systematic literature review, with data selection based on articles published between 2016 and 2024. The targeted criterion of the human studies on this association between vitamin D and PCOS has been clinical, molecular, genetic, and environmental aspects; the articles written in English involve animals and endocrine disorders that do not directly relate to the current subject. Discussion: A comparison of the literature reveals that there is a very high prevalence of vitamin D deficiency in women with PCOS that may worsen the conditions of insulin resistance, irregular menstrual cycles, hyperandrogenism, and systemic inflammation. Thus, vitamin D directly influences significant molecular processes related to insulin signaling, hormone synthesis, and immune regulation; these findings make this vitamin deficiency central to the disease's development. It has been found that several studies have demonstrated that the supplementation of vitamin D can enhance metabolic and reproductive performance. Nonetheless, the best ways to administer the doses and how long they should be taken are still unknown. Genetic and environmental factors with customized therapeutic approaches are needed to moderate the vitamin D predisposition for PCOS. Conclusion: Thus, another way of ensuring the promotion of vitamin D deficiency is through the enhancement of the management of PCOS. In further studies, the development of supplementation strategies and the identification of personal treatment regimens should be the focus. When optimized as a form of treatment, vitamin D could rank among the best approaches fit for enhancing the quality of life of women with PCOS and reducing the many health risks that come with this disease.
This systematic review used a systematic search strategy to identify studies on the association between vitamin D deficiency and PCOS. The primary rationale of this paper was to compile and synthesize the most current and relevant research findings to develop an advanced understanding of mechanisms, implications, and possible therapeutic approaches linked with this interaction.
Search Strategy and Keywords
Four major academic databases were searched for this review: PubMed, Google Scholar, ScienceDirect, and ResearchGate. The extensive coverage of peer-reviewed literature in the scientific and medical domains was a contributing factor in this selection. To make sure the papers obtained were current and indicative of the most recent advancements in this field, the search was limited to articles published between 2016 and 2024. The following keywords, when combined with Boolean operators, formed the basis of the search strategy: "vitamin D deficiency," "polycystic ovary syndrome," "PCOS," "Vitamin D receptor," "insulin resistance," "inflammation," "menstrual irregularities," "hyperandrogenism," "genetic factors," "environmental factors," and "molecular mechanisms." The search results were restricted to research that thoroughly examined the connection between vitamin D and PCOS using Boolean operators.
Inclusion and Exclusion Criteria
A strict approach was undertaken to select relevant studies based on high-quality research on the inclusion criteria. Emphasis was placed on studies relating vitamin D deficiency to PCOS in human populations and studies following recognized diagnostic criteria, such as the Rotterdam criteria, in diagnosing women with PCOS. This ensures that the findings are applicable to human health and clinically useful. In addition, only research published in English were taken into consideration in order to preserve the review's quality and dependability. For appropriate data interpretation and analysis, this criterion is necessary. Studies not directly relevant to the issue of interest, animal models, abstract-only publications, and other endocrine illnesses or conditions that potentially change the relationship between vitamin D and PCOS were among the exclusion criteria. By omitting additional cases, this strategy allowed the review to remain focused on the particular connection between vitamin D insufficiency and PCOS.
The sensitive search was followed by the meticulous application of inclusion and exclusion criteria to yield studies that best contribute to deepening the understanding of the role of vitamin D in PCOS. The literature review highlights the most relevant recent research. It thus provides critical insights into the possible mechanisms by which vitamin D influences the pathophysiology of PCOS and aspects related to therapy by addressing vitamin D deficiency in women with PCOS. These selected studies lay the groundwork for considering the integration of vitamin D supplementation in the clinical management of PCOS and may contribute to improved outcomes among those affected.
This review emphasises the common link between vitamin D insufficiency and women's polycystic ovarian syndrome (PCOS), emphasising how the shortage may worsen the disease's course. A worsening of the main symptoms of PCOS, such as insulin resistance, irregular menstruation, and hyperandrogenism, is associated with the deficit. In addition, the study examines the therapeutic potential of vitamin D supplementation and the complex interaction between vitamin D and insulin resistance in the context of PCOS.
