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Review Article | DOI: https://doi.org/10.31579/2690-8808/292
Laboratory of Combinatorial Drug Discovery Department of Applied Chemistry, National Yang Ming Chiao Tung University Hsinchu, Taiwan 300-10, Taiwan.
*Corresponding Author: Suman Thummanagoti, Laboratory of Combinatorial Drug Discovery Department of Applied Chemistry, National Yang Ming Chiao Tung University Hsinchu, Taiwan 300-10, Taiwan.
Citation: Suman Thummanagoti, (2026), Microwave-Assisted Convergent Synthesis of Pyrrolo, Pyrido, Isoindolo Bisbenzimidazolones on Ionic Liquid Support, J, Clinical Case Reports and Studies, 7(1); DOI:10.31579/2690-8808/292
Copyright: ©, 2026, Suman Thummanagoti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 22 December 2025 | Accepted: 29 December 2025 | Published: 02 January 2026
Keywords: dentistry; techniques; computer
The assessment, comprehensively reviewed the challenges of gas flaring in Nigeria, including the exploration, formation and extraction of crude oil. Gas flaring is simply the open-air combustion of fuel gas. Initial start-up flaring, Continuous production flaring and Operational/Non-continuous production flaring which are the 3 major classified categories of flaring were discussed, including composition of flared gases, types of flare gases such as ground flares, pit flares and elevated flares. The cumulative effects of gas flaring under the headings: Environments, Health, Economy and other effects were thoroughly discussed. Flaring has many disastrous consequences such as; decrease in the life expectancy of people living near flare sites due to poisonous emissions which lead to a variety of health challenges and diseases. Flaring also contributes to global warming, which is a major concern today as it causes extreme weather conditions, extinction of certain species and climate change. Nigeria stands to gain a great deal from utilizing natural gas properly in terms of revenue and increased job opportunities, consequently it is necessary that the flaring of natural gas should be stopped. Several alternatives have been proposed, including using flared gas to produce electricity and as a petrochemical feedstock, liquefying of flare gas and reinjecting it into the earth as a secondary oil recovery technique. Nigeria has made several policies to reduce and subsequently end gas flaring and has set multiple deadlines which ended up being postponed severally. The new deadline to end gas flaring in Nigeria is now anticipated to be by 2030. However, due to many setbacks, it is possible that the deadline may yet be shifted again.
In this paper we have been explored rapid and efficient synthesis to generate structurally complex bisheterocyclic libraries on soluble Ionic liquid support by the use of focused microwave irradiation. The bis-heterocyclic compounds, characterized by the presence of two heterocyclic cores connected by a single bond space, provided structurally linear heterogeneous libraries with skeletal diversity. The ionic liquid immobilized benzimidazole-1,2- diamine 5 has been used as a scaffold to generate structurally diverse analogues. The IL immobilized benzimidazole-1,2-diamine with various aliphatic and aromatic γ and δ -ketoacids using catalytic amount of trifluroacetic acid under focused microwave irradiation led to formation of diverse heterocyclic molecules have been described. The pyrrolo[1,2-a]bisbenziimidazol-1-one, isoindolo[1,2-a]bisbenzimidazole-1-one and pirido[1,2-a]bisbenziimidazol-1-one which are accessible in good yield from IL conjugate diamine in a single-step procedure, undergo a tandem reaction involving intermolecular electrocyclizations. The assembly of both heterocyclic rings was constructed on ionic liquid in a convergent combinatorial fashion. The relative high yield and purities with three points of diversity has been reported.
