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Research Article | DOI: https://doi.org/10.31579/2690-1919/576
1Departement of Histopathology, Faculty of Medicine and Health Sciences, Sana’a University, Republic of Yemen.
2Department of Basic Sciences, Faculty of Dentistry, Sana’a University, Republic of Yemen
3Medical Microbiology and Clinical Immunology Department, Faculty of Medicine and Health Sciences, Sana’a University, Republic of Yemen.
4Oral and maxilla-facial surgery Department, Faculty of Dentistry, Sana’a University, Republic of Yemen.
*Corresponding Author: Hassan A. Al-Shamahy Department of Basic Sciences Faculty of Dentistry Sana’a University Republic of Yemen.
Citation: Amin A. Okbah, Yahya Rajeh SA, Taghreed Ahmed Al-kibsi, Al-Shamahy HA, Emad Hassan Al-Shamahi, et al, (2025), Prevalence of Oral Irritation Fibroma and Associated Risk Factors in Sana’a City, J Clinical Research and Reports, 21(4); DOI:10.31579/2690-1919/576
Copyright: © 2025, Hassan Abdulwahab Al-Shamahy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 02 September 2025 | Accepted: 28 October 2025 | Published: 03 November 2025
Keywords: benign tumors; irritation fibroma;oral cavity's mucosa; prevalence; risk factors; sana'a city; yemen
Background and aims: On the oral cavity's mucosa, irritation fibroma is one kind of fibroma. Common benign tumors called irritation fibromas are asymptomatic and mimic scarring. Prolonged oral irritation, including biting of the cheek or lip, tooth rubbing, and dental prostheses, is the cause of them. The study's objective was to find out how often irritation fibroma and its contributing factors were in a sample of Yemeni dentistry patients in Sana'a City.
Method: A study examined 1,485 Yemeni patients at dental clinics, collecting demographic data, risk factors, dental history, and habits. Patients underwent clinical examinations and intraoral examinations, with oral lesions detected through intraoral examinations. If any tumors were found, patients were referred for histological examination. The data was anaAlyzed and tabulated.
Results: The study included 589 females and 898 males, with a mean age of 35.97±13.9. Most patients were aged ≤15, with married patients comprising 36% and single patients comprising 60%. Occupations were primarily employee, students, workers, and housewives. Irritation fibroma is most common in the age group 36-45 years, with 19.4% of cases. It is more prevalent in individuals aged 26-35 years, 4.2% in those over 56 years, 2.9% in 46-55 years, and 2.8% in young adults. Irritation fibroma is more prevalent in males, with a frequency of 5.02%, indicating a significant association with male sex. Age group 36-45 years also shows a higher prevalence of 6.4%, with an associated odds ratio of 1.9 times. Qat chewing and smoking were found to be risk factors for Irritation fibroma, with an OR of 2.6 times and 2.5 times respectively. Tooth grinding, cheek biting, and poor mouth hygiene are risk factors for the development of Irritation fibroma. Tooth grinding is 10 times more likely to cause the condition, while cheek biting is 14.2 times more likely. Poor mouth hygiene is 1.6 times more likely. The study found that depopulated tongue, gingivitis history, and periodontitis were significant risk factors for the development of Irritation fibroma lesions, with a significant OR of 4.7 times and 15.4 times respectively.
Conclusion: In the current study, irritant fibroma lesions were very common among patients attending dental clinics in Sana’a city. Compared with males, the prevalence of lesions in male patients was higher than females, and older age groups were more likely to develop oral irritation fibromas lesions but even children there was detectable prevalence of irritaion fibromas.
