Etiology, Surgical Management, Identification of Bacterial Causes of Postoperative Infections, and Antibiotic Pattern of Isolates among Patients with Facial and Maxillofacial Fractures at time of Hardware Removal

Research Article | DOI: https://doi.org/10.31579/2768-2757/192

Etiology, Surgical Management, Identification of Bacterial Causes of Postoperative Infections, and Antibiotic Pattern of Isolates among Patients with Facial and Maxillofacial Fractures at time of Hardware Removal

  • Lutf Mohammed Al-Rahbi 1
  • Hend Naji Al-Sabri 2
  • Hassan Abdulwahab Al-Shamahy 3*

1Department of Oral and Maxillo-Facial Surgery, Faculty of Dentistry, Sana’a University, Republic of Yemen.

2Yemen Medical Specialist Council, Ministry of Health and population, Yemen.

3Departement of Basic Sciences, Faculty of Dentistry, Sana’a University, Republic of Yemen.

*Corresponding Author: Hassan Abdulwahab Al-Shamahy., Faculty of Medicine and Heath Sciences, Sana'a University.

Citation: Al-Rahbi LM, Al-Sabri HN, Al-Shamahy HA, (2026), Etiology, Surgical Management, Identification of Bacterial Causes of Postoperative Infections, and Antibiotic Pattern of Isolates among Patients with Facial and Maxillofacial Fractures at time of Hardware Removal, Journal of Clinical Surgery and Research, 7(1); DOI:10.31579/2768-2757/192

Copyright: © 2026, Hassan Abdulwahab Al-Shamahy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 18 November 2025 | Accepted: 19 December 2025 | Published: 01 January 2026

Keywords: bacterial causes, postoperative infections, antibiotic pattern, maxillofacial fractures, mandibular fracture, hardware removal

Abstract

Background and aims: A fracture of the mandible is referred to as a mandibular fracture or jaw fracture. The fracture occurs in two locations in approximately 60% of cases. This may result in decreased ability to open the mouth. The teeth often feel misaligned, and the gums may bleed. This study aimed to determine the etiology of fractures, surgical management, bacterial causes of postoperative infection, and the antibiotic profile of bacteria isolated from maxillofacial fracture patients at the Military Hospital in Sana'a.

Materials & methods: Between January 1, 2024, and the end of December 2024, this study included patients with maxillofacial fractures at the Military Hospital in Sana'a, Yemen, where the Department of Oral and Maxillofacial Surgery conducted the study. Thirty patients received treatment with fracture fixation devices. Patients underwent treatment and follow-up six months after surgery. The incidence of postoperative bacterial infections at surgical sites after removal of the devices was assessed. Isolates were identified using standard microbiological methods, and antibiotic susceptibility testing was performed using the Kirby-Bauer technique. Clinical and demographic data of the study participants were also collected.

Results: The study reveals that the majority of patients with maxillofacial fractures in Sana'a, Yemen, were aged 20–24 years, with a mean ± standard deviation of 29.9 ± 12.4 years. All were male, with gunshot wounds and road transport accidents being the most common causes. Most fractures were open compound fractures (56.7%), all of which were mandibular fractures. Open reduction internal fixation (ORIF) was the most common surgical treatment performed in 60% of patients. The most common bacteria isolated from surgical sites was Staphylococcus aureus, accounting for 27 (90%) of all isolates, followed by Klebsiella pneumoniae at 30%, while three cases (10%) showed no bacterial growth. Amoxicillin, Augmentin, Aztreonam, Cefotaxime, Cefoxitin, Ceftazidime, Piperacillin, Ceftriaxone, and Doxycycline were completely ineffective against S. aureus isolates. Vancomycin had the highest sensitivity rate against S. aureus, at 100%. Amoxicillin, Augmentin, cefotaxime, cefoxitin, ceftazidime, ceftriaxone, cotrimoxazole, and gentamicin had no effect on Klebsiella pneumoniae isolates, while the sensitivity rate for amikacin was 33.3% and for ciprofloxacin 33.3%.