1. Vitamin D and Insulin Resistance
Insulin resistance is quite common in patients with PCOS, and this is one of the aspects of the syndrome. This insensitivity is one of the factors that leads to obesity, dyslipidemia, and a higher risk of type 2 diabetes in women suffering from PCOS. The effect of vitamin D on insulin sensitivity has also initiated interest amongst many. Studies have found that women with insufficient vitamin D are likely to be more insulin resistant which will affect them negatively metabolically since they already have the PCOS health condition [6,7]. A review of the literature demonstrates that vitamin D has a role in gene expression and metabolic signaling pathways associated with insulin sensitivity, which has implications on metabolic health. The study conducted by Dastorani et al [9], suggests that vitamin D supplementation may enhance the metabolic status of women with PCOS to a relatively large extent. In this study, it has been determined that vitamin D supplementation improves insulin sensitivity and the pattern of lipid metabolism in infertile PCOS candidates for IVF. These results indicated that vitamin D supplementation has enhanced insulin sensitivity, and it goes further to reach a metabolic health domain of lipid profiles. Similarly, Zhao et al (12), showed that vitamin D supplementation interrupts insulin resistance in PCOS patients. Their studies noted that vitamin D helped increase insulin receptors and activity, which is crucial in glucose acceptance and metabolism.
These findings are further supported by Karadağ et al [6], who showed that in vitamin-D-deficient women with PCOS, insulin sensitivity was significantly improved after supplementation with vitamin D. In this context, plausible mechanisms for this favorable effect of vitamin D include modulation of calcium homeostasis and a reduction of inflammation. Chronic low-grade inflammation, which often accompanies PCOS, has been known to play a recognizable role in insulin resistance. The anti-inflammatory action of vitamin D is relevant in that context and may contribute to the attenuation of the inflammation processes, further promoting insulin resistance in women with PCOS.
Łagowska et al. [7], in their systematic review and meta-analysis, underlined the most relevant strategy for PCOS management, especially regarding insulin resistance, was related to modifications in lifestyle that aimed at increasing vitamin D levels. Indeed, their analysis underlined that an integrated approach, which includes dietary changes, increased sunlight exposure, and vitamin D supplementation, might have a cumulative effect on improving insulin sensitivity and metabolic health in PCOS patients. The community-based management of PCOS involves a comprehensive treatment strategy that focuses on addressing the syndrome at the grassroots level. This holistic method encompasses the management of vitamin D deficiency as part of a wider therapeutic framework.
Cander et al. [8], showed excellent evidence of the interaction between vitamin D and insulin resistance in PCOS. They demonstrated that lower levels of vitamin D in serum were significantly related to higher levels of insulin resistance, thus indicating a direct relationship between vitamin D status and metabolic health in women with PCOS. These findings support that proper vitamin D levels are necessary for metabolic homeostasis and could contribute to reducing the risk of associated complications such as type 2 diabetes. Collectively, these investigations indicate that supplementation and behavioral interventions for vitamin D deficiency could offer a novel, promising strategy for the pharmacological administration of insulin resistance in women with PCOS. These studies suggest that vitamin D can potentially reverse staging and management of metabolic syndrome in terms of different diabetes complications such as type 2 diabetes.
2.Menstrual Irregularities and Hyperandrogenism
Menstrual irregularities and hyperandrogenism are the hallmark features of PCOS, which significantly affect the reproductive health and quality of life of the affected individual. The role of vitamin D in such symptom management has thus become one of interest, for which many studies look onward to its effect on menstrual regularity and androgen levels.
A systematic review and meta-analysis were conducted by Guraya and Alzobydi [13], addressing the association between hypovitaminosis D and PCOS. Their findings emphasized the role of vitamin D in ameliorating menstrual disturbances and hyperandrogenism, a deficiency that could further aggravate these two essential features of PCOS. Similarly, Karadağ et al. [6], in their research article, demonstrated that supplementation with vitamin D significantly improved insulin sensitivity and androgen levels among vitamin D-deficient women with PCOS. The study justifies the argument that supplementation with vitamin D may present a new therapeutic strategy for menstrual irregularities and hyperandrogenism in PCOS.
In addition, Subashree et al. [11] assessed the correlation between serum calcium and vitamin D and hormonal status in females with PCOS. They also pointed out that such a level was significant in women with this condition, and their results suggest that increased serum calcium and vitamin D levels are associated with improved hormonal profiles. This finding suggests vitamin D could play a role in the symptomatic management of PCOS. A cross-sectional study by Shan et al. [14], demonstrates that subnormal vitamin D levels are linked with hyperandrogenaemia among women affected by PCOS - an essential component of the relationship between vitamin D status and levels of androgens. This would, therefore, point to the fact that vitamin D might be centrally involved in the regulation of hyperandrogenism in women with PCOS.
