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Review Article | DOI: https://doi.org/10.31579/2693-4779/297
Associate Professor in Noble Homoeopathic college and Research Institute, Junagadh, India.
*Corresponding Author: Anurag Verma, Associate Professor in Noble Homoeopathic college and Research Institute, Junagadh, India.
Citation: Anurag Verma, (2025), Efficacy of Equisetum Hyemale 3C in Nocturnal Enuresis in Children Below 15 years, Clinical Research and Clinical Trials, 13(4); DOI:10.31579/2693-4779/297
Copyright: © 2025, Anurag Verma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 09 September 2025 | Accepted: 25 September 2025 | Published: 07 October 2025
Keywords: nocturnal enuresis; homoeopathic treatment; equisetum hyemale 3c potency; efficacy
Homoeopathy is said to be effective in many diseases and the data and philosophy of homoeopathy give great value to the drug treatment in cases of nocturnal enuresis.
The term enuresis means "to void urine". Nocturnal enuresis, also called bedwetting, is involuntary urination while asleep after the age at which bladder control usually begins. Bedwetting in children can result in emotional stress. At least 90% of enuretic children have primary nocturnal enuresis i.c., they wet only at night during sleep and have never had a sustained period of dryness. Diurnal enuresis (daytime wetting) is much less common, as is secondary enuresis which develops after a child has had a sustained period of bladder control. More than 85% of children attain complete diurnal and nocturnal control of bladder by 6 years of age. The remaining 15% gain continence at approximately 15% per year, such that by adolescence only 0.5%-1% children have enuresis. Primary nocturnal enuresis is common. The incidence is three times higher in boys than in girls. Most children with enuresis become continent by adolescence or earlier. The family history in such cases frequently reveals other members, especially fathers, who have had prolonged nighttime bedwetting problems. Although the cause of primary nocturnal enuresis is not established, it appears to be related to maturational delay of sleep and arousal mechanisms or to delay in development of increased bladder capacity. Etiologically, it is generally viewed as a developmental disorder or maturational lag that children will outgrow. The most common complication of enuresis is low self-esteem in response to criticism from caregivers and embarrassment if peers are aware of the problem. Older children with enuresis may be reluctant to attend sleep-overs and be self-conscious with peers. The first line of treatment is usually non-pharmacological, comprising motivational therapy and use of alarm devices. Pharmacotherapy is to be done if enuresis persists despite the institution of alarm and regular voiding habits. Imipramine, Desmopresin acetate is the preferred contemporary medication for treating children with enuresis in modern medicine. However, the common side effects include headache, nausea, upset stomach or stomach pain, diarrhea or flushing of the face (warmth, redness and tingly feeling) but in homoeopathy there is enough scope for treating nocturnal enuresis. Night time continence is a normal developmental process which a child attains as early as up to 6 years of age. Therefore, no treatment is required to be started before the age of 6 years. Daytime bladder control & coordination occurs by 4 years. As of now, genetic inheritance is known to be a strong factor along with family history of diabetes mellitus, renal diseases in both parents where spontaneous resolution either comes very late in life or even ended with therapy for diabetes mellitus type II. It is largely asymptomatic. Therefore, is a potential cause of not yielding to any therapeutic measure along with homoeopathy. In Homoeopathic parlance it can be classified as a "One sided disease" (Aphorism 173 stated- "The only diseases that seem to have but few symptoms belong chiefly to the class of chronic diseases). There are various other causes involved in Bed-wetting including emotional set back like- abandoned, fear psychosis in children etc.
Hypothesis for present Work:
Null Hypothesis: Improvement in cases of nocturnal enuresis with homoeopathic medicine Equisetum hyemale 3C potency is because of sampling variation and may be because of psychotherapy. The result is not statistically significant. Alternative Hypothesis: Improvement in cases of nocturnal enuresis with homoeopathic medicine Equisetum hyemale 3C potency is medicinal. The result is statistically significant. Research Question arising out of Hypothesis
1. What is the role of psychotherapy in children with nocturnal enuresis?
2. To investigate the effect of Equisetum hyemale in 3C potency in relieving & lessening down the frequency of enuresis.
Out come
At the end of study, I had seen that Equisetum hyemale 3C can effectively be proved as a standalone specific remedy in Nocturnal Enuresis.
Types Of Enuresis
1. Primary enuresis: When the symptom has always existed and the child has not been dried for a period longer than 6 months.
