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Review Article | DOI: https://doi.org/10.31579/2766-2314/175
1Grodno State Medical University, Grodno, Belarus.
*Corresponding Author: Elizaveta I Bon, Candidate of biological science, Assistant professor of pathophysiology department named D. A. Maslakov, Grodno State Medical University; Grodno State Medical University, 80 Gorky St,230009, Grodno, Belarus
Citation: Bon E.I., Maksimovich N.Ye., Shiraza A.L, Junaid A.L, Sham F.S (2025), Review Article: Microbiome and Human Health., J, Biotechnology and Bioprocessing, 6(6): DOI: 10.31579/2766-2314/175
Copyright: © 2025 E. I. Bon, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 01 December 2025 | Accepted: 08 December 2025 | Published: 16 December 2025
Keywords: microbiome; physical health; mental health
The human microbiome, a complex community of microorganisms residing within and on our bodies, has emerged as a critical player in shaping both physical and mental well-being. This article explores the profound influence of the microbiome on various aspects of human health. We delve into the impact of microbial communities inhabiting the gut, esophagus, oral cavity, respiratory tract, skin, and reproductive system, highlighting their roles in maintaining physiological functions and preventing disease. Furthermore, we examine the emerging evidence linking the microbiome to mental health disorders, including depression, bipolar disorder, anxiety, and stress-related conditions. By elucidating the intricate connections between the microbiome and human health, this review underscores the potential for novel therapeutic strategies targeting the microbiome to promote overall wellness.
The Gut Microbiome and Physical Health
All these body's parts studied such as the esophagus, lungs, skin surface, oral cavity, and intestine have a biome in them that deals with microorganisms. The majority of its components are bacteria, with the remainder being viruses, phages, fungus, and archaea. The rest of the saying is traced by fungi and archaea, and triangles have also triumphed. It is understandable why they are frequently called fungi. In controlled infections and in many environmental microbial settings, bacteria tend to settle down at particular spots referred to as biofilms, whether or not they happen to be part of the microbial community. Their favorable traits to exist in a microbiome are trust to community dwelling and communication.
In order to form a community, bacteria utilize tiny particles referred to as auto inducers to interact and communicate with each other. One of the ways they ascertaining the amount of intra species communication and the presence of interspecies communication is through a process termed as quorum seeing [1]. The communication enables a number of species to synergistically create an enclosed microbiome and sustain the community. Even though all territories contain microbiomes, this review intends to emphasize on the relationship between mortal complaint pathology and the bacterial community forming the microbiome.
Among the most well-known human microbiomes, the intestinal tract, or gut, has been the subject of the most research. The host's digestion and nutrition depend on the gut microbiota, which can produce nutrients from substrates like xyloglucans, which are present in lettuce and onions but that host processes cannot reach. Compared to other areas of the body, the gut microbiome contains a greater variety of bacterial species.
Based on information gathered by the MetaHIT metagenomic analysis database and the Mortal Microbiome Project, about 3000 bacterial species have been isolated from mortal faeces. More than 90 percent of the gut microbiome is made up of Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes, which are divided into 11 distinct phyla [2,3]. Be aware that niche-specificity frequently determines the makeup of a microbiome in a larger host environment. The tonsils, throat, epoxies, slaver, tongue, buccal mucosa, palate, subgingival and supragingival shrine, and tooth shells are among the niche-specific microbiomes found in the general area of the oral depression, despite the frequent reference to the "oral microbiome" [4].
The 16S rRNA gene reference sequences for oral species in the several colourful habitats mentioned above are carefully curated and linked to accessible genomes in the mortal Oral Microbiome Database (eHOMD) [5]. Of the 775 microbial species in the database as of the end of 2021, 30 had not yet been clothed and 57 had formal names. These are inferred using 2074 oral and nasal genomes, which correspond to 529 taxa currently included in the database. The greatest number of rubrics are found in the phyla Firmicutes and Proteobacteria, which are followed by Actinobacteria and Bacteroidetes. The healthy human lower respiratory tract is not sterile, unlike what some people initially believed, and instead has microbial populations that are similar to but different from those of the upper respiratory tract [6,7].