Conclusion: The study found that males were 100% more likely to suffer mandibular fractures, with the majority of cases occurring in those aged 20 to 24 (56.7%). Gunshot wounds were the most common cause. The most commonly isolated bacteria was Staphylococcus aureus, with a very high rate of multidrug resistance. Vancomycin was found to be the most reliable drug for treating Staphylococcus aureus infections.

Introduction

Maxillofacial injuries are among the most common life-threatening emergencies in both developing and developed countries, accounting for between 7.4% and 8.7% of emergency medical care [1]. These injuries affect both the skeletal structures and soft tissues of the facial region and can cause significant and long-term functional, aesthetic, and psychological complications [2]. Due to the prominent location of the maxillofacial region, it is the most susceptible to fractures. The mode of injury and the direction of trauma determine the pattern and location of these fractures [3]. Fractures of the maxillofacial skeleton alone are rarely fatal, but concomitant injuries to other organs can be a complicating factor. Other severe ailments as neurological, orthopedic, and ophthalmological damage frequently accompany maxillofacial fractures [4]. Due to their near proximity to critical organs including the brain and cervical vertebrae, these injuries are frequently linked to significant morbidity; nevertheless, they can also result in loss of function, impairment, and even death [5]. In terms of severity and causation, the epidemiology and etiologies of face fractures differ amongst populations [6]. RTA and assault have been identified as the primary causes of craniofacial fractures in adults, whereas falls were the most often reported cause in younger people [7]. Comprehending maxillofacial trauma facilitates the evaluation of individuals' behavior patterns across nations and aids in the development of efficient strategies for managing and preventing injuries [8]. Surgical wound infections can be external (skin), deep (muscle and tissue), or extend to the organ or location of the surgery [9]. Surgical wound infections are frequently detected and can arise in the first 30 days following surgery, regardless of whether the bacteria were previously on the patient's skin – mucus membrane of the mouth or if they were transferred to the patient from the hospital environment or from contact with infected individuals. According to recent studies, postoperative infections can happen years after surgery, and these infection rates go unreported for a variety of reasons, including missing patient follow-up, having trouble accessing a prior surgical history, seeing a different surgeon, not meeting national records requirements, and more [10,11,12]. The CDC has divided SSIs into three categories: infections affecting organs or bodily spaces, deep wound infections, and superficial infections. The likelihood of an SSI is influenced by the level of contamination present at the surgical site at the time of the procedure. Wounds are categorized as clean, contaminated, unclean, or infected based on the degree of contamination and its incidence [13]. Because of the diverse character of this surgical infection, SSI epidemiology research provide difficulties. There are significant differences in prevalence among procedures, facilities, patients, and surgeons [14]. Both internal and foreign microbes have the ability to alter the SSI. The majority of surgical site infections are brought on by endogenous germs that are present on the patient's skin at the time of the surgical incision. The most frequent bacteria that cause skin infections are gram-positive ones, such as Staphylococcus aureus. Microorganisms within the patient's body that are exposed during surgery are more likely to be the source of SSIs. Pathogens vary according to the surgical location; for example, gastrointestinal tract surgery increases the risk of SSI from Gram-negative intestinal germs [15]. Given the risk factors for SSI, the study literature acknowledges a number of linked variables; yet, investigations are not replicable. Despite this, a number of publications have often identified significant blood loss, male sex, and advanced age as risk factors for SSI [16–19]. Additional risk factors for SSI are often categorized as postoperative, procedure-related (peri-operative), and patient-related (preoperative). In general, patient-related risk factors for surgical site infection (SSI) can be classified as either modifiable or non-modifiable. Patient-related variable risk factors include poor diabetes control, use of immunosuppressive medications, obesity, tobacco use, and length of preoperative hospitalization. Procedure-related risk factors include wound type, surgical site haircut, hypoxia, length of surgery, and hypothermia. Non-modifiable or modifiable risk factors, such as age and gender, have been considered [20]. Although previous research has been conducted on bacterial profiles, antibiotic sensitivity, and risk factors for UTI in postoperative patients at specialized hospitals in Sana'a, Yemen [21], as well as one study on general SSI, there is no information regarding SSI in maxillofacial surgery in Yemen. Therefore, this study aimed to determine the prevalence and distribution of bacterial pathogens isolated of SSI associated with postoperative wounds of maxillofacial surgery and their antimicrobial susceptibility profiles in selected hospitals in Sana'a City, Yemen.