3. Inflammation and Immune Modulation
One of the hallmarks of PCOS is chronic, low-grade inflammation, which is considered a significant factor in its pathogenesis. On the other hand, vitamin D deficiency is common among patients with PCOS and tends to promote an inflammatory state toward further metabolic and reproductive derangements. Vitamin D is well-recognized for its immunomodulatory effects, which play a critical role in modulating immune responses via suppression of inflammation. Hussein [15], performed a systematic review that underlined the supplementation with vitamin D as a strategy that might mitigate systemic inflammation and improve metabolic outcomes among women with PCOS.
The results support that vitamin D could help minimize chronic inflammation associated with the condition, providing a promising therapeutic option to help manage this complex condition. In this context, Guo et al. [10], pointed out the anti-inflammatory role of vitamin D. They suggested that supplementation with this vitamin may modulate the immune response and reduce oxidative stress, which is all part of the hallmark feature of PCOS pathophysiology.
Vitamin D supplementation, among other nutritional supplementation, on oxidative stress and hormonal balance was assessed by Sidabutar et al. [17], among PCOS women. The results indicated significant reductions in oxidative stress markers, coupled with an improvement in metabolic health following supplementation with vitamin D, thus pointing to the potential of vitamin D in countering inflammation processes associated with PCOS. These findings are essential since chronic inflammation enhances insulin resistance-a cardinal feature of the syndrome-and increases the risk for cardiovascular complications. The role of vitamin D in the pathophysiology may thus be essential for improving both metabolic and reproductive outcomes in women with PCOS through its anti-inflammatory and antioxidant effects [5,10,12]. While the data to date are encouraging, further research is needed to clarify, first, the actual mechanisms of the anti-inflammatory action of vitamin D and, second, the establishment of optimal treatment protocols that would result in reasonable control of the inflammatory process in PCOS patients [1,3].
4. Genetic and Environmental Factors
In parallel to inflammation, the vitamin D status of women with PCOS is determined by the combination of genetic profile and environmental factors. In this regard, Shi et al. [19], carried out a meta-analysis investigating the correlation between variations in the vitamin D receptor gene and polycystic ovarian syndrome (PCOS). They emphasized how some VDR gene variations, including VDR ApaI (rs7975232) and VDR BsmI (rs1544410), are connected to an increased risk of PCOS via pathways including metabolic dysregulation and insulin resistance. These polymorphisms may also impact blood parathyroid hormone and 25-hydroxyvitamin D levels via influencing the PTH-vitamin D axis. Significantly, the correlation differed by ethnicity, showing that environmental variables and VDR polymorphisms combine to cause PCOS in Asian populations but not in Caucasian ones.
Additionally, Morgante et al. [20], talked about the complex nature of PCOS, noting that it affects between 10 and 15 percent of women of reproductive age, with prevalence varied depending on geographic circumstances and diagnostic criteria. They emphasized the importance of lifestyle and environmental factors in obesity and insulin resistance (IR), which is an essential hallmark of PCOS, particularly in obese people. Geographical location influences the synthesis of vitamin D (VD), which is produced by exposure to UV radiation, and may have an effect on vitamin D levels in women with PCOS. The scientists also noted elevated oxidative stress markers in PCOS patients, which are impacted by diet and lifestyle. They discovered a negative relationship between serum vitamin D levels and body mass index (BMI), suggesting that obesity, which is frequently made worse by environmental factors, is associated with reduced vitamin D status and increased insulin resistance in women with PCOS[20].
Again, this highlights the importance of taking into account both hereditary and environmental factors when managing PCOS because of their interplay in determining the severity of symptoms and the effectiveness of treatment.
