Dietary Supplementation of Poultry Herbs® on Growth performance, Immune Response and Haemato-Biochemical Parameters of Hubbard Broiler Chicken

Research Article | DOI: https://doi.org/10.31579/2690-1919/571

Dietary Supplementation of Poultry Herbs® on Growth performance, Immune Response and Haemato-Biochemical Parameters of Hubbard Broiler Chicken

  • Eimoga A.A 1*
  • Mubarak Olalekan Badmus 2
  • Alagbe, J.O 3

1Founder, Poultry Herbs Enterprise, Nigeria and National Sales Technical Coordinator, Feed Avenue Limited.

2University of Greenwich, United Kingdom (Agriculture for Sustainable Development).

3Department of Animal Science, University of Abuja, Nigeria.

*Corresponding Author: Eimoga A.A, Founder, Poultry Herbs Enterprise, Nigeria and National Sales Technical Coordinator, Feed Avenue Limited.

Citation: Eimoga A.A, Mubarak Olalekan Badmus and Alagbe, J.O, (2025), Dietary supplementation of Poultry Herbs® on Growth performance, Immune response and Haemato-Biochemical Parameters of Hubbard Broiler Chicken, J Clinical Research and Reports, 21(3); DOI:10.31579/2690-1919/571

Copyright: © 2025, Eimoga A.A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 18 August 2025 | Accepted: 20 October 2025 | Published: 30 October 2025

Keywords: antimicrobials; broilers; growth; plants; performance; phyto-constituents

Abstract

A 42 days study was carried out to examine the effect of dietary supplementation of Poultry herbs® on growth performance, immune response and haemato-biochemical parameters of Hubbard broiler chicken. 600 1-day- old broiler chicks (Hubbard) of mixed sex were randomly distributed into 5 treatment groups and each treatment had 5 replicates (20 birds per replicate). Experimental diet meets the requirement provided by the Nutritional Research Council. Neomycin was supplemented at 10 g/kg diet for birds in group A while poultry herbs (PH) was supplemented at 5 g, 10 g, 15 g, 20 g and 25 g/kg diet for birds in group B, C, D, E and F respectively using a completely randomized design. Clean water was also offered ad libitum. Analysis of phyto-constituents in PH showed that terpenoids (1091 mg/g), phenol (1000.3 mg/g) and flavonoids (977.4 mg/g) are the most prominent compound followed by alkaloids (500.9 mg/g), tannins (411.6 mg/g), steroids (208.5 mg/g), saponins (100.6 mg/g) and glycosides (86.55 mg/g) respectively. Average daily weight, average daily feed consumption and feed conversion ratio improved in birds fed PH in group: B, C, D, E and F compared to group A (p˂0.05). Higher mortality was recorded among birds in group A (2.20 %) and lower in group B (1.00 %) while none was recorded in the other groups. Population of microbes in the ceacum, Escherichia coli, Staphyllococcus spp, Salmonella spp, Streptococcus spp, Pseudomonas spp, Proteus spp were higher among birds in group A compared to other groups fed with PH whereas Lactobacillus spp were higher among birds in group B, C, D, E and F than in group A (p˂0.05). Haematocrit, total erythrocytes, hemoglobin, total leucocytes, lymphocytes, total protein, glucose, cholesterol, immunoglobulin (A, G and M) values were influenced (p˂0.05) except for basophil count (p˃0.05). It was concluded that PH is rich in phyto-constituents that are non-toxic and could be supplemented up to 25 g/kg in the diet of broilers without their growth performance and health status. 

Introduction

PH an acronym for poultry herbs is a blend of different medicinal plants consisting of dried garlic, ginger, turmeric, neem seeds, papaya seeds and Capsicum annuum. These plants have been explored in traditional medicine for the treatment of various ailments such as, skin infections, gastrointestinal disorder, snake bite, eye problem, sexually transmitted disease, kidney and liver diseases amongst others (Shanmugapriya et al., 2012; Klavina et al., 2015). Medicinal plants are rich in phyto-constituents (flavonoids, phenols, terpenoids, saponins, alkaloids, tannins, steroids etc.) which confers them the ability to perform multiple pharmacological roles such as, anti-inflammatory, antifungal, antiviral, immune-stimulatory, anti-helminthic, anti-tumor, antioxidant, cytotoxic, antidiarrheal, antimicrobial, cardio-protective, gastro-protective, antibacterial, anti-diabetic and antiviral (Karthika and Paulsamy, 2014; Mamza et al., 2012; Nurdiani et al., 2012).   