Material And Methods

A serial, comparative clinical follow-up study was conducted. This study comprised patients who presented with trauma at the military hospital's maxillofacial surgery department between January 1, 2023, and December 31, 2023. Age, sex, socioeconomic position, primary complaint, history of current sickness, history of previous medical conditions, length of injury, etiology, and related injuries were all detailed. Following data collection, each patient in this research underwent a comprehensive clinical examination and radiological interpretation in order to make a diagnosis.

Data collection methods

Physical examination of patients was performed by an experienced MSc student to check for the presence of local infection based on one or more of the following criteria: pain, tenderness, local swelling, redness, warmth or purulent discharge, evidence of abscess, or fever greater than 38°C in deep incisions. Specimen Collection: Wound swabs or aspirates were aseptically collected from surgical sites of patients presenting for medical examination and removal of fixed orthopedic appliances. This was done prior to wound treatment with antiseptic solution. Specimens were then placed in 5 ml Stewart transport media and transported to the Bacteriology Department at the National Center for Public Health Laboratories for bacteriological testing.

Bacterial Isolation and Identification 

The samples underwent test methods in accordance with accepted bacteriological practices for aspirates and swabs [22].  Using the conventional streak plate method, the samples were inoculated into blood agar, Mannitol salt agar, and MacConkey agar (Oxoid). For 24 to 48 hours, the plates were incubated at 37°C in an anaerobic environment.  Colony morphology, pigment generation, blood hemolysis (beta, alpha, and gamma hemolysis), biochemical tests (lactose, mannitol, glucose, and sucrose fermentation), and motility property testing were used to validate bacterial growth on medium. Because mannitol salt agar is a selective medium for Staphylococcus, bacteria growing on both blood agar and mannitol salt agar are thought to be Gram-positive bacteria. To differentiate streptococcus from staphylococci, a catalase test was next conducted; streptococcal species were ruled out if the test yielded negative findings. Additionally, to differentiate S. aureus from other Staphylococcus species that test negative for coagulase, a coagulase enzyme test was performed. Because MacConkey agar is a selective medium for Gram-negative bacteria, microorganisms produced on it and blood agar are thought to be Gram-negative bacteria. The lactose fermentation characteristics of the colonies on MacConkey agar were used to characterize them. The colorless colonies were lactose-non-fermenters, whereas the pink-colored colonies were lactose fermenters. Using a variety of biochemical assays, such as indole, urea, Triple Sugar Iron agar (TSI), Simmon's Citrate agar, and Lysine Decarboxylase (LDC), gram-negative bacteria were further examined for motility and characterization.  To confirm that P. aeruginosa is an oxidase-positive bacterium, oxidase was used to evaluate colonies that generated color on blood agar and non-lactose fermenter on MacConkey agar.  Using a variety of biochemical tests, such as triglyceride iron agar (TSI), indole, urea, Simmon's Citrate agar, and Lysine Decarboxylase (LDC), gram-negative bacteria were also examined for their motility and ability to distinguish.  Oxidase was used to confirm P. aeruginosa (oxidase-positive bacterium) in colonies that produced color on blood agar and non-lactose fermented on MacConkey agar. Testing for Antimicrobial Susceptibility Mueller-Hilton agar (Oxoid) was used in the Kirby-Bauer diffusion technique to examine the isolates' patterns of antibiotic susceptibility. Five milliliters of nutrient broth were used to suspend four to five bacterial colonies with the same shape. After that, the suspension's turbidity was brought down to 0.5 McFarland, which produced a colony count of around 107 or 108 colony-forming units per milliliter. After inserting a sterile swab into the solution and pushing it against the tube's walls to remove any excess, the swab was infected directly in the middle of the Mueller-Hilton agar plate and then equally distributed to produce confluent growth. MuellerHilton agar was aseptically supplemented with 5?fibrinated sterile blood to test for streptococci susceptibility [22]. The relevant anti-microbial susceptibility discs were aseptically positioned and gently pushed against the medium for complete surface contact using sterile forceps after the infected plates had dried for three to five minutes. Approximately 24 mm separated the discs, and 15 mm separated them from the plate's border, to prevent the region of inhibition from overlapping. For 18 to 24 hours, the plates were incubated aerobically at 37 °C in the incubator [23]. Using a digital caliper, the diameter of the zone of inhibition for each antibiotic was measured to the closest millimeter (Market lab, UK). The diameter of the inhibition zone of tested bacteria around the disc was measured to the nearest millimeter, and then classified as sensitive and resistant according to Cheesbrough [22]  and the Clinical Laboratory Standard Institute guidelines of 2015 [23] . The antimicrobial susceptibility discs (Oxoid, Ltd, UK) includes; Amikacin (30 μg), Clarithromycin (30 μg), Amoxicillin-clavulanic acid (30 μg), Ampicillin (10 μg) Penicillin (30 μg), Erythromycin (15 μg), Ceftriaxone (30 μg), Cefixime (30 μg), Ceftazidime (30 μg), Cefotaxime (30 μg), Cefepime (30 μg), Gentamicin (10 μg), Ciprofloxacin (5 μg), Norfloxacin (10 μg), and Cotrimoxazole (25 μg) Imipenem (30 μg), Aztreonam (30 μg), Rifampicin (30 μg), and Vancomycin (30 μg).

