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Review Article | DOI: https://doi.org/10.31579/2693-7247/236
Department of Pharmaceutics, H. SBPVT, GOI, Faculty of Pharmacy, Kasthi.
*Corresponding Author: Saurabh Gaikwad, Department of Pharmaceutics, H. SBPVT, GOI, Faculty of Pharmacy, Kasthi.
Citation: Saurabh Gaikwad, Snehal Kadam, Sonal Solanki, Sunil Nirmal, (2025), Orally Disintegrationg Tablet; A Novel Approches to Enhanced Patient Compliance, J. Pharmaceutics and Pharmacology Research, 8(3); DOI:10.31579/2693-7247/236
Copyright: © 2025, Saurabh Gaikwad. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 03 June 2025 | Accepted: 18 June 2025 | Published: 27 June 2025
Keywords: orodispersible tablets; eletriptan hydrobromide; migraine; direct compression; disintegration time
Mouth dissolving tablets (MDTs) are an innovative oral dosage form designed to disintegrate rapidly in the mouth without the need for water. These tablets offer significant advantages, including ease of administration, improved patient compliance (particularly for pediatric and geriatric populations), and faster onset of action. MDTs are characterized by their pleasant taste, quick disintegration, and convenience, making them a preferred alternative to traditional tablets and capsules. They are widely used in various therapeutic areas such as pain management, allergy relief, and mental health. Compared to conventional oral dosage forms, MDTs provide enhanced patient experience, though they may have some limitations in terms of cost and formulation challenges. This review highlights the benefits, applications, and patient perspectives on MDTs while comparing them with other dosage forms. Future advancements in MDT technology may further expand their therapeutic potential.
Mouth dissolving tablets are solid dosage forms that quickly break down in the mouth, dissolving into saliva without needing water. The oral cavity is an attractive site for administration due to its ease of use. These tablets have gained popularity over the past decade for their convenience, dissolving quickly in the mouth without chewing or additional water(1). They're known by various names, including fast-dissolving, rapid-melting, and oro-dispersible tablets. According to the European Pharmacopeia, oro-dispersible tablets should disperse in the mouth within three minutes, making them easier to swallow(2). Good mouth dissolving tablets typically dissolve within seconds to a minute. With the high cost of developing new drugs, pharmaceutical companies are focusing on creating more patient-friendly and cost-effective dosage forms for existing medications(3).
Additionally, patients travel with minimal to no water surplus. Limit the effectiveness of oral administration of convectional tablet capsules. A tablet that dissolves in the mouth has a quick onset of action and is quickly absorbed. Furthermore, drug candidates that are formulated as mouth-dissolving tablets and undergo pre-gastric absorption may exhibit high oral bioavailability. It is easy to manufacture and offers precise dosing and good stability. When making mouth-dissolving tablets, synthetic super disintegrants like crospovidone, croscarmellose sodium, sodium starch, glycolate, and others are utilized. This method allows the tablet to dissolve in the tongue and release the medication into the saliva (4). When developing a formulation for such tablets, the appropriate choice of super disintegration and its consistency of performance are crucial factors to consider. By resolving earlier administrative issues and extending patent life, mouth dissolving drug delivery systems have secured a significant place in the market. As soon as the dosage forms come into contact with saliva, even within 60 seconds, they dissolve and disintegrate quickly, releasing the drug (5). It is particularly attractive to bedridden, elderly, and pediatric patients as well as active, busy, and traveling patients who might not have access to water because it does not require water during administration (6).
Dysphagia patients and older adults. One study found that size was the primary cause of swallowing difficulties for 26% of the 1576 patients, followed by shape, surface, and testes 8, 9.Solid dosage forms that can be chewed, dissolved and suspended in water, or rapidly dissolved in the mouth are especially in demand in the pediatric and geriatric markets. (7). These forms can also be used for other patients who would rather have a convenient, easily administered dosage form. Due to the fact that the average lifespan of humans has increased and that it is decreasing with age, Oral tablet administration to patients is a major issue in swallowing ability and has drawn public attention. The development of oral forms that dissolve or disperse quickly and don't need water to help with swallowing can solve the issue (8). After being put in the mouth, the dosage forms are swallowed normally after being given time to dissolve or spread in the saliva. They are less commonly made to be absorbed as saliva enters the stomach through the esophageal and buccal mucosa. In the latter instance, a drug's bioavailability from fast-dissolving formulations might even surpass that of conventional dosage forms (9),(10).