Highly functionalized various ring size bis-heterocycles, with different hetero atoms and substitution patterns are of major interest in the Pharmaceutical and agricultural industry due to the many intrinsic biological properties of these substances1. Thus the composition of bis-heterocyclic comprises pyrido[1,2-a] benzimidazole derivatives are ligands for the BZD site on GABA-A receptors and are thus useful for the treatment of disorders of the central nervous system including convulsion such as epileptic seizures, anxiety, depression, muscular spams, sleep disorders, attention deficit hyperactivity disorder2. Polycyclic bis-heterocycles containing imidazopyridine and imidazopyrimidine or Imidazo-[2,1-a]isoindole moiety constitute basic structural frameworks of various derivatives have been found potent against respiratory syncytical virus infection which is a leading cause of lower respiratory tract infection3. The concern Oxazolo-[2,3-a]isoindole and imidazo[2,1-a]isoindole derivatives shown antiviral medicaments4. Benzimidazoles in combination with the Pyrrolo[2, 1-a] isoidol-5-ones are shown to be an inhibitory activity on the Hsp90 chaperon protein to exhibit anticancer activity, and more particularly via the inhibition of the ATPase-type catalytic activity of the Hsp90 chaperone protein5. The geometric assembly of bisheterocycles characterized by the benzimidazole as a core connected by a spacer of variable length/structure, provided structural relevant compounds are apparently currents drugs6. However, interest remain strong for new approaches to produce complex hybrid molecules warrant further consideration as a means to identify complex structures with novel biological activities.
Owing, to the numerous problems associated with the solid phase synthesis7 such as low specific load and heterogeneous reaction phase, soluble polymer supported synthesis proved to be a useful alternative8. However, problems of high viscosity of the medium and the purification of the products and recycling of soluble polymers offered disadvantages over the Ionic liquid supported synthesis9. Ionic liquid substituted combinatorial synthesis has become a very effective method used for the production of combinatorial libraries with the high degree generation of chemical diversity10. The use suitable functionalized ionic liquids have made it possible to develop a multitude of methodologies for synthesis on ionic liquid supported synthesis11. The numerous advantageous associated with the ionic liquid supported syntheses as easy purification by simple washing, the possibility of using various techniques such as parallel synthesis making it possible to simultaneously produce a large quantity of products12. The nature of high thermal stability, their low volatilities and their very low vapor pressure, their low inflammability, their strong solubilization power of the salts as well as of the neutral organic molecules and polymers and finally the possibility of easy recycling has been strongly appealing the green media supported synthesis of small molecule libraries13. Despite advantages of ionic liquid supported synthesis to produce chemical library synthesis, applications of convergent, diversity-oriented synthesis to prepare libraries of natural-product-like molecules are underdeveloped. Synthetic organic chemistry has much impacted by the introduction of precision controlled microwave reactors14. The numerous reactions such has heterocycle formation, metal catalyzed cross-coupling, cycloaddition, condensation reactions have been explored under microwave irradiation15. The advantage of Microwave heating reduces the reaction times in comparison with traditional heating. In addition, the yields of the reactions are often increased and the time for optimizing the reaction conditions is minimized in comparison to conventional heating methods16. Due to the ionic conduction Ionic liquids absorbs microwave irradiation extremely well and transfers energy rapidly17. According to the present incarnation found that ionic liquid supported synthesis allows an easy automation together with microwave assisted heating, gives rise to unexpected advantages such as high yields of the compounds with high purity and possibility to eliminate time-consuming conventional heating methods, which are necessary when producing library of compounds. Furthermore, the reaction times in the homogeneous system substantially shortened as compared to other methods of heating.
Scheme 1: Library Scaffolds and Related Biologically Active Molecules
Despite the broad range of biological activities that was associated with the combination of benzimidazole with the pyrido[1,2-a]benzimidazole, pyrido[1,2-a]benzimidazole and imidazo[2,1-a]isoindole very few reports have been reported for the successful construction of aforementioned three classes of bis heterocycles in a linear fashion. Herein, we describe an efficient approach by the combination of ionic liquid supported synthesis
under microwave irradiation in order to gain rapid access of the aforementioned three classes of heterocycles with the three points of structural diversity in a linear single bond space bisheterocycles. The strategic accommodation of bisheterocycles and the versatility of the synthetic route have introduced the greater molecular diversity building blocks in good purity and high yields were reported.