The concentration of these phyto-constituents can be influenced by age of plant, specie, location and processing methods (Ojediran et al., 2024b; Alagbe, 2024). Furthermore, extracts from medicinal plants have been suggested to inhibit the activities of some pathogenic organisms such as, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Staphylococcus epidermidis, Klebsiella pneumonia, Salmonella spp and Candida albicans (Manilal et al., 2011; Davendran and Balasubramanian, 2011; Prabhu and Guruvayoorappan, 2012). Medicinal plants have also been reported to be toxic free, eco-friendly, effective and has no withdrawal period (Alagbe, 2024). 

Previous studies have revealed that supplementation of medicinal plants in the diet of birds have beneficial effects on the secretion of endogenous enzymes (Lewis et al., 2003; Muritala et al., 2022), palatability and absorption of digested nutrients (Adewale et al., 2021), growth, efficient protection against pathogenic organisms through its immune system (Musa et al., 2020; Shittu et al., 2023) and modulation of fatty acid in meat samples (Lee et al., 2003). Mazharul et al. (2024) reported that Moringa powder dietary supplementation at 0.4 % had positive influence on the growth performance of birds. Mitsch et al. (2004) also confirmed that supplementation of essential oil at 200 mg/kg diet influenced carcass characteristics of broiler chickens.

In view of the abundant potential in PH and the urgent need to address the increasing cases of antimicrobial resistance, this study was designed to investigate the influence of dietary supplementation of Poultry herbs on growth performance, immune response and heamato-biochemical indices of Hubbard broilers. 

Materials and methods

Experimental site and purchase of Poultry herbs

The Poultry section at Sumitra Research Institute, Gujarat India was used for the study (7°25' N and 5°19' E. The experiment was carried out in accordance to the research ethics and guidelines of Animal management department of the Institute with reference number (SDM/02025) and the duration of the research was 42 days.

Poultry herbs (PH) was purchased from a Veterinary store in Kurama Street, Gbagyi Villa, Kaduna State, Nigeria. 50 g of the sample was placed in an airtight polythene bag and sent to biochemistry laboratory at Sumitra Research Institute, Gujarat, India for further analysis. Concentrations of phyto-constituents in PH were assayed as previously described by Alagbe (2024). 

Management of birds, design and experimental diet

Healthy 600 1-day- old broiler chicks (Hubbard) of mixed sex were randomly distributed into 5 treatment groups and each treatment had 5 replicates (20 birds per replicate) and transferred to an already disinfected battery cage. Upon arrival, birds were unboxed and their average initial body weight was taken using a digital sensitive scale (Xenum model T608, China). Birds were fed starter diet (week one to three) and finisher (week four to six). Experimental diet meets the requirement provided by the Nutritional Research Council in 1994 as presented in Table 1. Neomycin was supplemented at 10 g/kg diet for birds in group A while poultry herbs (PH) was supplemented at 5 g, 10 g, 15 g, 20 g and 25 g/kg diet for birds in group B, C, D, E and F respectively. A completely randomized design was used for the experiment while birds had unrestricted access to clean water. Parameters determined includes, final live weight, total feed consumption and feed conversion ratio from day 1 to 42.

Evaluation of blood parameters

On the 42nd day of the experiment three birds were randomly selected per replicate for haematological and serum biochemical indices. Blood samples (4 mL each per bird) was collected from the wing vein into labeled sample bottles. Bottles for haematology contains anti-coagulant (EDTA) while those for serum parameters was without anticoagulant. Haematological parameters were determined using COF® automatic dual blood analyzer (Model DF09C, China) while serum samples were analyzed using Symtex biochemical analyzer (Model BBOX/667, China). Each kit was operated adhering strictly to their manufacturer instructions and recommendations. 