2. Secondary enuresis: When there has been a symptom-free interval of 6 months or years and then begins to wet the bed.
Aetiology
Psychological: >95%, Organic: UTI, Constipation, Polyuria, e.g., IDDM, Diabetes insipidus, poly-uric renal failure, Neurological, e.g. spina bifida, Renal structural abnormality, e. g. ectopic ureter. The etiology of nocturnal enuresis is not fully understood, although there are three common causes which are excessive urine volume, poor sleep arousal and bladder contractions. Bedwetting has a strong genetic component. Children whose parents were not enuretic have only a 15% incidence of bedwetting. When one or both parents were bedwetters, the rate jumps to 449% and 77% respectively. These first two items are the most common factors in bedwetting, but current medical technology offers no easy testing for either cause. There is no test to prove that bedwetting is only a developmental delay, and genetic testing offers little or no benefit. As a result, other conditions should be ruled out. The following causes are less common, but are easier to prove and more clearly treated. In some bedwetting children an increase in ADH production does not occur, while other children may produce an increased amount of ADH but their response is insufficient. Attention deficit hyperactivity syndrome (ADHD) children with ADHD are 2.7 times more likely to have bedwetting issues. Caffeine (caffeine increases urine production).
Reduced bladder capacity: Children with nocturnal enuresis often have a small bladder capacity compared to their peers. When these children sleep at night, their bladders are less able to hold all of their urine until morning.
Constipation
Chronic constipation can cause bedwetting. When the bowels are full, it can put a pressure on the bladder. Infection/disease Infections and disease are more strongly connected with secondary nocturnal enuresis and with daytime bedwetting. Less than 59% of all bedwetting cases are caused by infection or disease, the most common of which is a urinary tract infection.) More severe neurological-developmental issues patients with intellectual disabilities have a higher rate of bedwetting problems. One study of seven-year-olds showed that "handicapped and intellectually disabled children had a bedwetting rate almost three times higher than "non-handicapped children" (26.69% Vs 9.5% respectively), Psychological issues (e.g., death in the family, sexual abuse, extreme bullying) are established as a cause of secondary nocturnal enuresis, but arc very rarely a cause of primary nocturnal enuresis type bedwetting. Bedwetting can also be a symptom of a pediatric neuropsychological disorder called PANDAs l (Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections).
Sleep apnea
Sleep apnea stemming from an upper airway obstruction has been associated with bedwetting. Snoring and enlarged tonsils or adenoids are a sign of potential sleep apnea problems. ls)
Sleepwalking
Sleepwalking can lead to bedwetting. During sleepwalking, a sleepwalker may think he/she is in another room. When the sleepwalker urinates during a sleepwalking episode, he/she usually thinks that they are in the bathroom, and therefore urinates where they think the toilet should be. Cases of this have included opening a closet and urinating in it: urinating on the sofa and simply urinating in the middle of the room. Stress is a cause of people who return to wetting the bed. Researchers find that moving to a new town. parent conflict or divorce, arrival of a new baby, or loss of a loved one or pet can cause insecurity, contributing to returning bedwetting.
Type 1 diabetes mellitus
Nocturnal enuresis could be the presenting symptom of type I diabetes mellitus, classically associated with polyuria. polydipsia, and polyphagia: weight loss, lethargy and diaper candidiasis may also be present in those with new-onset disease.
Unconfirmed
Food allergies
Food allergies may be part of the cause in some patients. This is not well established, requiring further research,
Improper toilet training
This is another disputed cause of bedwetting. This theory was more widely supported in the last century and is still cited by some authors today. Some say bedwetting can be caused by improper toilet training, ol either by starting the problem when the child is too young or by being too forceful. Recent research has shown more mixed results and a connection to toilet training
has not been proven or disproven. According to American Academy of Pediatrics, more child abuse occurs during potty training than in any other developmental stage.
Dandelions
Dandelions are reputed to be a potent diuretic.
Aetiology of enuresis has been widely debated but is still not completely understood. Some of the common causes are listed below:
Primary enuresis:
-Delay in maturation of the relevant part of nervous system.
- Acquired control of bladder late.
-Organic causes
- Defect in urethral valve, adherent or elongated prepuce, phymosis in the boys.
- Ectopic ureter which may open in urethral part of vagina, hooded clitoris in girls.