Scheme 2: Microwave-Assisted multistep synthesis of Pyrrolo[1, 2-a]bis-benzimidazol-1-one, Pyrido[1, 2-a]bis-benzimidazol-1-one.
The synthesis has begun by choosing the 3-hydroxyethyl-(1-methylimidazolium)-tetrafluoroborate 1 as ionic liquid matrix for the preparation of the desired chemical library. Synthesis of the 3-hydroxyethyl-(1-methylimidazolium)-tetrafluoroborate was performed by the reported literature by taking the 1-methylimidazole and 2-bromoethanol18. In order to generate the benzimidazole based building block with one diversity point 4-fluoro-3-nitrobenzoicacid 2 has chosen the starting material to carry out the steps ahead on ionic liquid support. The 3-hydroxyethyl-(1-methylimidazolium)-tetrafluoroborate having the terminal hydroxyl group coupled molecules has been used to serve the Ionic liquid support for the growing chain. The esterification of Ionic liquid teriminal hydroxyl group with the 4-fluoro-3-nitrobenzoicacid was carried out in the presence of DCC and the catalytic amount of DMAP in acetonitrile and dichloromethane as a co-solvent for about 20 minutes in the microwave irradiaton to offered IL conjugate 3. Whereas the same reaction under room temperature reaction formation of esterbond took place two days reaction time. By taking the distinct solubility features of the ionic liquids, purification has been carried out by precipitation of Ionic liquid conjugate in the low polar organic solvents such as ether. Ionic liquid conjugate substrate further treated with the various primary amines in order to displace the fluorine atom in the nucleophilic substitution manner. This reaction has done in the presence of microwave irradiation for about 10 min of reaction time to offered ionic liquid supported conjugate 4. While the same preceding reaction has taken 5 hr. of reflux condition reaction time. Further IL conjugate 4 has treated with Zinc and ammonium formate for about 20 minutes at the room temperature to furnish IL conjugate diamine 5. In the course of planning and executing the synthesis of 14 and 17 analogues a built-in structural diverse Ortho-diamino ester 5 as an initiator for our present strategy. By taking an Ortho-diamino ester 5 coupled with 4-fluoro-3-nitrobenzoic acid to get the anilide conjugates 6 where there is an ample opportunity to generate second diversity through nucleophilic substitution by various primary amines. This reaction was performed under microwave irradiation at 100oC, 8 bar for about 10 min in the presence of DCC and catalytic amount of DMAP in dichloromethane under sealed vessel. Whereas to carry out this reaction under conventional heating methods 20 h of reflux or 50 min of domestic microwave heating. In order to generate mono ring imidazole with one point of diversity we have been used anilide conjugate 6 to intromolecular ring cyclization through the nucleophilic addition of secondary amines to the amide carbonyl carbon. This reaction was performed under microwave irradiation in the presence of catalytic amount of Trifluoro acetic acid and anhydrous Megnesiumsulfate at 100oC for about 5 min in ethlenedichloride to convert into benzimidazole 7.
Imidazole formation was impressive yield by using 10% trifluoroacetic acid in ethelenedichloride, which generates the electrophilicity on amide carbonyl carbon than usual and in the presence of anhydrous megnesiumsulfate in order to avoid moisture contamination which decreases the product efficiency along with the high boiling point solvent led good yield. After completion of the reaction the ionic liquid supported conjugate was precipitated and washed with cold ether. The ortho nitro fluoro groups in imidazole 7 have been used to ipso-fluro displacement via SN Ar by various aliphatic and aromatic primary amines to generate second diversity. This reaction was performed under microwave irradiation at 100oC for about 5 min to give 8.