Intestinal microbial population and immune estimation

For intestinal microbial estimation, two birds were randomly selected per replicates. 5g of intestinal content was collected into a labeled sample bottle followed by the addition of few drops of 1% peptone reagent before it was taken to the laboratory for further analysis. Enumeration of intestinal microbes was done using Dulox® microbial analyzer (Model BN/009C/025, Korea). 

Immunoglobin A, G and M count was done on the last day of the experiment by randomly selecting three birds per replicate (from same birds used for blood analysis). Analysis was carried out using Gluex® Auto-Immunex (Model FV/009V/ER04, China). 

Data analysis

Data obtained were analyzed using General Linear Model procedures of Statistical Analysis System (SAS, version 9.1.3 of 2010). Differences in mean were computed using Duncan’s Multiple Range Test for multiple comparisons. Significance was determined at p < 0>

Experimental Results

ComponentsStarter (1-21d)Finisher (22-42d)
Corn50.0057.5
Soy bean meal (47.0 percent)35.7532.4
Fish meal (70.0 percent)7.203.00
Oyster shell4.004.00
Bone meal2.002.00
Lysine 0.250.25
Methionine0.250.25
Premix (0.25 %)0.250.25
Sodium chloride0.300.35
Total100.0100.0
   
Determined values (%)  
Crude protein (g/kg)234.5210.7
Crude fibre (g/kg)34.8837.90
Ether extract (g/kg)42.1638.57
Lysine (g/kg)12.1711.06
Methionine (g/kg)4.954.81
Methionine + Cysteine (g/kg)8.747.39
Energy (ME/Kcal/kg)2996.53170.9

Vitamin and Mineral premix Each 2.5 kg consists of: Vit A 18,000, 000 IU; Vit D3, 4000, 000 IU; Vit. E. 20g; Vit k3 6 g; Vit B1, 2500 mg ; Vit B2, 100g ; Vit B6, 300 g; Vit B12, 50 mg; Pantothenic acid, 100 g; Niacin, 85 g , Folic acid , 1900 mg ; Biotin, 100 g; Choline Chloride, 660 mg, Fe, 60 g; Mn, 120 g; Cu, 3.7 g; Co, 250 mg; Si, 180 mg and Zn , 96 g

Table 1: Nutrient composition of experimental diet (Starter and finisher mash)

ComponentsConcentrations (mg/g)
Terpenoids1091.2
Tannins411.6
Alkaloids500.9
Flavonoids977.4
Phenols1000.3
Saponins100.6
Glycosides86.55
Steroids 208.5

Table 2: Phyto-components in P-Herbs used for the experiment

ParametersABCDEFSEM
Starter phase (1 to 21 days)       
Experimental period (days)42.0042.0042.0042.0042.0042.00-
Initial body weight (g/bird)50.0950.0250.0149.9949.9749.860.01
Final body weight (g/bird)600.1c750.3b755.2b766.4b900.9a910.1a56.31
***Average daily weight gain (g/bird)28.57c35.72b35.96b36.49b42.90a43.33a20.78
Feed consumption (g/bird)1500.6c1744.8b1750.1b1751.6b1818.3a1822.9a110.2
Average daily feed consumption (g/bird)71.45c83.02b83.33b83.40b86.58a86.80a0.05
feed conversion ratio2.50a2.32b2.32b2.28bc2.01c2.00c0.001
Mortality (%)1.20a0.000.000.000.000.000.01
        
Finisher phase (22-42 days)       
Average body weight gain (g/bird)1154.1c1390.6b1394.7b1577.2a1580.8a1590.2a97.22
Average daily body weight gain (g/bird)54.95c66.21b66.41b75.10a75.27a75.72a0.06
Feed consumption (g/bird)3000.23001.33005.73110.53115.43118.2160.9
Average daily feed consumption (g/bird)142.8142.9143.1148.1148.3148.40.09
feed conversion ratio2.59a2.15b2.15b2.00c2.00c2.00c0.01
Mortality (%)1.00a1.00b0.000.000.000.000.01
        