One kind of fibroma that develops on the oral mucosa is called an irritant fibroma [1]. Common benign tumors that resemble scars and are asymptomatic are called irritant fibromas. They are brought on by chronic oral discomfort, including dentures, teeth grinding, and biting of the cheek or lip. Fibromas are smooth, hard, and fibrous; they may be lighter in color than the oral mucosa, but they are typically the same. Their color may be darker if they are injured. They typically occur alone and do not progress to mouth cancer. Irritating fibromas usually exhibit thickening of the stratum corneum (hyperkeratosis) and hyperplasia (hyperplasia) in their epidermis [2]. They frequently have clear edges and develop extrinsically from the surface. They can have a solid or pedunculated base [3].They rarely develop larger than one and a half centimeters in diameter, and their growth is sluggish and painless, taking months or years. They are a localized increase of connective tissue rather than actual tumors. In the dermis of irritating fibromas, histology reveals dilated blood vessels, a proliferation of mature fibroblasts, and thick collagen fibers. Infiltration of inflammatory cells is either negligible or nonexistent. Clinical characteristics are used to suppose irritant fibromas [4], however histological examination (such as biopsy [1]) may be carried out. Irritating fibromas can be treated by surgical excision.Although recurrence is rare, it can occur if the irritant persists [3]. As a result, treating the root problem is crucial [1]. If irritant fibromas are not treated, they do not go away on their own. Although they can develop at any age, irritant fibromas are more prevalent in the elderly [1]. especially people in their 50s and 60s [1]. In females, they are twice as prevalent. In adults, the condition affects one to two percent of people. Furthermore, because the gingiva is continuously exposed to irritants including food particles, tartar, dental plaque, broken fillings, and uncomfortable brushing, a large number of oral mucosal lesions are reactive. Persistent inflammation brought on by chronic irritation can promote the growth of endothelial cells and chronic inflammatory cells [6–8]. Even though our study found a considerable frequency among youngsters, fibroma is one of the most common benign soft tissue tumors of the oral cavity in adults. This tumor, which is classified as a reactive hypertrophic lesion, presents clinically as impaired tissue repair as a result of persistent oral mucosal irritation [9–12]. An imbalance of the forces that ordinarily hold teeth in place can also result from this lesion, a process known as pathological tooth migration [13,14]. Irritant fibromas can develop centrally (intraosseously) inside the jaws or on the soft tissues of the oral cavity, including the tongue, gingiva, etc. Lesions of irritant fibroma are more commonly observed on the tongue, buccal mucosa, gingiva, and alveolar ridge. The floor of the mouth and the hard palate are less frequently involved [15–17]. This study's objective was to determine the prevalence of oral irritant fibroma lesions and the factors that were linked to them in a sample of Yemeni dentistry patients in Sana'a.
Study design: An observational cross-sectional clinical study.
Study population: The dental clinics at Sana'a University, Alrazi University, Alyemenia University, Aljomhori, and Althawra Hospital comprise a sample of Yemeni patients.
Inclusion criteria: Adults and children over 5 years Yemeni dental patients.
Exclusion criteria: Children below 5 years, edentulous patients and non-Yemeni patients.
Sample size calculation: All patients visiting the oral medicine department of the three universities and few private dental clinics between February 2025 and June 2025 were included, according to the predetermined inclusion criteria.
Method of data collection:
Examined were 1,485 Yemeni patients who visited the chosen dental clinics, 896 of whom were men and 589 of whom were women. All participants gave their informed consent, and each patient's relevant data was recorded using a data collecting routine. Risk factors and demographic information were gathered before the clinical assessment. Additionally, information about prior dental procedures, any subpar restorations, and their location were confirmed. Additionally noted were behaviors like smoking, snuff use, chewing qat, teeth grinding, cheek biting, and poor oral hygiene. In a dental chair, participants got an intraoral examination and an additional clinical evaluation. An intraoral examination of soft tissues was performed, and if any oral lesions were found, the patient was referred to hospitals for histological examination to determine the tumor type. After collecting the information and laboratory results, the data were analyzed and tabulated.
Ethical considerations: Formally, Sana'a University No. (263), the Medical Ethics Committee of the Faculty of Dentistry, granted ethical permission. Every participant in the study gave their consent after permission to evaluate the patients was requested.
Examined were 1,485 Yemeni patients who visited the chosen dental clinics, 896 of whom were men and 589 of whom were women. All participants gave their informed consent, and each patient's relevant data was recorded using a data collecting routine. Risk factors and demographic information were gathered before the clinical assessment. Additionally, information about prior dental procedures, any subpar restorations, and their location were confirmed. Additionally noted were behaviors like smoking, snuff use, chewing qat, teeth grinding, cheek biting, and poor oral hygiene. In a dental chair, participants got an intraoral examination and an additional clinical evaluation. An intraoral examination of soft tissues was performed, and if any oral lesions were found, the patient was referred to hospitals for histological examination to determine the tumor type. After collecting the information and laboratory results, the data were analyzed and tabulated.
Ethical considerations: Formally, Sana'a University No. (263), the Medical Ethics Committee of the Faculty of Dentistry, granted ethical permission. Every participant in the study gave their consent after permission to evaluate the patients was requested.