Numerous distinct functional taxonomic units (OTUs), some culturable and named and others not, have been identified thanks to the use of 16S rRNA and whole-genome sequencing. Rather than the varying rates of reduplication of its members, the appearance of new species, which is typically caused by aspiration of largely concentrated oral concealment, and the junking of species, which is primarily caused by mucociliary concurrence, determine the size of the healthy lung microbiome, providing for a balanced rate in microbial composition [6,8]. Although research on the microbiota in lung diseases such pneumonia, chronic obstructive pulmonary disease (COPD), and cystic fibrosis is widespread, less is known about the microbiota in healthy lungs.
The primary bacterial species were skin commensals from the rubrics Staphylococcus, Streptococcus, Veillonella, Prevotella, and Propionibacterium, according to early work by Charlson et al. using 16S rDNA sequencing of bronchiolar lavage (BAL) samples from the lower respiratory tract. However, species from soil and water-associated rubrics like Burkholderia and Comamonada were also present [9], indicating that key characteristics of the lung microbiome were species accession from the host's nasopharynx, skin, and external terrain. This study also demonstrated that the phyla within the healthy lung microbiome Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, and OTUs belonging to the Prevotella, Veillonella, and Streptococcus rubrics.
Questions over slice ways and implicit bronchoscope impurity of samples led Dickson et al. to take over a rigorous experimental study minimizing impurity and gain a topographic figure of lower respiratory tract microbiota [10]. Results were harmonious with former studies showing that airway and lung bacterial communities act those of the oropharyngeal tract, with little substantiation of point-specific enrichment by reproducing bacteria.
Microbiomes in complaint countries
Complaint countries can affect from compositional changes in microbiome speciation or cornucopia changes within microbiome species, both performing in microbiome dysbiosis, or expression of acridity characteristics by a species within the microbiome.
Regarding the third of these, research indicates that under some conditions, asymptomatic microbiome species may exhibit acridity traits indicative of disease. With colonization rates of up to 36, Streptococcus agalactiae is typically regarded as a component of the normal vaginal microbiota. During gestation, still, the foetal transmission of S. agalactiae can be fatal to the invigorated and is a leading cause of morbidity and mortality in babies [11]. The exact medium that results in this switch to a malign phenotype is unknown; still, acridity is determined by the capsular serotype and acridity factors similar as the polysaccharide capsule, decoded by the cps gene, protein C, which includes the Ca face proteins (bca gene), Rib (caricature gene) and Cb (bac gene) [12]. Then, we examine a number of complaint states performing from conditioning within niche-specific microbiomes.
Although Streptococcus and Prevotella species make up the majority of the adult esophageal microbiome, alterations in age and complaint state similar to adenocarcinoma have been demonstrated to impact enrichment with Gram-negatives such as Haemophilus, Veillonella, and Rothnia spp., especially in the early stages of adenocarcinoma development [13].
Previous studies had also suggested that the esophageal microbiome in cases with influx esophagitis has high attention of Gram-negative species and that these are likely contributing to thepre-cancerous stage of adenocarcinoma development [14].
Lopetuso et al. have also examined changes in microbiome composition in Barratt's esophagus, another esophageal complaint state, and compared it to adenocarcinoma. Results from six Barratt's esophagus and ten adenocarcinoma samples showed a shift from the normal dominant Gram-positive Streptococci to Gram-negatives like Prevotella, Actinobacillus, and Veillonella, although this change was not as pronounced as that observed in the adenocarcinoma samples [15].
According to the study's recommendations, the esophageal microbiome's shift to Gram-negative bacteria becomes more noticeable as complaints become more rigid. A number of esophageal disorders include eosinophilic esophagitis, which is characterized by intraepithelial eosinophils in the scaled epithelium, dysregulated transubstantiating growth factor beta (TGF-b) product, and imperfect desmosomes. Mast cells and the cytokines IL-5 and IL-13 work together to cause the complaint state.