-Over enthusiasm on the part of parents for toilet training leads to undue anxiety and enuresis.
- Scolding child for enuresis has negative impact on child. Secondary enuresis:
- Worry at home/school, birth of sibling, excitement like watching horror stories at nightime.
-Constipation, bladder calculi. urinary tract infection.
- Diabetes mellitus/ diabetes insipidus.
- Neurogenic bladder
- Erythema, eczema, pruritus
Dietary use of much sugar, too much coffee
- Worm infestation Traumatic
- After circumcision operation
-Catheterization
One of the most important things to keep in mind about urination is that the process is not under voluntary control. The individual parts and nerves of urinary system must work in unison for successful urination to occur. As the bladder muscles contract, the urinary sphincter relaxes, allowing urine to flow into the urethra and exit the body. The communication between the nerve and muscle groups that link the bladder and the brain is very complicated and explains the diferent ages at which children become dry. The following timetable shows the development of bladder control
- Ages birth-18 months: the child is unaware ofbladder filling or emptying.
- Ages 18-24 months: the child has conscious sensation ofbladder emptying.
- Ages 2-3 years: most children develop the ability to voluntarily stop urination and develop appropriate toileting skills.
-Ages 3-5 years: Most children have achieved urinary control and are dry both day and night.
Management
Behavioral modification: It may help the children to stay dry at night. These modifications are as follows -
Restricting fluids: Limiting a child's fluid intake after dinner is designed to reduce his urine production at night.
Nighttime waking: One of the techniques parents use to help children stay dry is to take them to the bathroom a few hours after they go to sleep.
Bladder therapy: This approach encourages children to increase their fluid intake during the day, to think about the sensation of a full bladder, to respond to their bladder at the first signal, and to fully empty their bladder each time they have to go.
Bedwetting alarm: Available in a variety of models, all alarms work on the premise of waking the child if the wetness sensor detects urine.
Psychotherapy: A treatment option for children with secondary enuresis due to a change or traumatic event in their life or for those experiencing a significant problem with self-esteem because of their bedwetting.
Before discussing the treatment of nocturnal enuresis, there are two important things to keep in mind. First, children do not wet the bed on purpose. Second, most pediatricians do not consider bedwetting to be a problem until a child is at least 6 years of age.
Simple behavioral methods are recommended as initial treatment. Enuretic alarm therapy and medications may be more effective but have potential side effects.
- Motivational therapy in nocturnal enuresis mainly involves parent and child education. Guilt should be allayed by providing facts.
- Bedwetting alarms: Physicians also frequently suggest bedwetting alarms which sound loud when they sense moisture. This can help condition the child to wake at the sensation of a full bladder. This is an effective method.
Statistical analysis:
Chi square test is performed to test the statistical significance of efficacy of homeopathic potency 3C over constitutional in nocturnal enuresis.
So, this test was performed to assess the statistical significance of Homoeopathic treatment to the patients suffering from nocturnal enuresis.
• Null Hypothesis (Ho): There is no difference in improvement rates of Experimental Group and Control Group.
. Alternative Hypothesis (H1): There is remarkable difference in improvement rates between Experimental Group and Control Group at 0.05 level of significance.
The 2X2 contingency table for assessment of the obtained results is shown below.
| Treatment | Cured | Not cured | Total |
| Experimental Cases | O= 33 | O= 2 | 35 (RT) |
| E=29.75 | E=5.25 | ||
| Control cases | O= 1 E= 4.25 | O= 4 E=0.75 | 5 (RT) |
| Total | 34(CT) | 6(CT) | GT =40 |
Table 1: Contingency table for assessment of results of this study, using Chi-Square test.
Total number of observations = 40 E (Expected Value) = RT X CT/GT O-Observed Value
E-ExpectedValue RT= Row Total
CT=Column Total GT= Grand Total χ2 = ∑(O-E)² /E
=∑ (33-29.75)²/29.75+(2-5.25)²/5.25+(1-4.25)²/4.25+(4-0.75)²/0.75
= 18.9356
DF (Degreeof Freedom) = (R-1) (C-1) DF - (2-1) (2-1)
DF=1
For degree of freedomof 1, the tabulated value of Chi-Square at P-0.05 is 3.84. Calculated value in the above case is 18.935 So, tcal > ttab.