5. Molecular Mechanisms
Studies also show the presence of biochemical pathways that connect vitamin D insufficiency to PCOS. Subashree et al. (11) point out that 4–16% of women of reproductive age have PCOS, which frequently coexists with insulin resistance and compensatory hyperinsulinemia. According to their research, vitamin D plays a key role in controlling important genes linked to inflammation, steroidogenesis, and insulin signaling, which greatly contributes to the pathophysiology of PCOS. The results indicate that in addition to its regulatory function in calcium metabolism, which is necessary for efficient insulin release, vitamin D may also affect insulin secretion through processes like the activation of insulin gene transcription. Furthermore, the immunomodulatory properties of vitamin D help reduce inflammatory reactions, which are known to put people at risk for insulin resistance, a defining feature of PCOS.
Additionally, the effect of vitamin D on insulin levels is highlighted among women with PCOS, with studies showing that low levels of vitamin D are detrimental to insulin metabolism, supporting the cause of insulin receptor sensitivity. There is a strong case for vitamin D therapy, as it has been shown to ameliorate obesity-induced insulin resistance, hormonal alterations, and dyslipidemia, which are common features in women with PCOS (11).
A thorough meta-analysis performed by Zhao et al. [12], examined the use of vitamin D as a possible treatment for PCOS, emphasizing its essential function in regulating gene expression, maintaining hormonal balance, and modulating inflammatory pathways associated with the disorder's pathophysiology. The study showed that vitamin D supplementation may positively affect total testosterone levels, inflammatory markers such as hs-CRP, and oxidative stress indicators like TAC and MDA. These findings further indicates that vitamin D alters important molecular mechanisms related to PCOS, such as insulin resistance and hyperandrogenism, which may be crucial in managing the condition. Understanding these complex molecular interactions can lead to more effective therapeutic interventions aimed at addressing the underlying abnormalities in PCOS, where the potential for personalized treatment strategies derived from individual molecular profiles presents promising opportunities for enhancing health outcomes in women affected by the condition.
6. Therapeutic Implications
Although the therapeutic role of vitamin D supplementation has immense potential in managing PCOS, much remains to be sorted out to get the full beneficial effect of its supplementation. Most existing studies have demonstrated favourable effects, primarily on improving metabolic dysfunction, however, determining the optimum dosage and duration of supplementation is still a significant challenge. Zhao et al. [12], indicated that further study was warranted to determine the appropriate supplementation protocols and long-term effects of vitamin D on the management of PCOS. This shows that large-scale RCTs must be conducted to establish standards that ensure that supplementation with vitamin D is both practical and safe for clinical practice.
Guo et al. [10], also pointed out the potential role of vitamin D in improving metabolic parameters among women suffering from PCOS. In this regard, the systematic review undertaken by these authors analysed a wide array of randomized controlled trials. It demonstrated how vitamin D improves outcomes for such patients and illustrated that using a standardized supplementation method could have valuable effects in improving such outcomes. Furthermore, Karadağ et al. [6], emphasized that treatment plans must be individualized to suit the different hormonal and metabolic variables in PCOS patients. This personalized approach ensures treatment strategies are at their best in resolving individual patient needs against variable and heterogeneous PCOS presentations.
Further, Bashir et al. [18] reiterated that vitamin D status needs to be addressed as an essential component in managing PCOS. When incorporated into clinical practice, all these help healthcare providers provide better and more personalized management to women with PCOS.
In conclusion, this literature review underscores the significant association between vitamin D deficiency and polycystic ovary syndrome (PCOS), highlighting the multifaceted role of vitamin D in the pathophysiology of this complex disorder. The evidence suggests that low vitamin D levels are prevalent among women with PCOS and may exacerbate key symptoms such as insulin resistance, hyperandrogenism, and menstrual irregularities. The therapeutic potential of vitamin D supplementation emerges as a promising avenue for managing these symptoms, with studies indicating improvements in metabolic health and hormonal balance. Moreover, the interplay between genetic and environmental factors further complicates the relationship between vitamin D and PCOS, suggesting that personalized treatment approaches may be necessary to optimize patient outcomes. While current research provides a solid foundation for understanding the implications of vitamin D in PCOS, further studies are warranted to elucidate the underlying mechanisms and establish standardized supplementation protocols. Ultimately, addressing vitamin D deficiency should be considered an integral component of the clinical management of PCOS. By incorporating vitamin D supplementation and lifestyle modifications into treatment plans, healthcare providers may enhance the quality of life for women affected by this condition and mitigate the risk of associated metabolic complications. Continued research in this area is essential to refine therapeutic strategies and improve the overall management of PCOS.
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Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