Overall production (1-42 days)       
Total weight gain 1754.21c2140.9b2149.9b2343.6a2481.7a2500.3a100.3
*Average daily weight gain (g/bird)41.76c50.97bc54.18b55.80b59.08a59.53a0.03
Total feed consumption (g/bird)4500.8b4746.1a4755.8a4862.1a4933.7a4941.1a171.9
**Average daily feed consumption (g/bird)107.1b116.0a116.2a116.8a117.4a117.6a0.07
Feed conversion ratio 2.56a2.21b2.21b2.07bc2.00c2.00c0.02
Mortality (%)2.20a1.00b0.000.000.000.000.01

Values followed by different letters were significantly different (p˂0.05); Group A:  Experimental diet with Neomycin at 10 g/kg diet; Group B, C, D, E and F: Experimental diet supplemented with Poultry herbs (PH) at 5 g, 10g, 15 g, 20 g and 25 g/kg respectively. SEM: standard error of mean; *total weight gain/42 d; ** total feed consumption/42d; ***final body weight - initial body weight

Table 3: Impact of P-herbs supplementation on the growth performance of Hubbard broiler chickens

ComponentsABCDEFSEM
Hematocrit (%)28.66b29.41b33.89a33.97a33.91a34.05a6.21
Total erythrocytes (×1012/L)1.98c2.45b3.00a3.01a3.05a3.13a0.05
Haemoglobin (g/L)89.44c100.0b119.7a120.1a121.5a124.6a10.40
Total leucocytes (×109/L)16.73b   18.55b23.08a23.16a23.25a23.33a0.44
Basophils (%)1.431.481.751.781.881.940.02
Heterophils (%)31.95a30.51a26.90b26.94b25.88b25.80b4.91
Lymphocytes (%)60.52b69.04b75.08a75.11a76.02a76.09a7.06

Values followed by different letters were significantly different (p˂0.05); Group A:  Experimental diet with Neomycin at 10 g/kg diet; Group B, C, D, E and F: Experimental diet supplemented with Poultry herbs (PH) at 5 g, 10g, 15 g, 20 g and 25 g/kg respectively. SEM: standard error of mean

Table 3: Impact of dietary supplementation of P-herbs on the haematological parameters of Hubbard broilers

ComponentsABCDEFSEM
Total protein (g/dL)3.13c4.11b4.40a4.50a4.62a4.73a0.13
Albumin (g/dL)1.46c2.11b2.38b2.42a2.50a2.58a0.04
Globulin (g/dL)1.57c2.00b2.02b2.08b2.12a2.15a0.03
Glucose (mg/dL)128.6a112.3b110.9b95.61c92.30c91.47c9.55
Cholesterol (mg/dL)102.8a92.51b90.55b80.43c80.21c80.20c8.02

Values followed by different letters were significantly different (p˂0.05); Group A:  Experimental diet with Neomycin at 10 g/kg diet; Group B, C, D, E and F: Experimental diet supplemented with Poultry herbs (PH) at 5 g, 10g, 15 g, 20 g and 25 g/kg respectively. SEM: standard error of mean

Table 4: Impact of dietary supplementation of P-herbs on the serum biochemical parameters of Hubbard broilers

VariablesABCDEFSEM
IgA (mg/dL)1.79b2.30a2.37a2.46a2.80a2.95a0.03
IgG (mg/dL)0.88b1.62a1.71a1.73a1.80a1.85a0.02
IgM (mg/dL)0.93b1.76a1.81a1.82a1.87a1.96a0.02

Values followed by different letters were significantly different (p˂0.05); Group A:  Experimental diet with Neomycin at 10 g/kg diet; Group B, C, D, E and F: Experimental diet supplemented with Poultry herbs (PH) at 5 g, 10g, 15 g, 20 g and 25 g/kg respectively. SEM: standard error of mean

Table 5: Influence of P-herbs supplementation on the Immune parameters of Hubbard broilers

Variables (Log 10 CFU)ABCDEFSEM
Escherichia coli3.05a2.83b2.57b2.52b2.51b2.51b0.03
Staphyllococcus spp3.77a2.91b2.33b2.21b2.16b2.16b0.03
Streptococcus spp2.78a1.92b1.01b0.92b0.91b0.90b0.04
Lactobacillus spp3.63c4.61b5.06a5.11a5.16a5.29a0.12