The obtained ionic liquid bound O-nitro anilines 8 were used to perform reduction to convert nitro to amine group by using excess amount of Zn and Ammoniumformate in methanol. This reaction was completed within 30 min without starting any material left yield to get conjugate diamine 9. The completion of the reaction has been confirmed by the color change of the reaction mixture from dark brown to colorless. This has been used as a scaffold to generate third diversity oriented heterocyclic molecules by various γ and δ aliphatic and aromatic ketoacids. This reaction was performed in ethlenedichloride by taking conjugatediamine and ketoacids in the presence of catalytic amount of Trifluoroacetic acid and a dehydrating agent such as anhydrous Megnesiumsulfate or 4 Ao Molecular sieves in a sealed vessel under microwave irradiation at 130oC for about 10 min offered 12, 17. The formation of the products with the Il conjugate diamine by using various ketoacids such as β-ketoacids and γ-ketoacids with variation of substituents led to the five and six membered terminal pyrrolo, pyrido cycles on the bisbenzimidazole has proceeds well on the same reaction time intervals. This library of analogues has extended by taking the aromatic ketoacids under above mentioned reaction conditions proceeds well without leaving any undesirable products or unreacted starting material. Whereas the same reaction with 5% trifluoroacetic acid in ethlenedichloride under the same reaction conditions by applying the microwave irradiation under various ketoacids the formation of linear symmetrical keto tethered bis benzimidazoles 11, 18 have been observed. The products have been confirmed after the detachment of the support. The variation of TFA amount led to the various bisheterocycles under the short period of reaction times with impressive yields is an synergistic effect. These products have been observed in both the aromatic and aliphatic ketoacids in the same intervals upon microwave irradiation on the ionic liquid support. The ionic liquid conjugated products 12, 17 further treated with the lawesson’s reagent in the presence of ethlenedichloride for about 1500C of reaction temperature to 15 min to offered 13, 19 of thioamide analogues. Although, these types of reaction carried out in the literature using anhydrous toluene heated to reflux for 24 h with a Dean-Stark apparatus gained moderate yields. Furthermore, it involves tedious process and time consuming to generate large number of compounds19. Therefore, here we reported facile and an efficient process with high yield and purities with the association of two heterocycles in one molecule. The formation of the reaction products 12 have been observed by the naked eye. After the completion of the microwave irradiation we have been found that under the far Ultra-Violet light exposure these compounds are showed to be fluorescent in the presence of ionic liquid conjugate. Whereas the other group of isoindolo[1,2-a]bis benzimidazoles were cannot observed fluorescence up on far UV light exposure. Considering the mechanistic aspects of the formation of these products, It would be understood that the primary amine of conjugate diamine attack to the γ and δ keto carbonyl center which is most electrophilic centre induced by the trifluoroacetic acid there by formation of an imine to generate transient intermediate by the removal of 1 equiv. of water to offered the imine intermediate. The lone pair electrons on the secondary nitrogen attack to the preferred conformation B imine below the Ar-C=N- coplane, followed by elimination of another equivalent of water to form the products. Eventually cleavage of the soluble ionic liquid support was accomplished by using NaOMe in methanol under microwave conditions for about 120oC of reaction temperature to obtain Ionic liquid free 14, 20 desired analogues in good to excellent yields. We have been found that purity from 71-93% after detaching the each and every product from the support. The characteristic peaks for all these compounds have been found that enantiomeric methyl group which was identified by the 1H NMR spectroscopy by the range of 1.45-1.80 ppm as a singlet and the quaternary carbon identified through the 13C by the range of 84-90 ppm. By the IR absorbance in the range of 1700-1720 cm-1 has confirmed the presence of tertiary amide carbonyl.
In Summary, we have been successfully developed rapid and efficient synthesis of pyrrolo[1,2-a]bisbenzimidazole, pirido[1,2-a]bisbenzimidazole and isoindole[1,2-a]bisbenzimidazoles and their thioamide derivatives on soluble ionic liquid support by using the focused microwave energy under acid catalyzed conditions affording three class of bisheterocyclic products. The reaction progression was monitored by the conventional spectroscopic methods like 1H, 13C NMR and Mass spectroscopy. The intramolecular condensation of β, γ-Ketoacids with ionic liquid bound conjugate diamine has been optimized for library production. It is noteworthy to mention that at all the stages we have been found that substrate containing ionic liquid was stable although in the harsh microwave conditions. By the use of optimized microwave reaction conditions from hours to min and with the ease of simple purification resulting drug like substances with high purities have been achieved.