Ideal Characteristics of Mouth Dissolving Tablet
• It shouldn't need water or any other liquid to function.
• It feels good in your mouth.
• Be portable without worrying about fragility and compatible with taste masking.
• The recipients' wet ability should be high.
• After taking the tablet, there shouldn't be any residue in the mouth.
• It is less affected by environmental factors like temperature and humidity.
• The drug is absorbed from the pre-gastric route more quickly.
• The equipment used for processing and packaging is inexpensive.
• Permit a high drug loading (11).
Advantages of Mouth Dissolving Tablet over traditional oral dosage forms
• Faster Drug Absorption and Quicker Effects - Since MDTs disintegrate quickly in saliva, the drug is absorbed rapidly through the oral mucosa or stomach. Some medications bypass liver metabolism, leading to a faster onset of action useful for emergencies like heart pain or migraines.
• No Water Required for Administration - These tablets are ideal for people who struggle with swallowing, such as children, elderly patients, or those with dysphagia. They are also convenient when water isn’t easily accessible .
• Improved Drug Bioavailability - Some drugs break down in the stomach or lose potency due to liver metabolism. MDTs that dissolve in the mouth can avoid first-pass metabolism, increasing the drug’s effectiveness.
• Flexible Use for Different Treatments -MDTs are useful for,Emergency drugs (e.g., nitroglycerin for angina), Nausea/vomiting cases (where swallowing is hard), Psychiatric medications (for patients who resist treatment) (12).
Therapeutic Application
| Therpetic Category | Drug | Advantages | ||
| Neurological | Risperidone, Olanzapine, Clonazepam | Improves compliance in resistant patients, rapid absorption (13) | ||
| Cardiovascular | Nitroglycerin, Nifedipine |
| ||
| Pain /Fever | Paracetamol, Tramadol | Quick migraine relief, pediatric-friendly (14) | ||
| Allergy | Fexofenadine, Levocetirizine | Rapid relief, no water needed | ||
| Gastrointestinal | Ondansetron, Lansoprazole | Effective for chemo-induced nausea | ||
| Endocrine | Voglibose, Metformin
| Controls postprandial glucose (15)
|
Table 1: Therapeutic Application Of MDS
Mouth-dissolving tablets have become increasingly valuable in managing modern health challenges. For Long COVID symptoms like brain fog and fatigue, fluvoxamine and montelukast ODTs offer rapid relief while bypassing swallowing difficulties (16). In pediatric ADHD, methylphenidate and guanfacine ODT It improve compliance without choking risks. Post-stroke patients with dysphagia benefit from donepezil and clopidogrel ODTs, ensuring neuroprotection despite swallowing impairments. For dementia-related agitation, risperidone and memantine ODTs reduce medication refusal while providing rapid calming effects (17) . In chemotherapy-induced nausea, olanzapine and aprepitant ODTs are critical when vomiting prevents pill. Migraine sufferers rely on rimegepant and zolmitriptan ODTs (e.g., Nurtec®) for fast relief during nausea Even diabetes management leverages voglibose and metformin ODTs to control post-meal spikes These innovations highlight MDTs' role in enhancing compliance, speed, and accessibility in modern therapy (18) .