Values followed by different letters were significantly different (p˂0.05); Group A:  Experimental diet with Neomycin at 10 g/kg diet; Group B, C, D, E and F: Experimental diet supplemented with Poultry herbs (PH) at 5 g, 10g, 15 g, 20 g and 25 g/kg respectively. SEM: standard error of mean

Table 6: Influence of P-herbs supplementation on the Intestinal microflora of Hubbard broilers

Phyto-components in P-Herbs used for the experiment revealed that terpenoids had the highest concentration of 1091.2 mg/g than phenol (1000.3 mg/g), flavonoids (977.4 mg/g), alkaloids (500.9 mg/g), tannins (411.6 mg/g), steroids (208.5 mg/g), saponins (100.6 mg/g) and glycosides (86.55 mg/g) as presented in Table 2. 

Impact of P-herbs supplementation on the growth performance of Hubbard broiler chickens is presented in Table 3. In the starter phase, average daily weight gain and average daily feed consumption follow similar trend, birds fed diet B (5 g PH per kg diet), C (10 g PH per kg diet) and D (15 g PH per kg) were similar (p˃0.05). Those which received diet E and F (20 g and 25 g PH per kg diet) were also similar (p˃0.05) but significantly higher than birds fed diet A (basal diet with 10 g Neomycin® per kg diet). Feed conversion ratio and percentage mortality values which varied from 2.00 - 2.50 and 1.00 - 1.20 % were significantly affected (p˂0.05) by the treatment. In the finisher phase, average daily weight gain (54.95 - 75.72 g/bird) were higher among birds which received diet D, E and F, intermediate in diet B and C, lowest in diet A (p˂0.05). Average daily feed consumption values (142.8 - 148.4 g/bird) were not influenced (p˂0.05). Conversely, feed conversion ratio was higher among birds which received diet A, intermediate in diet B and C, lowest among bird given diet D, E and F (p˂0.05). In the overall production cycle (1-42d), average daily weight gain values which varied from 41.76 to 59.53 g/bird were higher among birds in diet E (59.08 g) and F (59.93 g), intermediate in diet B (53.97 g), C (54.18 g), D (55.80 g) and lower in diet A (41.76 g) (p˂0.05). Average daily feed consumption were higher among birds fed diet supplemented with PH relative to those given diet A (p˂0.05). Feed conversion ratio decreases as the level of PH supplementation increased in the diet of birds (p˂0.05).

Impact of dietary supplementation of P-herbs on the haematological parameters of Hubbard broilers is presented in Table 3. Total erythrocytes values varied from 1.98 to 3.13 (×1012/L), haemoglobin (89.44 - 124.6 g/L), haematocrit (28.66 - 34.05 %), total leucocytes [(16.73 - 23.33 (×109/L)], heterophils (25.80 - 31.95 %) lymphocytes (60.52 - 76.09 %) were all influenced (p˂0.05) by the treatments except for basophils count (1.43 - 1.94 %) (p˃0.05). 

Impact of dietary supplementation of P-herbs on the serum biochemical parameters of Hubbard broilers is presented in Table 4. Total protein, albumin and globulin values among birds fed diet D, E was similar to F (p˃0.05) but significantly higher than those that received diet A and B (p˂0.05). Cholesterol and glucose values follows similar trend, as their concentrations were higher (p˂0.050 in among birds given diet A [(102.8 mg/dL; 128.6 mg/dL)] than in diet B [(92.51 mg/dL; 112.3 mg/dL)], C [(90.55 mg/dL; 110.9 mg/dL)]; D [(80.43 mg/dL; 95.61 mg/dL)], E [(80.21 mg/dL; 92.30 mg/dL)] and E [(80.20 mg/dL; 91.47 mg/dL)] respectively.

Influence of P-herbs supplementation on the Immune parameters of Hubbard broilers (Table 5). Immunoglobulin A, G and M concentrations were lower (p˂0.05) among birds that received diet A [(1.79; 0.88; 0.93 (mg/dL)] than diet B [2.30; 1.62; 1.76 (mg/dL)], C [(2.37; 1.71; 1.81 (mg/dL)], D [(2.46; 1.73; 1.82 (mg/dL)], E [(2.80; 1.80; 1.87 (mg/dL)] and diet F [(2.95; 1.85; 1.96 (mg/dL)] in that order.