The number of females was 589 (39.7%) and males 898 (60.3%), with 147 (9.9%) of patients aged ≤ 15 years, 287 (19.3%) aged 16-25 years, 277 (18.7%) aged 26-35 years, 298 (20.1%) 36-45 years, 240 (16.2%) aged 46-55 years and 236 (15.9%) of patients aged ≥56 years. The mean age ± SD was 35.97±13.9 (Table 1).
Table 1: Sex and age distribution of patients presenting to oral medicine departments for investigation of Irritation fibroma.
Married patients comprised 535 (36%), while single patients comprised 891 (60%) and widows were 59 (4%). Regarding occupations, most patients were employee (455) (30.6%), students (453) (30.5%), followed by workers (304) (20.5%), housewives (178) (12%), while other occupations were less common (Table 2). Most Irritation fibroma occurred in the age group 36-45 years, with 19 cases (6.4%) of the total, followed by 26-35 years with prevalence rate equal to 5.4% (15 cases), while only 2 cases (1.4%%) were in the age group ≤15 years (children). Also, the rate of irritation fibroma was 4.2% in ≥56 years, and 2.9% in 46-55 years. In young adults (16-25 years) the rate was 2.8%. Regarding gender, most Irritation fibroma occurred in males, with 45 cases (5.02%) of the total, while only 16 cases (2.72%) were in females (Table 2).
Table 2: Distribution of social and occupational status of patients presenting to oral medicine departments for investigation of Irritation fibroma.
The correlation between age, sex, and the prevalence of Irritation fibroma is displayed in Table 4. In male sex, the frequency of Irritation fibroma was higher than in females. For males, it was 5.02%, with an associated odds ratio (OR) of 1.8, a confidence interval (CI) of 1.1– 3.4, and X2 =4.7, with a p-value of 0.01. This indicates that the correlations and ORs were present with males, concluding that there is a significant association between Irritation fibroma and male sex. Regarding age, the prevalence of Irritation fibroma was higher in age group 36-45 years, reaching 6.4%, with an associated OR of 1.9 times, a CI of 1.1– 3.2, with a significant X2 of 4.9, and a p-value of 0.02 (Table 3).
Irritation fibroma=IF
Table 3: Association between sex, age, and incidence of Irritation fibroma.
Table 4: The relationship between Irritation fibroma and personal behaviors such as oral hygiene, qat consumption, Shammah, and smoking; and the incidence of oral and dental diseases.
Table 4 illustrates the correlation between the occurrence of oral and dental disorders and Irritation fibroma lesions as well as personal activities like smoking, qat usage, oral cleanliness, and Shammah. An associated odds ratio (OR) of 2.6 times, a confidence interval (CI) of 1.5-4.4, a significant X2 coefficient of 13.2, and a P value of 0.0002 were found when qat chewing was examined as a risk factor for Irritation fibroma. Also, smoking was an associated risk factor for developing Irritation fibroma, in which the OR was 2.5 times, with a confidence interval (CI) of 1.5-4.4, with a significant X² coefficient of 11.7 and a P value of 0.0006. Tooth grinding was a risk factor associated with the development of Irritation fibroma with an OR of 10 times, confidence interval (CI) of 4.3-26.9, with a significant X² coefficient of 38.8 and P value < 0>
In Yemen, routine dental clinics and hospitals routinely encounter oral neoplastic lesions, such as reactive benign prosthetic hyperplasia (BPH), in the oral mucosa [17,15,18-21]. When a patient comes to an outpatient dental clinic for routine care, these lesions may be symptomatic or discovered by chance. Numerous factors, including age, gender, the extent of irritation or damage, lesion type, and distribution, influence how these lesions manifest clinically [16]. The most prevalent risk factors include chronic low-grade inflammation, frequent chronic irritation from plaque and tartar buildup, biting of the cheek, hormonal imbalances, and exogenous trauma from things like loose fillings, sharp edges of broken teeth, and poorly fitting dentures [15, 22]. Severalresearches have been carried out to gather epidemiological data on oral cavity lesions or neoplastic lesions in general in Yemen [15,18-20,23-29]. Statistics on benign irritant fibromas, which are lesions of the oral mucosa that can lead to recurrent issues like poor masticatory function or cosmetic dissatisfaction, have not, however, received much attention.Males were more likely than females to have irritant fibroma in the current study. The correlations and ORs were present with males, indicating a significant association between male sex and irritation fibroma. For males, it was 5.02%, with an associated odds ratio (OR) of 1.8, a confidence interval (CI) of 1.1–3.4, and X2 =4.7, with a p-value of 0.01. This current data contrasts with that published in Brazil, where Kamile LD et al. [30] discovered that the prevalence of these irritant fibroma oral lesions is 2.5:1 higher in females than in males.