So, P<<0>
ALTERNATING HYPOTHESIS (H1): Improvement in cases of nocturnal enuresis with homoeopathic medicineEquisetum hyemale 3C potency is medicinal effect.The result is statistically significant.
The present study comprises the nocturnal enuresis and its Homoeopathic treatment. The study comprises randomly selected patients of a particular age group of different sex, religion and socioeconomic condition (n=40). The study was an observational, prospective, single blind, medicine-controlled study. First of all, a thorough case taking was done following the standard case-taking Proforma supplied by the Noble Homoeopathic Medical College & Research Institute. Proper analysis and evaluation of each case were searched out and repertorized by using the homoeopathic software Synthesis. Among the medicines that came out from the repertorization the final
selection was done after consulting homeopathic materia medica. Medicines were given in 3C potency by considering the case and the dose and repetition were maintained as far as practicable with the homoeopathic principle. The cases were followedat a regular interval of time of 7 days. It is of utmost importance to take every case properly to understand and interpret the symptoms of patients and to apply the knowledge of the study in the practical field and in clinical practice of homoeopathy. The present study comprises 40 cases of nocturnal enuresis, who attended the OPD of Noble Homoeopathic MedicalCollege & ResearchInstitute, Junagadh. While selecting the similimum the importance was given to totality of symptoms. The age distribution was shown in this study, the majority of cases were observed in the age group 06-10 years. The incidence of nocturnal enuresis in males (30 cases) is found slightly higher than females (10 cases). The numberof patients studiedin this experiment were only 40. Thecriteria for selection of 3C potency and repetition of doses in homoeopathy are not beyond question. Statistical test was carried out to find out the effectiveness of homocopathic treatmentof the patient suffering from nocturnal enuresis. Of the total 40 cases in which Equisetum hyemale 3C potency was prescribed in 35 cases, where 33 cases showed improvement and 02 cases showed no improvement under homoeopathic treatment. Whereas 5 cases were prescribed constitutional medicines, where 04 cases showed no improvement. Repertorial analysis is used as a guidingpath to find out the correct medicineand consultation with materia medica also needed for the selection of correct homoeopathic medicine.In the study of 40 cases it was seen that after thorough and proper case-taking of all the cases included for the study emergedsufficient amounts of characteristic generalas well as particular symptoms by which repertorization were easily done.
In this research an effort was made to show the efficacy of Homoeopathic potency 3C in the cases of nocturnal enuresis.Selected cases were between the age group of 07-15 years. The cases were diagnosed on the clinical presentations. 40 patients were taken for the study. 35 cases were in the experimental group and 5 cases were in the control group.All 35 cases of the experimental group were selected after careful analysis; Homoeopathic medicine in 3C potency was prescribed while constitutional medicineswere given to 5 cases of the control group. Follow up of the cases at a regularinterval of time of 7 days. Whilestudying nocturnal enuresisin detail I have noted that the drugshave been extensively proved again and again verifiedas regards to its clinical efficacy. Psychotherapy was given to all patients considering the social stigma attached to this disease. Psychotherapy played a key role in the management of the cases. The results obtained in the experimental group of patients who were prescribed Equisetum hyemale 3C potencywere encouraging. Almost 94% of patients showed improvement with the medicine. In this work the following inference was drawn.
1.Nocturnal enuresis is the deeper aspect of totality of symptoms which indicate correct similimum instead of the apparent pathology.
2.Homoeopathic treatment in 3C potency based on the totality of symptoms proved to be the best for the treatment.
3.Homoeopathic medicines in 3C potency are effective.
The study shows that the drug is effective in Nocturnal enuresis, but it is highly effective only when it is administered according to strict homoeopathic principles. Homoeopathy being a distinct mode of therapeutics offers both curative as well as palliative treatment with some limitations, On the contrary modern system of medicine only offers a palliative mode of treatment to the patients suffering from nocturnal enuresis. This research work enabled me to study the different aspectsof nocturnal enuresisin detail. In my observation most of the cases showed signs of improvement which are marked, moderate, and mild with the selection of similimum derived from the totality of symptoms. In this observational study I must say that Homoeopathy has a highly effective role in the cases of nocturnal enuresis and without any perceptible side effects.Thus, we can definitely improve the generalhealth of patients.So, the study showed that homoeopathy is a distinct mode of therapeutics that offers a curative treatment for nocturnal enuresis.
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Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