Data analysis

The data were analyzed with Epi Info version 6 (CDC, Atlanta, USA). The continuous variable (age) was summarized with mean and standard deviation while the categorical variables were summarized with frequencies and proportions and presented as tables. 

Ethical Consideration: 

The Medical Ethics and Research Committee of Sana'a University's Faculty of Dentistry granted ethical permission for this project (No. 12 dated December 1, 2023). Every process complied with the review committee's ethical standards. Consent was also obtained from each participant, who was told that participation was entirely optional and that they might decline at any time for any reason.

Results

Table (1) shows the age distribution of maxillofacial fracture patients treated with devices in the 48 hospital. The mean ± standard deviation of the patients was 29.9 ± 12.4 years, and their ages ranged from 20 to 57 years. Table  2 shows the sex distribution of maxillofacial fracture patients treated with devices in the military hospital. All patients were males and no single case of females. Table 3 shows the causes and incidence of facial and maxillofacial fractures in patients treated with devices at the 48 hospital. The most common cause was gunshot wounds, accounting for 50% of all cases, followed by traffic accidents (20%), bomb explosions (16.7%), and pathological fractures (13.3%). No cases of falls from height were recorded. The kinds of fractures among head injuries in patients receiving device treatment at the 48 hospital are displayed in Table 4. There were 43.3% of closed simple fractures and 56.7% of open complicated fractures. Table 5 lists the locations of head injuries among patients receiving device treatment in 48 institutions; all of the fractures were mandibular. Table 6 shows the types of procedures used for device removal in patients treated with devices at the military hospital . The most common procedures were reconstructive plate counting (60%), followed by miniplate counting (30%), while titanium mesh was used in only three cases (10%). Table 7 shows the clinical examination of fracture patients treated with devices at 48 hospitals. Pain at the fracture site was observed in 33.3%, fever in 36.7%, chills in 3.3%, night sweats in 43.3%, skin erythema in 46.7%, purulent discharge in 70%, pain at the fracture site in 20%, and movement at the fracture site in 10% of all cases. Table 8 shows the surgical treatments for fracture patients treated with instrumentation at Hospital 48. Open reduction internal fixation (ORIF) alone was the most common surgical treatment performed in 60% of patients, followed by open reduction internal fixation with intermaxillary fixation (IMF) at 40%, while no case was performed using open reduction internal fixation with bone grafting (0%). Table 9 shows postoperative bacterial infections from the surgical site in instrumented fracture patients at Hospital 48. The most common bacteria isolated from the surgical site was Staphylococcus aureus, accounting for 27 (90%) of the total isolates, followed by Klebsiella pneumoniae at 30%, while 3 cases (10%) showed no bacterial growth. The antimicrobial susceptibility pattern of the isolated Staphylococcus aureus (n=27) is displayed in Table 10.  Amoxicillin, Augmentin, Aztreonam, Cefotaxime, Cefoxitin, Ceftazidime, Piperacillin, Ceftriaxone, and Doxycycline were all completely ineffective against the Staphylococcus aureus isolates. Vancomycin had the highest sensitivity rate of any antibiotic against S. aureus, at 100%. Teicoplanin had the next highest sensitivity rate, at 88.9%, followed by Tobramycin at 55.5%, Gentamicin at 66.7%, and Co-trimoxazole at 55.5%.  The sensitivity rates of S. aureus to various antibiotics varied from 22.2% to 59.3%. The antibiotic susceptibility pattern of the isolated Klebsiella pneumoniae (n=9) is displayed in Table 11. Amoxicillin, augmentin, cefotaxime, cefoxitin, ceftazidime, ceftriaxone, co-trimoxazole, and gentamicin did not work at all on the Klebsiella pneumoniae isolates. Klebsiella pneumoniae has a 33.3% sensitivity rate to amikacin and a 33.3% sensitivity rate to ciprofloxacin.

Age groupN%
20-24 years1240
25-29 years930
≥30 years930
Mean age29.9 years 
SD12.4 years 
Mode20 years 
Median28 years 
Min to Max20-57 years 
Total10100

Table 1: Age distribution of maxillofacial fracture patients treated with devices in 48 hospitals (n = 30).

SexN%
Male30100
Female00.0
Total30100

Table 2: Sex distribution of maxillofacial fracture patients treated with devices in 48 hospitals (n = 30).

Mode of injuryN%
Road traffic accidents620
Fall from height00
Gunshot1550
Bomb explosion516.7
Pathological fractures413.3
Total30100

Table 3: Causes and mode of occurrence of maxillofacial fractures in patients treated with devices in 48 hospitals (n = 30).

Types of fracturesN%
Closed simple fractures1343.3
Open compound fractures1756.7
Total30100

Table 4: The types of fractures among head injury in patients treated with devices in 48 hospitals (n = 30).

Site of fracturesN%
Frontal bone fracture00
Nasal bone fracture00
Orbital bone fracture00
Zygomatic fracture00
Maxillary fracture00
Mandibular fracture30100
Total10100

Table 5: The sites of fractures among head injury in patients treated with devices in 48 hospitals (n = 30).

ManagementsN%
Reconstructive plate1860
Mini-plate930
Titanium mesh310
Total30100

Table 6: Managements of infected hardware and types of hardware removal in patients treated with devices in 48 hospitals (n = 30).

SymptomsNo%
Pain at site of fracture1033.3
Fever1136.7
Chills13.3
Night sweating1343.3
Erythema1446.7
Purulent discharge2170
Tenderness620
Motion at fracture site310
Total30100

Table 7: Clinical examination of fracture patients treated with devices in 48 hospitals (n = 30).

Surgical managementsN%
Open reduction internal fixation (ORIF) alone1860
ORIF with bone graft00.0
ORIF with Intermaxillary fixation (IMF)1240
Total30100

Table 8: Surgical managements for fracture patients treated with devices in 48 hospitals (n = 30).

Bacteria isolatesN%
Staphylococcus aureus2790
Klebsiella pneumoniae630
No growth310
Total30100

Table 9: postoperative bacterial infections from Site of surgery in fracture patients treated with devices in 48 hospitals (n = 30).