Eosinophils are triggered by overexpressing antimicrobial products like scrap cationic proteins, defensins, and DNA-containing extracellular traps, which may change the microbiome's makeup while also immortalizing the conditions needed to sustain the complaint [16,17]. Diets are one of the established treatments for eosinophilic esophagitis, which is also impacted by food allergies and nutrition. Researchers are now looking into links between the development of eosinophilic esophagitis and changes in the microbiome because of the microbiome's suggested role in this issue.
Harris et al.'s study of microbiome composition and eosinophilic esophagitis in 70 children [7 times their age] and adults with a history of esophageal narrowing, gelatin intolerance, and conditions leading to endoscopic complications indicating eosinophilic esophagitis [17] focused on a significant increase in Haemophilus sp. in undressed subjects compared to subjects without eosinophilic esophagitis. It included whole-genome sequencing and 16SrRNA. Benitez et al. compared cases of eosinophilic esophagitis before and after beneficial changes to a cohort of patients with non-eosinophilic esophagitis and found that although the overall bacterial cargo was significantly higher in eosinophilic esophagitis, the species diversity was not significantly lower than in the control group [18]. Eosinophilic esophagitis and changes in microbiome diversity in the adult population do not appear to be related, according to a recent study by Johnson et al. [19].
The gastrointestinal tract's (gut) microbiome has been the subject of the most research. Studies on the development of the child's gut microbiota and changes in the gut microbiome in various geographical countries over the past 20 years have shown disorders such as diabetes, liver disease, cancer, and, more recently, neurodegenerative diseases. In the case of infants, research has indicated that the manner of delivery (natural or caesarean), the kind of child feeding [bone or formula], the infant's gravid age at birth, hospitalization, and antibiotic use all have an impact on the microbiome development process [20]. The oxidized environment of the initial sterile gut is conducive to the colonization of facultative aerobes, among which Lactobacillus, Prevotella, and Sneathia sp. are among the most prevalent. Anaerobes follow them when oxygen is used up and the environment is more depleted [20].
The formation of a healthy gut microbiome depends on the presence of Bacteroides and Bifidobacterium, which are known to play a significant role in the susceptible response [21].
A study by Backhed et al. showed that within 5 days of vaginal delivery, a different population comprising substantially motherly gut bacteria similar as Escherichia, Bifidobacterium, Enterococcus and Bacteroides was apparent, whereas babies delivered by caesarean section contained a larger proportion of motherly skin foliage at the same time point [22]. Seditious bowel complaint (IBD) a complaint group that includes Crohn’s complaint and ulcerative colitis eventually leads to gut microbiome dysbiosis and a reduction in species diversity. This leads to the proliferation of invasive and glutinous E. coli strains, as well as facultative anaerobes. The colon, where bacterial populations are largest, and the terminal ileum and rectum, where faecal material accumulates, are where these strains are most visible [23].
Additionally, as compared to the microbiome of people without IBD, the overall microbiome is changed in IBD cases. The host pattern recognition receptor nucleotide-binding oligomerisation sphere-containing protein 2 NOD2 mutations serve as an example and are a risk factor for Crohn's disease.
Both Gram-positive and Gram-negative bacteria's peptidoglycans are impacted by NOD2. Studies conducted on NOD2-knockout mice showed a decrease in cytokine expression and an increase in a specific mucosa-associated microbial dysbiosis with changed focus of gut mucosal microorganisms [24].
Other beast studies have shown that the transfer of proinflammatory bacteria or microbiota from diseased mice to healthy mice induces bowel inflammation, and origin-free mice aren't susceptible to ulcerative colitis [ 25]. There are some antithetical data on the significance of microbial changes in IBD, stemming from the mortal microbiome design [26]. 132 people including 27 without IBD were followed for 1 time and compared for faecal metagenomes, metatranscriptomes, metaproteomes, viromes, metabolomes, host exomes, epigenomes, transcriptomes and serological biographies in samples taken over this time.
Longitudinal data could be gathered by reclaiming cases from both the active and inactive complaint ages. These findings showed that there were no discernible differences in metagenomic species between people with IBD and those without; nevertheless, metabolite pools showed a lower degree of individuality in IBD, which corresponded to earlier compliances indicating a decrease in microbial diversity [27].