MDS Comparison with other Dosage Form
Pharmaceutical dosage forms have evolved significantly to improve patient compliance and therapeutic efficacy. Among these advancements, mouth-dissolving tablets (MDTs), also known as orodispersible tablets (ODTs), represent a notable innovation over conventional tablets. Unlike traditional tablets that require water for swallowing, MDTs are designed to rapidly disintegrate in the oral cavity, releasing their active ingredients quickly., typically within seconds, making them particularly advantageous for pediatric, geriatric, and dysphagic patients. This comparison highlights the key differences between these two dosage forms in terms of administration, formulation, patient suitability, and clinical applications. The following table provides a detailed side-by-side analysis of their distinct characteristics (19)
| Approaches | Mouth-Dissolving Tablet | Traditional Tablet | Capsule | Liquid (Syrup/Suspension) |
| Administration | Dissolves in mouth (no water needed) | Swallowed with water | Swallowed with water | Pre-measured oral ingestion |
| Disintegration | 10-60 seconds | 5-30 minutes (in GI tract) | 10–20 mins (GI tract) | Immediate (pre-dissolved) |
| Absorption Speed | Fast (potential buccal absorption) | Moderate | Moderate | Fastest |
| Patient Suitability | Ideal for dysphagia, children, elderly | Not suitable for dysphagia | May be opened (for some types) | Best for pediatrics |
| Taste Masking | Must be well-flavored | Coating masks taste | Shell masks taste | Easily flavored |
| Dosing Precision | Precise | Precise | High | Variable (measuring needed) |
| Stability | =Moisture-sensitive (needs special packaging) |
| Humidity-sensitive | Short shelf life (often refrigerated) |
| Examples |
Zofran ODT, Maxalt MLT | Tylenol tablets | Advil capsules | Children's Tylenol liquid |
Table no 2: Difference between MDS, Tablet, Capsule, liquids
Limitations of Mouth Dissolving Tablet:
• Mechanical strength: Mouth-dissolving tablets often have compromised mechanical strength.
• Hygroscopicity: Many mouth-dissolving tablets are hygroscopic, requiring special packaging to maintain their integrity.
• Brittleness and friability: These tablets are typically brittle and prone to damage due to their porous nature and low compression force (20).
• Packaging challenges: Specialized packaging, such as peel-off blister packs, may be necessary to protect the tablets.
• Formulation challenges: Developing mouth-dissolving tablets for potent or odor-unpleasant medications can be difficult, requiring careful consideration during formulation (21).
Problems with Existing Oral Dosage form:
• Patients with tremors may struggle with liquids and powders due to difficulty swallowing.
• Dysphagia can cause solid dosage forms like tablets and capsules to adhere to the esophagus, potentially leading to ulcers, and is particularly problematic for elderly patients and young children (22).
• Liquid medications in multidose containers can lead to inconsistent dosing.
• Some patients may experience irritation from buccal or sublingual formulations, making them unappealing (23).
• Parenteral formulations, while effective, are often the most expensive and uncomfortable option, making cost a significant factor (24).
Technologies for Mouth Dissolving Tablets:
Conventional Technologies:
• Freeze Drying: Lyophilization, or freeze-drying, is a process that removes water from a product by freezing and then reducing the surrounding pressure to allow the frozen water to sublimate (change directly from a solid to a gas) without going through the liquid phase (25). This technique is particularly useful for preserving heat-sensitive pharmaceuticals and biological materials. The resulting product is highly porous, with a large surface area, which enables rapid dissolution, improved absorption, and enhanced bioavailability (26) .
• Tablet Molding: The solvent method and the heat method are the two types of molding processes. In order to create a wetted mass (compression molding), the powder blend is moistened with a hydro-alcoholic solvent and then compressed at low pressures in molded plates(27). The solvent is eliminated below by air-drying (27). The resulting tablets are small and light. The porous structure of the compressed tablets speeds up dissolution. A suspension containing a drug, agar, or sugar (such as lactose or mannitol) is made before the heat molding process begins (28).
• Direct Compression: Direct compression is a straightforward and cost-effective method for producing mouth-dispersing tablets (29). The drug mixture and excipients are compressed without prior treatment, often incorporating super disintegrants to enhance disintegration and dissolution rates. Optimizing disintegrant concentration is crucial, as it inversely affects disintegration time up to a critical concentration point (30). Beyond this point, further increases in disintegrant concentration do not significantly impact disintegration time. However, hygroscopicity can be a limitation (31). Alternatively, sugar-based excipients like fructose, dextrose, and others (such as xylitol, mannitol, and sorbitol) can be used, offering pleasant mouthfeel and high aqueous solubility(32).