General Procedure for the Synthesis of Ionic Liquid conjugated Diamine 5.
Ionic Liquid 1 (0.5 g, 0.2 mmol) in acetonitrile (5 mL) was added to the solution of 4-fluro-3-nitrobenzoic acid 2 (0.51 g, 2.7 mmol, 1.2 equiv) in dichloromethane/acetonitrile (5 mL) in the presence of N,N’–dicyclohexylcarbodiimide (0.57 g, 2.7 mmol, 1.2 equiv) as coupling reagent and a catalytic amount of N,N’-dimethylamino pyridine (DMAP, 0.002 g) under microwave irradiation at 80 oC for about 20 minutes to afford the ester 3. The precipitated dicyclohexyl urea (DCU) was filtered through a fritted Celite plug. The Celite plug was rinsed with acetinitrile and the combined organic phase was concentrated under vacuum. The crude reaction mixtures were precipitated by slow addition of excess of cold ether (100 mL). The precipitated ester conjugate was then filtered through a fritted funnel and washed several times to remove the byproducts and dried. To a solution of 3 in acetonitrile (5 mL), various primary amines (6.7 mmol, 3.0 equiv) in (5 mL) dichloromethane was added and the reaction mixtures were irradiated in microwave cavity at 80 oC for 10 min to afford the Ionic-liquid immobilized nitroamines 4. Upon concentration under reduced pressure, the crude residue was precipitated by addition of excess of cold ether (100 mL). The precipitated IL conjugate was then filtered through a fritted funnel and washed several times to remove the byproducts and dried. The subsequent reduction of nitro group proceeded by using Zn (7.0 equiv) and NH4COOH (15.0 equiv) in methanol at room temperature for about 15 minutes under vigorous stirring. The insoluble Zn was removed by filtration and the mixture was dried under vacuum. The obtained residue was dissolve in dichloromethane and washed with 2M HCI (10 mLx3). The organic phase was dried over MgSO4 and concentrated to afford ionic liquid supported dimaine 5.
General Synthetic Procedure for the Preparation of the ionic liquid Bound3-(4-Fluoro-3-nitrobenzamido)-4 (substituted amino) Carboxylates 6.
Ionic liquid bound o-phenylene diamine 5 (0.5 g, 0.25 mmol, 1.0 equiv) has been taken into the microwave vessel in 5ml of dichloromethane to this a solution of 4-fluoro-3-nitrobenzoic acid (0.11 g, 0.60 mmol, 1.2 equiv) in dichloromethane/acetonitrile (5 ml) was added in the presence of N,N′-dicyclo- hexylcarbodiimide (DCC) (0.144 g, 0.70 mmol, 1.2 equiv) and N,N′- dimethylamino pyridine (DMAP) (3 mg). The reaction mixture was allowed to stir at room temperature for few minutes and subsequently irradiated microwave for 10 min to obtain the ionic liquid bound amide conjugates 6. After completion of the reaction, the insoluble dicyclohexylurea (DCU) was filtered. The obtained filtrate was concentrated and precipitated by slow addition of cold ether, the amide conjugate 6 was filtered through fritted funnel. The crude product was washed successively with ether to remove the impurities and dried for further steps.
General Synthetic Procedure for the Preparation of ionic liquid Bound Benzimidazole 7:
To a solution of 6 in 1,2-dichloroethane has been taken into microwave vessel for this trifluoroacetic acid (0.4 mL) and MgSO4 (0.5 g) were added and irradiated under microwave conditions for about 5 min. After completion of the reaction, the reaction mixture allowed to room temperature, MgSO4 was removed through celite. The reaction mixture were precipitated by slow addition of excess of cold ether (150 mL) and filtered through a fritted funnel to give the compound 7, and dried for further steps.