Obesity [28-31], inflammation [32-34], and insulin insensitivity [35] among grandfathers with type 2 diabetes [T2D] has been associated with changes to the gut microbiota, though there is still no comprehensive examination of the deleterious interplay between T2D and the host's microbiome changes. During obesity, the composition of the human microbiome shifts, with increased representation of members from the Firmicute phylum compared to Bacteroidetes [36,37].
As for non-Westerners, a Japanese investigation revealed that the likelihood of observing Firmicute to Bacteroidetes ratio elevation was also present in the obese subjects. The same study also reported that five species of Firmicutes were associated with obese subjects whereas five species of Bacteroidetes were associated with non-obese subjects [38]. Same modifications have been set up for T2D [39,40]. Changes to the composition of the gut microbiome can lead to increased intestinal permeability and consequently, systemic inflammation.
The chronic, low-grade inflammatory state that is characteristic of diabetes and its related disorders [41]. In the case of T2D, some species have been linked with its presence or absence. It has been noted that T2D patients have an altered microbiome containing larger amounts of the bacterium Faecalibacterium prausnitzii. Once again, the type 2 diabetic gut microbiome is deficient in the mucus colonizing species A. muciniphila, which during sugar starvation conditions can metabolize mucin for carbon and nitrogen [42]. Niche-specific colonization of oral depression has shown the link of specific bacteria to their specific niches. Some 25% of people are also S. aureus positive which is the most likely colonist of the nostrils along with the skin-commensals S. epidermidis, Corynebacterium sp. and S. aureus. S. aureus colonization in the nares increases the risk of contamination of food products with pathogenic S. aureus growing in the nasal cavity which in turn raises the risk of food poisoning [43]. Using 16S RNA sequencing, research on the microbiota of 12 adults revealed Actinobacteria, Propionibacteriaceae, and Corynebacteriaceae were the three dominant phyla present in the nose while Firmicutes and Proteobacteria were found in the mouth. There was a difference in microbiome composition between the nasal cavity and the mouth, oral cavity, or the oral depression. Staphylococceae were absent in the oral depression, while in Strepotococcaceae, the sink of Firmicute rubrics, was the foremost as its constituted [44].
The predominating type of bacteria composing the pharyngeal microbiome belongs to benign Streptococcus species, which might be expected to have some communicable complaints together with diphtheria, meningitis, pneumonia, and other more severe pathogens. As a mouth ailment, periodontitis or PDIS can severely damage the premaxilla and the upper jaw bone along with the epoxies if left untreated. It has roots in inflammation stemming from the collapse of the immune system along with the peculiar oral microbiome of the individual. Among the various other oral flora that is its subordinate, some periodontopathic species which includes Tannerella forsythia, Porphyromonas gingivalis and Treponema denticola are to blame for the onset of PDIS.
The changes in microbiota during treatment for a manageable form of PDIS included, but were not limited to, Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella spp., Tannerella forsythia, Dialister spp., Selenomonas spp., Catonella morbi, Eubacterium spp., Filifactor alocis, Parvimonas micra, Peptostreptococcus, Fusobacterium, Pseudoramibacter alactolyticus, and Streptococcus intermedius [45].
Pathogenic bacterial species of the microbiome can derive in slavers in sufficient numbers to adversely affect the host or other’s wellbeing. Acute post infectious glomerulonephritis, rheumatic fever, TB, scarlet fever, erysipelas, cellulitis, necrotizing fasciitis, septicemia, and toxic shock syndrome are severe ailments that Group A Streptococci, comparable to S. pyogenes, can cause [46]. Umeda et al. studied six species of periodontopathic bacteria in whole slaver and sub gingival shrine from 202 subjects and concluded that whole slaver, along with P. gingivalis, Prevotella intermedia, Prevotella nigrescens, and T. denticola, serves as a reservoir and transmission pathway to periodontal lesions [47,48].
Given that the microbiome of the healthy lower respiratory tract exists, it is feasible to imagine the introduction of pathogenic organisms into the lung environment.