AntibioticsSensitive N (%)Resistant N (%)
Amikacin9/27 (33.3)18/27 (66.7)
Amoxicillin0/27 (0.0)27/27 (100)
Augmentin0/27 (0.0)27/27 (100)
Aztreonam0/27 (0.0)27/27 (100)
Cefotaxime0/27 (0.0)27/27 (100)
Cefoxitin0/27 (0.0)27/27 (100)
Ceftazidime0/27 (0.0)27/27 (100)
Ceftriaxone0/27 (0.0)27/27 (100)
Ciprofloxacin3/27 (11.1)24/27 (88.9)
Co-trimoxazole15/27 (55.5)12/27 (44.4)
Doxycycline0/27 (0.0)27/27 (100)
Erythromycin6/27 (22.2)21/27 (77.7)
Gentamicin18/27 (66.7)9/27 (33.3)
Levoflxacin16/27 (59.3)11/27 (40.7)
Linezolid15/27 (55.5)12/27 (44.4)
Moxifloxacin12/27 (44.4)15/27 (55.5)
Piperacillin0/27 (0.0)27/27 (100)
Tetracycline6/27 (22.2)7/9 (77.7)
Vancomycin27/27 (100)0/27 (0.0)
Tobramycin15/27 (55.5)12/27 (44.4)
Clindamycin6/27 (22.2)21/27 (77.7)
Teicoplanin24/27 (88.9)3/27 (11.1)

Table 10: Antimicrobial susceptibility pattern of the isolated Staphylococcus aureus (n=27)

AntibioticsSensitive N (%)Resistant N (%)
Amikacin3/9 (33.3)6/9 (66.7)
Amoxicillin0/9 (0.0)9/9 (100)
Augmentin0/9 (0.0)9/9 (100)
Cefotaxime0/9 (0.0)3/3 (100)
Cefoxitin0/9 (0.0)9/9 (100)
Ceftazidime0/9 (0.0)9/9 (100)
Ceftriaxone0/9 (0.0)9/9 (100)
Ciprofloxacin3/9 (33.3)6/9 (66.7)
Co-trimoxazole0/9 (0.0)9/9 (100)
Gentamicin0/9 (0.0)9/9 (100)

Table 11: Antimicrobial susceptibility pattern of the isolated Klebsiella pneumoniae (n=9).