General synthetic procedure for the preparation of the ionic liquid immobilized diamine 9.
The resulting conjugate 7 was taken into the microwave vessel to treated with various amines (2.31 mmol, 7.0 equiv) in dichloromethane (5 mL) under microwave irradiation for about 5 min. After the completion of the reaction, reaction mixture was subjected to the rotavapor. The resultant crude was precipitated by the slow addition of cold ether to get the ionic liquid conjugate 8. The conjugate 8 was dissolved in appropriate amount of methanol added zinc (3.3 mmol, 30.0 equiv) and ammonium formate (3.75 mmol, 15.0 equiv) allowed stirring at room temperature for about 30 minutes. The reduced nitrogroup was confirmed by the colure change of the reaction mixture from yellow to colorless. Zinc was removed by centrifugation and filtration, and dichloromethane was added to precipitate ammoniumformate. After filtration through Celite, ionic liquid-immobilized diamine 9 was obtained.
General Synthetic procedure for the preparation of Pyrrolo[1,2-a]bisbenziimidazole and isoindolo [1,2-a]bisbenzimidazl-1-one 12, 17.
To a solution of conjugate diamine 9 in 5 mL of ethylenedichloride has been placed in microwave vessel. To this catalytic amount Trifluotoaceticacid and a dehydrating agent such as anhydrous Megnesiumsulphate (0.5 g) or 4 Ao MS (0.5 g) along with various aliphatic and aromatic γ, δ- ketoacids or ketoesters (1.2 equiv) were added. The reaction mixture was allowed to stir for a while at room temperature subsequently subjected to microwave irradiation for about 10 min at 130oC, 10 bar pressure. After the completion of the reaction, the reaction mixture was filtered through the celite in order to remove dehydrating agents. The residue was precipitated by the slow addition of cold ether, and dried to obtain 12, 17.
General Synthetic procedure for the preparation of Pyrrolo[1,2-a]bisbenziimidazole and isoindolo [1,2-a]bisbenzimidazl-1-one thioamides 13, 19.
To the solution of ionic liquid conjugates 12, 17 ethlenedicholoride (10 ml), was added by the Lowesson’s reagent (0.7 equiv) and subjected to MW irradiation for about 10 min at 150 oC, to offered 13&17 derivatives. The solvent evacuated crude residue has been precipitated by the addition of excess cold ether (100 mL). The precipitation of IL conjugate filtered through the fritted funnel, fritted funnel was rinsed acetonitrile and thereby evaporated the solvent to offered 13, 19 derivatives.
General Procedure for the Cleavage of ionic liquid bound Polycylic Derivatives 14, 15.
To a solution of conjugates 12, 17 in methanol (10 mL), NaOMe (0.1 g) was added and allowed to microwave irradiation for about 120oC, 15 min. The reaction mixture was monitored by TLC, after completion of the reaction, the reaction mixture was extracted by the slow addition of cold ether (120 mL) and the ionic liquid was filtered off and subjected to the rotavapor. The residue was dried under vacuum and the crude was analyzed by the HPLC with UV detection at λ= 254 nm (column Sphereclone 5µ Si (250×4.6 mm); gradient 50% ethyl acetate in hexane; flow rate 1 mL/min.). The obtained solid was then purified by neutral silica gel column chromatography and eluted with a mixture of ethylacetate and hexane (1:1) to get the title compounds 14 or 15 in good yield.
This work was financially supported by the National Science Council (NSC) of Taiwan and also the authorities of the National Chiao Tung University, for providing laboratory facilities.
Supporting Information Available.
The detailed experimental procedure for the synthesis of compounds; spectral characteristics of the synthesized compounds; 1H NMR, 13C NMR spectra of final compounds were available.
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Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