The upper respiratory tract is the primary source of microorganisms that the lower respiratory tract receives from the environment. With the support of the local flora, the weak defense mechanism should be able to keep out invaders who are mature and in good individuality. This is demonstrated by the dysbiosis brought on by the absence of cross membrane ion control in cystic fibrosis, which results in altered lung mucus landscape and microbiota. Certain species of bacteria thrive in this environment, and in fact, microbial alterations have been noted since immaturity.
Frayman et al. established that microbial diversity was considerably lower in the BAL samples from CF kids than in the non-CF controls in a 16S rRNA sequencing study of BAL samples obtained from 21 CF babies and 10 non-CF babies at 1.8 and 5 months after delivery [49]. Additionally, total bacterial biomass was almost correlated with the location of inflammation, with Staphylococcus, Ralstonia, and Methylobacterium showing the highest increases in CF babies and Fusobacterium, Neisseria, and Escherichia/Shigella showing the highest increases in non-CF babies. The overall bacterial biomass in CF was considerably higher than in non-CF samples [p<0>
One theory holds that asthma and impaired, vulnerable system development result from immaturity-induced lack of exposure to a variety of environmental microorganisms [52]. Studies have examined the role of microbiota along the gut-lung axis in asthma, and as previously said for CF, a dysbiosis in the gut microbiome can cause a concomitant lung dysbiosis in asthmatics. Preschool-aged children's microbiota studies by Stiemsma et al. demonstrated evidence of gut bacterial dysbiosis, specifically a decrease in the Lachnospiraceae family in favor of Clostridium, which is implicitly linked to asthma [53].
A metagenomic investigation of gut bacterial sequencing data from 36 adults with asthma compared to 185 controls looked at changes in the gut microbiome of adult asthmatics [54].
Asthmatics have reduced levels of butyrate-producing bacteria, such as Coprococcus eutactus and F. prausnitzii.
Increases in the prevalence of Clostridium bolteae, Clostridium ramosum, Clostridium spiroforme, and Eggerthella lenta—the latter of which has also been connected to an increase in IBD—were directly associated to this.
Long-term airway inflammation, respiratory discomfort, and habitual tailwind restriction are the hallmarks of COPD. Like CF instances, COPD patients experience exacerbations as a result of seditious episodes. It has been shown that the microbial diversity pattern in foam and farther-distant samples varies in COPD. Therefore, a method that samples the distal bronchi and alveoli similarly to BAL fluid is the preferred method for assessing the lung microbiome.
An initial analysis of BAL samples from four COPD cases showed that the severe complaint cases had less diversity loss than the mild cases, but one of the three healthy test individuals had an equivalent decrease of diversity. However, it should be mentioned that the limited sample size further reduces the power of the findings [55]. Pragman et al.'s analysis of 32 BAL samples from moderate COPD, eight from severe COPD, and ten non-COPD controls revealed that the COPD samples had higher levels of members of the anaerobic Gram-negative phylum Fusobacteria. This increase was evident across all taxonomic situations, including the rubrics Leptotrichia and Fusobacterium, Prevotella, Haemophilus, Fusobacterium, Pseudomonas, Streptococcus, Veillonella, and Porphyromonas [56]. Shotgun metagenomics and 16S rRNA sequencing were utilized to show that the gut of COPD patients had a decrease in the relative abundance of Firmicutes and an over-representation of Proteobacteria, which include the majority of pathogenic species [57].
As demonstrated in the examples below, variations in the microbiome composition between healthy and unhealthy nations are a contributing factor to a number of skin disorders.
Fahl et al. observed a shift in bacterial counts in psoriasis cases when compared to healthy controls. They found that Proteobacteria sp. were present on the body's box at significantly advanced situations, while Streptococcus and Propionibacterium sp. were present in lesions compared to healthy skin spots [58]. Subsequent research connected two different microbial species groups that predominate in psoriasis cases: a Firmicute-Actinobacteria-associated group and a Proteobacteria-associated group [59].
Atopic dermatitis is characterized by notable changes in the variety and makeup of the microbial communities inside microbiomes. S. aureus is the primary species found in skin lesions caused by atopic dermatitis. Even yet, S. aureus does not frequently colonize the skin of those who do not have atopic dermatitis.