Discussion

The prevalence of maxillofacial injuries has increased in both urban and rural regions, and both industrialized and developing nations have seen a shift in this trend [24]. RTA has been identified as the primary cause of maxillofacial injuries in underdeveloped nations [26], whereas interpersonal violence has been identified as the primary cause in affluent nations [25]. Epidemiological assessments are said to be more precisely necessary for the execution of preventative measures and the efficacy of treatment. Additionally, coordinated, recurring, Men were more impacted  than women in this study, which is more than the ratio of 4.6:1 reported in Bulgaria (Bakardjiev and Pechalova); [27] in China (Mijiti et al.); [28] in Jordan; 3:1 (Bataineh); [29] and 2.1:1 in an Austrian study (Gassner et al.). [30]. Additionally, this ratio was larger than what was reported in several Saudi research; in one study, it was 4.8:1 (Rabi and Khateery) [31], while in another, it was 4.4:1 (Al-Masri et al.) in Jeddah. [32]. Conversely, this ratio was lower than the Indian report. In the southern part of Saudi Arabia, in Abha City (Al-Masri) [32], the ratio was reported to be 10:1, while in Jeddah (Jan et al.), [35], it was 6:1. Shanker et al. [33] and Motamedi et al. [34] recorded an 8:1 ratio. This difference may be related to cultural reasons. In the war in Yemen, women are completely prohibited from participating in combat, while men participate in the war. Gunshot wounds accounted for 50% of all cases in the current research, making them the most prevalent cause. Traffic accidents (20%), bomb blasts (16.7%), and pathological fractures (13.3%) were next in line. There were no documented instances of falls from a height. In contrast to other findings in other countries (Brasileiro and Passeri; [36] Mijiti et al.; [28] Motamedi et al. [34]) and Saudi Arabia (Nwoku and Oluyadi; [37] Abdullah et al.; [38] Al-Masri [32], where road traffic accidents were the primary cause, the current study found that road traffic accidents were the second major cause of maxillofacial fractures. Gunshot wounds were the most frequent cause in the current study, but bomb blasts and assaults were the primary source of injuries in studies conducted in Germany (Schneider et al.), Bulgaria (Bakardjiev and Pechalova), Australia (Cabalag et al.), and [27]. [40] Gunshots are seen as a serious public health concern in Yemen because to the ongoing conflict and the rising number of gun owners there. Driver error was found to be the primary contributor to road accidents in Yemen, primarily due to underage driving. Alcohol and drug use are not common causes of road accidents, as these substances are prohibited in Yemen. In the current study, traffic accidents accounted for 20% of the total causes of road accidents, with human error and vehicle mechanical failures being the primary causes. Therefore, in light of the findings of this study, as well as previous similar research conducted in other regions of Yemen, reducing road accidents requires strict enforcement of the law and national public awareness initiatives in Yemen. A continuous educational program is required to inform treating physicians about the recent use of aggressive treatment with appropriate antibiotics to prevent the occurrence of such cases. It is also important to note that the four cases of pathological mandibular fractures that were reported were caused by chronic osteomyelitis. In the current study, the locations of head injuries in patients treated with the device were identified; all fractures were mandibular. The prevalent mandibular fracture in our study is similar to other findings reported in other parts of the world (Brasileiro and Passeri; [36] Bakardjiev and Pishalova; [27] Megeti et al. [28], as well as some Middle Eastern countries (Motamedi et al. [34]), and Saudi Arabia (Abdullah et al. [38] Al-Masry [32]). However, these findings are inconsistent with those from Australia (Cabalag et al. [39]), which reported that the majority of patients suffered orbital fractures, a study in Germany (Schneider et al. [40]), where midfacial fractures with orbital floor injury were the most common, and a Saudi study at the Armed Forces Hospital in Riyadh (Nwoku and Oluyadi) [37], which reported that midfacial fractures were significantly higher than mandibular fractures. The difference in the affected bone