Influence of P-herbs supplementation on the Intestinal microflora of Hubbard broilers is presented in Table 6. Intestinal count of Escherichia coli, Staphyllococcus spp and Streptococcus spp were higher (p˂0.05) among birds fed diet A [(3.05; 3.77; 2.78 (Log 10 CFU)] than B [(2.83; 2.91; 1.92 (Log 10 CFU)], C [(2.57; 2.33; 1.01 (Log 10 CFU)], diet D [(2.52; 2.21; 0.92 (Log 10 CFU)], E[(2.51; 2.16; 0.91 (Log 10 CFU)] and F  [(2.51; 2.16; 0.90 (Log 10 CFU)]. Conversely, Lactobacillus spp count were higher (p˂0.05) among birds that received diet F [(5.29 (Log 10 CFU)], E [(5.16 (Log 10 CFU)], D [(5.11 (Log 10 CFU)], C [(5.06 (Log 10 CFU)], B [(4.61 (Log 10 CFU)] and A [(3.63 (Log 10 CFU)]. 

Discussion

Phytochemicals or phyto-constituents are natural non-toxic, ecofriendly and effective compounds with abundant medicinal and pharmacological properties such as anti-inflammatory, anti-cancer, anti-helminthic, immune-modulatory, anti-malarial, cytotoxic, antidiarrheal, antioxidant, anti-tumor, antifungal, antimicrobial, anti-hypertensive, antibacterial, cardio-protective amongst others (Ojediran et al., 2024b; Singh et al., 2022). Phyto-constituents are also regarded as the power house of medicinal plants (Alagbe, 2025). The most prominent compounds (terpenoids, phenols and flavonoids) in poultry herbs (PH) observed in this study indicates that it has antimicrobial, anti-inflammatory, immuno-stimulatory and antibacterial activities (Ojediran et al., 2024a; Oluwafemi et al., 2021). They also have the capacity to prevent the activities of free radicals and prevents pathogens from attaching itself to the intestinal walls of birds, thus preventing infections (Musa et al., 2020). The synergy of these compounds with tannins, alkaloids, saponins, glycosides and steroids ensures a healthy gut and strong immune system to maintain good health and performance among birds (Omokore and Alagbe, 2019). Results on the overall performance revealed that as the level of dietary supplementation of PH increased across the group led to a significant improvement in average daily weight gain of birds. Though birds diet D (15 g PH per kg), diet E and F (20 g and 25 g PH per kg diet) had a higher body weight gain compared to those which received diet A and B while birds given diet A had the lowest weight gain. This suggests that supplementation of PH encourages birds endogenous enzyme secretion thus resulting in improved nutrient digestibility and growth (Oluwafemi et al., 2021; Agubosi et al., 2021). The activities these phyto-constituents also produce a gastro-protective and hepato-protective results in birds (Alagbe, 2024). This outcome is in consonance with the reports of (John, 2024b) when phytogenics was supplemented in the diet of broiler chickens. Similarly, average daily feed consumption was higher among birds fed with PH compared to those which received solely antibiotics (group A). This result suggests that the supplementation of PH in the diet makes it more palatable. Feed palatability is a combination of flavour, taste, and mouth feel, as well as physiological responses following digestion that determine feed consumption (Ruben, 2023; John, 2024c). Result obtained is in agreement with the reports of Daniel et al. (2023) when pawpaw essential oil is supplemented in the diet of broilers. PH have also shown to possess strong antimicrobial affinity for undesirable pathogens in the gut of birds compared to those given antibiotics (Aliyu et al., 2024). It is important to note that PH does not deposit toxic substances in animal products or cause multi-drug resistance (John, 2024a). Alagbe (2025) reported that supplementation of medicinal plants in the diet of birds have inhibited pathogens like Escherichia coli, Staphyllococcus spp, Salmonella spp, Streptococcus spp, Pseudomonas spp, Proteus spp amongst others in the gut thereby reducing inflammation and prevents them from attachment to the intestinal wall (Omokore and Alagbe, 2019; John, 2024e). They also allow the proliferation of beneficial bacteria like Lactobacillus spp, thus providing a balanced intestinal flora (Musa et al., 2020; Adewale et al., 2021). This is similar to the mode of action of PH recorded in this experiment. By supplementing PH in the diet of birds creates a positive impact in the gut and also mitigate against health challenges.