Additionally, our sex distribution is different from that of Da Saliva et al. in Nigeria [31] and Soyele OO et al. [32] in Brazil, where the majority of irritant fibroma oral lesions were recorded in females as opposed to males, with ratios of 2:1, 1.8:1, and 1.4:1, respectively [31, 32]. Lesions were also shown to be more common in women than in men (2.2 times higher) in research by Sangle et al. [33], Kadeh H et al. [34], and Ala Aghbali [35], which is in line with the findings of all the other studies cited [33,34,35]. It is possible that hormones play a predisposing role in the formation of these lesions, which explains why they are more common in female patients globally. Additionally, in Iran, Nigeria, and Pakistan, women visit dental clinics more frequently than males for examinations and treatment, which may reflect their increased concern for oral hygiene outside of Yemen. Men in Yemen, however, can be just as concerned about their dental health as women are, if not more so.
According to the current study, the age group of 36–45 years old had a greater prevalence of irritant fibroma (6.4%), with an associated OR of 1.9 times, a CI of 1.1–3.2, a significant X2 of 4.9, and a p-value of 0.02. Similar findings were reported by Ayaz M et al. in Pakistan [36], Kadeh et al. in Iran [37], Kumar et al. [38] in India, Halikiri et al. [39], and Awange et al. in India [40], where the mean age was 30 years lower than our mean age of 35 years and there was a high incidence of oral irritation fibroma lesions in the second and third decades. Our findings, however, contrast with those of Soyele O et al.25, who discovered that oral irritation fibroma lesions occur in a broad age range, from 10 to 70 years, with a higher prevalence in the fifth, sixth, and seventh decades of life.
In the current investigation, only two cases (1.4%%) of irritant fibroma occurred in the age range ≤15 years (children), whereas the majority (6.4%) occurred in adults (36–45 years). There is a dearth of data on the frequency of reactive hyperplasias in children, particularly with reference to irritant fibroma. Few studies have been published to date, and the results vary greatly, likely because the criteria used—such as age range and type of injury—as well as because the nations included in the studies varied geographically and endemically [41–44]. - Nonetheless, it has been established that reactive lesions are uncommon in children under the age of fifteen, especially in primary dentition, and that children are more likely to present giant cell fibromas than irritation fibromas, which in turn are more common in adult patients [9,45]. An associated odds ratio (OR) of 2.6 times, a confidence interval (CI) of 1.5-4.4, a significant X2 coefficient of 13.2, and a P value of 0.0002 were found when khat chewing was investigated as a risk factor for oral irritation fibroma lesions in the current study. Additionally, smoking was linked to an increased risk of irritant fibroma, with an OR of 2.5 times, a CI of 1.5-4.4, a significant X2 coefficient of 11.7, and a P value of 0.0006. It has been established that smoking and chewing qat are significant stimulants of the development of oral irritation fibromas lesions. Compared to other reactive lesions, patients with RHLs have a greater smoking incidence, according to DaSilva et al. [31]. A thorough histological assessment and verification of the lack of an infected lesion base are crucial for preventing recurrence. Additionally, patients and dentists should work to limit manageable stressors like smoking and chewing khat. With an OR of 10 times, a significant X2 coefficient of 38.8, a CI of 4.3-26.9, and a P value < 0>
Because exposure and outcome are only measured once, cross-sectional technique makes it challenging to draw causal relationships. This kind of study is prone to bias because of the brief time frame for data collection and the fact that it only looks at one area of Yemen.
Urgent action is now needed to stop the incidence and progression of oral irritation fibroma lesions, which are becoming more common in Yemen and around the world. This can be accomplished simply by offering patients who visit the dental clinic for regular examinations or any kind of dental treatment education seminars on good oral hygiene. The significance of keeping good oral hygiene and excellent appearance for a better and healthier life is typically unknown to those without access to dental care. Additionally, older age groups were more vulnerable with a higher incidence rate of oral irritant fibroma lesions, and female patients had a lower frequency of the lesions than male patients.
The authors would like to thank the National Public Health Laboratories, Al-Mamoon Center, and Al-Awlaqy Lab Centers in Sana’a city for their kind cooperation.
There are no conflicts of interest in regard to this project.
Amin Abdulkarem Okbah and Shama’a Rajah: formal analysis, conceptualization, data organization. All other authors supervised the work, reviewed the article and approved the final version.
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Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