may be related to the different causes reported in different studies in which gunshot was the most cause in the current study. The mandibular body fractures were the most commonly reported broken portion of the maxillofacial bones in this investigation, which is consistent with the findings of Haug et al. [6] According to a different research by Mijiti et al. [28], following mandibular body fractures, symphysis was the second most common location for mandibular fractures. In one research, Brasileiro and Passeri found that the most common locations of mandibular fractures were condylar fractures followed by symphysis fractures [36], whereas Motamedi et al. found that the most common sites were symphysis–parasymphysis fractures followed by condylar fractures [34]. The mechanism and direction of the impact at the moment of the accident may be responsible for this variation in the most afflicted area. Open reduction internal fixation (ORIF) was performed for the majority of patients in the current study (60%). This is similar to the results of a study in India (Bali et al.), [7] who reported that 62.2% of affected patients were treated with ORIF; and in China (Meghetti et al.), [28] the percentage was 62.4%. Of the 1024 cases retrospectively studied by Brasileiro and Passeri [36] in Brazil, 48% were treated conservatively and approximately another 48% were treated surgically, primarily with ORIF. Conversely, closed reduction was the most common treatment method in several other studies (Bataine; [29] Bakardjiev and Pichalova [27]). According to this study, S. aureus was the most often isolated species (90%) in the study. The results are greater than those of studies in Ethiopia, where the percentages of S. aureus were 33.3% [16] and 26.2% [18], while the research in Uganda showed that K. pneumonia was the most common isolate, with a 50% rate [41]. Variations in common hospital-acquired infections, as well as policies and recommendations for infection prevention and management among nations and wound sites, may be the cause of this discrepancy in the distribution of bacterial species. The Staphylococcus aureus isolates in this investigation were fully ineffective against Amoxicillin, Augmentin, Aztreonam, Cefotaxime, Cefoxitin, Ceftazidime, Piperacillin, Ceftriaxone, and Doxycycline. With a 100% sensitivity rate against S. aureus, vancomycin was the most effective antibiotic. The next highest sensitivity rate was 88.9% for Teicoplanin, followed by 55.5% for Tobramycin, 66.7% for Gentamicin, and 55.5% for Co-trimoxazole. These antibiotics were found to be reasonably effective in treating S. aureus-caused SSIs, which is in line with a study that was previously published in Yemen by Alhadi et al. [42], Al-Makdad et al. [21], and in Ethiopia by Gelaw et al. [43]. Conversely, the AlShami et al. investigation found that these medications were less effective [44]. It is possible that the increase in antibiotic resistance brought on by the irrational use of anti-infective medications, insufficient controls to prevent the spread of infections, variations in common hospital-acquired pathogens, and the acquisition of organisms resistant to antibiotics are linked to both the duration of exposure to these microorganisms and the presence of risk factors. Additionally, the current investigation showed that the Klebsiella pneumoniae isolates were completely unaffected by amoxicillin, augmentin, cefotaxime, cefoxitin, ceftazidime, ceftriaxone, co-trimoxazole, and gentamicin. Amikacin and ciprofloxacin sensitivity rates for Klebsiella pneumoniae are 33.3% and 33.3%, respectively. These findings contrast nearly entirely from those previously published in Yemen [21,45–49], where the sensitivity rates for the aforementioned investigations were provided. The current study demonstrates that Gram-negative bacteria, especially Klebsiella pneumoniae, are alarmingly resistant to the polyclonal antibiotics Amoxicillin, augmentin, cefotaxime, cefoxitin, ceftazidime, ceftriaxone, co-trimoxazole, and gentamicin (100%). This resistance rate was higher than that of earlier studies carried out in Yemen [45–49]. This might be because the development and spread of resistance are mostly caused by the experimental treatment of isolates, the haphazard and frequent use of these antibiotics by inexperienced practitioners, and the absence of antibiotic usage standards [21,44,50].