Figure 1: Process of drying compression technology
• Spray Drying: Spray-drying is used to create mouth-dissolving tablets by formulating a mixture containing a bulking agent like mannitol, a disintegrant such as sodium starch glycolate or croscarmellose, and a matrix-supporting agent like gelatin (33). Adding an acid (e.g., citric acid) and an alkali (e.g., sodium bicarbonate) enhances disintegration and dissolution. The mixture is then spray-dried to produce a porous powder, which is compressed into tablets that disintegrate rapidly (in under 20 seconds) in aqueous media. (34).
Figure 2: Process Spray drying technology
• Sublimation: The sublimation technique for fast-dissolving tablets involves incorporating a volatile substance into the formulation, which is then removed through sublimation, creating pores that facilitate rapid disintegration in saliva. Substances like camphor, naphthalene, and urea can be used to create porous tablets with good mechanical strength. By removing the volatile component, the resulting tablets exhibit improved dissolution properties. This technique allows for the creation of tablets with tailored porosity and mechanical strength, enhancing their fast-dissolving characteristics. (37).
Figure 3: Steps involved in sublimation technology
Patented Technologies:
• Zydis Technologies: Zydis technology, developed by R P Scherer (Cardinal Health), involves freeze-drying a drug in a water-soluble matrix, typically gelatin. This process creates a light, fragile, and highly porous tablet that dissolves rapidly upon contact with saliva. The low water content in the final product inhibits microbial growth, providing self-preservation. Ideal candidates for Zydis formulation are drugs with fine particles, stable aqueous suspensions, and relatively low water solubility. The high limit for drug loading for water-soluble medications is extremely low (about 60 mg). Water-soluble drugs' primary issue is the creation of a eutectic mixture, which lowers the freezing point and produces glossy solids when frozen, causing the supporting structure to collapse during sublimation. Using a solvent mixture of water-soluble polyethylene glycol and methanol, the active blend was softened. Then, the softened mass was expelled through a syringe or extruder to divide a cylinder of the product into uniform segments using a heated blade to create tablets. Additionally, granules of bitter-tasting medications can be coated with the dried cylinder to cover their bitter flavor(40).
• Orasolv Technologies: The first fast-dissolving formulation developed in the CIMA lab. To reduce oral disintegration and dissolution time, tablets are made by direct compression with a lower compression force. One example of a slightly effervescent tablet that dissolves quickly in the mouth is Orasolv technology (41).Because of the action of effervescent agents, the active medications are taste-masked and dispersed in saliva. It gives the patient a pleasing feeling in their mouth. Orasolv technology's primary drawback is its lower mechanical strength. The manufactured tablets must be packed in a specially made pack because they are soft and brittle(42).
• Durasolv Technologies: Durasolv, a second-generation fast-dissolving tablet technology from CIMA, boasts enhanced mechanical strength due to its high compaction tableting process. This results in efficient and cost-effective production(43). However, the high compaction pressure may limit its suitability for formulations with high active ingredient doses. Durasolv is currently utilized in products such as Zorlip and Nulev, showcasing its potential in fast-dissolving tablet applications (44).
• Wowtab Technologies: The Wowtab technology, developed by Yamanouchi, enables the creation of intrabuccal soluble tablets that dissolve quickly without water. This technology combines granules with varying moldability properties - high and low - to achieve a balance between tablet hardness and rapid dissolution. By blending active ingredients with low-moldability saccharides and granulating with high-moldability saccharides, tablets can be compressed to meet specific requirements. The unique combination of properties allows for efficient tablet formulation(46).
Mouth dissolving tablets (MDTs) represent a significant advancement in drug delivery, offering numerous benefits such as rapid disintegration, improved patient compliance, and enhanced convenience. Their ability to dissolve quickly in the mouth without water makes them particularly useful for children, elderly patients, and individuals with swallowing difficulties. MDTs are successfully employed in various therapeutic fields, including pain relief, allergy treatment, and mental health, providing an effective alternative to traditional tablets and capsules. While they may come with slight drawbacks such as formulation complexity or higher costs, their advantages often outweigh these limitations. Overall, MDTs are a highly recommended dosage form for patients seeking ease of use and faster drug absorption. As technology progresses, further innovations in MDTs are expected to enhance their efficacy and accessibility, solidifying their role in modern medicine.
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My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
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Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