According to research, aureus colonization of the skin is necessary for the development of lesions. Kong et al. established that, in contrast to less than five healthy individuals, more than 90 cases of atopic dermatitis are resolved by S. aureus on both lesional and non-lesional skin. Similarly, S. aureus becomes the dominating species in the microbiome's makeup near the lesion site, indicating a loss of variety [60]. Additionally, there is a rise in number of anaerobic species such Clostridium and Serratia marcescens within these lesions [61]. Puberty is usually linked to acne, a skin condition where P. acnes is known to be present in the lesions. Although P. acnes makes up around 90% of the microbiota in the sebaceous gland microbiome of healthy individuals, it does not cause acne. Only specific strains of lesion strains with genes likely responsible for their acridity are linked to acne, according to 16S rRNA sequencing, whereas other strains are linked to the healthy skin microbiome [62-65].
The Gut Microbiome and Mental Health
The intricate relationship between our bodies and minds is a subject of ongoing scientific exploration. Emerging research highlights a fascinating connection between the trillions of microorganisms residing in our gut – collectively known as the microbiota – and our mental well-being. This connection, often referred to as the gut-brain axis, is a bidirectional communication network where the gut influences the brain, and vice versa [65, 66]. The way that mental health issues are understood and addressed is greatly impacted by this intricate interaction. Recent research has focused on elucidating the intricate connections between the gut microbiota and various mental health conditions, including depression, bipolar disorder, anxiety, and stress-related disorders.
The Gut-Brain Axis is a Two-Way Street. The gut-brain axis involves a complex interplay of neural, hormonal, and immunological signaling pathways. The gastrointestinal [GI] flora, comprising bacteria, fungi, viruses, and other microorganisms, is not just a passive player in digestion. It actively communicates with the brain, influencing mood, stress response, and even cognitive function [67, 68]. This communication occurs through several routes, including the vagus nerve, which directly connects the gut to the brainstem. Factors such as stress and a high-fat diet can significantly alter the composition and function of the GI flora, which in turn affects brain function through the release of various signaling molecules [69]. For example, chronic stress can lead to a reduction in beneficial bacteria and an increase in harmful bacteria, disrupting the balance of the gut microbiome [70].
Our gut microbiota's makeup and function are significantly influenced by the foods we eat and the way we live. Consuming a lot of processed foods, sweets, and saturated fats can upset the delicate balance of the gut environment, which can lead to inflammation and the proliferation of dangerous bacteria. On the other hand, a diet high in fruits, vegetables, fiber, and fermented foods can promote a varied and healthy gut flora, which in turn supports mental health. In recent years, the Dietary Inflammatory Index was created to describe a person's diet on a scale ranging from pro-inflammatory to anti-inflammatory. Several research have looked into how the Dietary Inflammatory Index affects depression [121]. For example, a Mediterranean diet, rich in olive oil, nuts, vegetables, and fish, has been associated with improved mental health outcomes [122-126].
The gut microbiota affects mental health in a number of important ways:
Recent studies have employed various methodologies, including brain imaging, intervention trials, and observational studies, to investigate the gut microbiome's role in mental health. Brain imaging techniques have provided valuable insights into the gut-brain connection. Randomized controlled trials have investigated the effect of probiotic treatment on brain activity. For example, a four-week probiotic treatment with Bifidobacterium longum 1714TM showed differences in neural oscillations in the frontal and cingulate cortex during both resting-state and after social stress, with changes observed during resting state associated with higher self-reported vitality and reduced mental fatigue [82]. In contrast to a placebo, a different study employing a multispecies probiotic formulation revealed increased positive affect and variations in the BOLD [blood-oxygen level-dependent] signal pattern in response to emotional recognition memory tasks and emotional decision-making tasks [83]. Cross-sectional studies have also explored brain connectivity in relation to gut microbiota composition. Higher resting-state insular functional connectivity was associated with higher fecal bacterial microbiota diversity, lower abundance of Bacteroides, and higher abundance of Prevotella [84]. Prevotella abundance was higher, Bacteroides abundance was lower, and fecal bacterial microbiota diversity was higher when resting-state insular functional connection was higher [84]. Anatomical and functional connectivity of reward and anxiety-related regions was linked to elevated levels of fecal indole metabolites [85].