The presence of phyto-constituents in PH can also boost immune defense by promoting or stimulating birds’ antibody production to neutralize free radicals and reducing oxidative stress in the gut (Alagbe et al., 2025; Shittu et al., 2024). This result suggests that PH possess antioxidant properties possibly due to the presence of terpenoids, flavonoids and phenolic compound (Singh et al., 2022). Result obtained in this study agrees with the reports of Muritala et al. (2022) when Polyalthia longifolia leaf extracts was given to broiler chickens in the place of conventional antibiotics. 

The haematocrit, haemoglobin and total erythrocyte values were within the normal ranges (25.00  to  35.00  %), (70.00  to  130.00 g/L) and (1.50 to  3.50 x 1012/ L) reported by Abdi-Hachesoo et al. (2011) and Kalita et al. (2018). Higher levels haematocrit, haemoglobin and total erythrocyte reported especially among birds that received PH suggests an improvement in oxygen-carrying capacity of the cells, thus resulting in sufficient nutrients in the tissue of birds (John, 2024d; Ladokun et al., 2008). The result obtained in this study also suggests the absence of bone marrow disorder and vitamin deficiency especially folate in the blood (Alagbe et al., 2022; Islam et al., 2004). Total leucocytes, heterophils, basophils and lymphocytes were within the normal baseline ranges 10.00 - 25.00 (×109/L), 20.00 - 40.00 %, 1.00 - 2.50 % and 45.00 - 85.00 % reported by Talebi et al. (2005); Dalai et al. (2015). Total leucocytes and their differentials (basophils, heterophils and lymphocytes) are involved in the protection of the body against infections (Campbell, 2012). 

Impact of dietary supplementation of P-herbs on the serum biochemical parameters of Hubbard broilers revealed that total protein, albumin and globulin values were within the range of 3.00 - 5.50 g/dL, 1.85 - 2.92 g/dL and 1.50 - 2.50 g/dL reported by Simaraks et al. (2004). Abdi-Hachesoo et al. (2013) also confirmed that total protein values for broilers varied from 2.60 - 6.50 g/dL. The result obtained indicates the absence of hepatic dysfunction and also a sign that the birds were well nourished (Keçeci and Çöl, 2011). The birds fed PH had values of cholesterol which were lower than the normal range (100.0 −150.0 mg/dL) reported by Campbell (2012). However, the values were within the normal range (110 to 250 mg/dL) as cited by Keçeci and Çöl, 2011). Result obtained suggests that supplementation of PH in the diet could lower serum cholesterol, thus performing cardio-protective properties (Café et al., 2012; Wati et al., 2015). Concentrations of glucose in this experiment 91.47 - 128.6 mg/dL was lower than the baseline values of 190 - 510 mg/dl cited by Thrall (2007). Elevation in glucose concentrations can be as a result environmental stress or poor animal management (Adewale et al., 2021).

Conclusion

Result obtained suggests that PH had positive effect on the growth performance of birds especially when supplemented up to 20 g/kg diet. PH are toxic free and can hinder the activities of Escherichia coli, Staphyllococcus spp, Salmonella spp, Streptococcus spp, Pseudomonas spp, Proteus spp and increase the proliferation of Lactobacillus spp thus creating a balanced gut. Blood parameters examined were within the established range for birds suggesting that broilers were healthy.

References

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Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

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Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

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Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

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Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

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Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

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Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

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Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

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Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

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Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

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Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

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Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

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Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

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Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

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Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

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Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

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Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

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Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

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Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

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Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

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Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

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S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

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Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

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George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe

Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed

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Mahmoud Kamal Moustafa Ahmed

Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.

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Dr Elena Salvatore

Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal

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Christoph Maurer

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.

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Baciulescu Laura

Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.

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Dr Mamoun Magzoub