Depression:
Bipolar Disorder:
Studies assessing the gut microbiome in bipolar disorder have shown inconsistent results. Some studies have found BD to be associated with a decreased bacterial diversity when compared to healthy controls [107, 108, 109], while others found no difference [110, 111]. The results are also inconsistent in terms of predominant phyla in BD [107, 108, 109, 112, 113]. An open trial examining the impact of a multistrain probiotic in euthymic patients with BD revealed improvements in executive function, attention, and psychomotor processing speed [114]. This was the only published trial on probiotics in BD.
Anxiety and Stress Disorders:
By reducing the stress-induced decrease of Bifidobacterium spp. and the stress-induced increase of Streptococcus spp., a 4-week randomized controlled trial of long-term use of Lactobacillus gasseri CP2305 [CP2305] in healthy young adults revealed improvements in mental state, sleep quality, and gut microbiota under stressful conditions [115]. When comparing the probiotic group to the placebo group, another randomized controlled trial assessing the impact of multispecies probiotics on anxiety in healthy college students revealed improvements in neurophysiological anxiety, panic anxiety, negative affect, worry, and negative mood regulation [116]. Patients with generalized anxiety disorder have lower fecal bacterial alpha diversity, fewer operational taxonomic units, and reduced Firmicutes and Tenericutes abundances [117], as well as decreased short-chain fatty acid-producing bacteria and overgrowth of Escherichia-Shigella, Fusobacterium, and Ruminococcus gnavus [118] compared to healthy controls. Pregnant women that reported exposure to two or more adverse childhood experiences had a greater abundance of fecal Prevotella than pregnant women with none or only one adverse childhood experience [119]. An association between maternal pregnancy general anxiety and fecal microbiota composition has been observed [120].
Potential Therapeutic Applications
New therapeutic approaches have been made possible by our expanding knowledge of the gut-brain axis. Probiotics, which are live microorganisms intended to benefit the host, are being investigated as potential treatments for mood disorders [127]. Studies have shown that certain probiotic strains can reduce symptoms of anxiety and depression [128, 129]. Additionally, dietary interventions aimed at reducing inflammation and promoting a healthy gut microbiota are being explored as complementary approaches to mental health care. Prebiotics, which are non-digestible food ingredients that promote the growth of beneficial gut bacteria, are also being investigated for their potential to improve mental health. The use of dietary supplements, such as omega-3 polyunsaturated fatty acids [n-3 PUFAs], has also been explored for the treatment of depression [130].
The intricate relationship between the human microbiome and overall health is now undeniable. Our exploration has revealed the microbiome's far-reaching impact, extending beyond its well-established roles in physical health – from the gut and other organ systems like the esophagus, oral cavity, respiratory tract, skin, and reproductive system – to encompass the complexities of mental well-being, including connections to depression, bipolar disorder, anxiety, and stress-related conditions. The degree to which a healthy "whole of body" microbiome contributes to the occurrence of the disease states and syndromes described in this review highlights the importance of this ecosystem in terms of species number and composition. The bacteria in distinct niche-specific microbiomes interact with one another both within and between species, which helps them react to the host. Disease development and host harm can arise from microbial dysbiosis within niche-specific microbiomes.
But as more recent research has shown, communication along the axes connecting host sites is just as crucial. Axonal communication has now been directly connected to a number of illness states, and in some instances, like H. pylori and Parkinson's disease, the connection was very surprising. Regarding the axes of communication, the current view is that they are extensive and most likely involve all or most niche-specific microbiomes cooperating to alter host sites.
While significant progress has been made in understanding these associations, much remains to be discovered about the precise mechanisms at play. The future of microbiome research lies in translating these discoveries into practical applications. This includes developing personalized interventions, such as targeted prebiotics, probiotics, or even fecal microbiota transplantation, to restore microbial balance and promote health. As we continue to unravel the secrets of this complex ecosystem, we move closer to a new era of medicine where the microbiome is recognized not just as a collection of microbes, but as a powerful tool for optimizing human health and preventing disease.
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As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