Conclusion

The study found that males were 100% more likely to suffer mandibular fractures, with the majority of cases occurring in those aged 20 to 24 (56.7%). Gunshot wounds were the most common cause. The most commonly isolated bacteria was Staphylococcus aureus, with a very high rate of multidrug resistance. Vancomycin was found to be the most reliable drug for treating Staphylococcus aureus infections.

Limitations of the study

The main limitation of this study was the small sample size included with short -term follow-up.

Data Availability

The accompanying author can provide the empirical data that were utilized to support the study's conclusions upon request.

A Dispute of Interest

There are no conflicts of interest in regard to this project.

Author’s Contributions

Dr. Hend Naji Al-Sabri: Formal analysis, conceptualization, data organization, and clinical and laboratory examinations to obtain a board’s degree in Oral and Maxillofacial Surgery. Lutf Mohammed Al-Rahbi: conceptualization, data organization, supervised the work. Hassan Abdulwahab Al-Shamahy reviewed the article, and approved the final version.

References

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Ziemlé Clément Méda

Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.

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Mina Sherif Soliman Georgy

We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.

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Layla Shojaie

The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.

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Sing-yung Wu

Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.

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Orlando Villarreal

Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.

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Katarzyna Byczkowska

Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.

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Anthony Kodzo-Grey Venyo

Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.

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Pedro Marques Gomes

Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.

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Bernard Terkimbi Utoo

This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.

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Prof Sherif W Mansour

Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.

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Hao Jiang

As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.

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Dr Shiming Tang

Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.

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Raed Mualem

International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.

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Andreas Filippaios

Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.

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Dr Suramya Dhamija

Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.

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Bruno Chauffert

I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!

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Baheci Selen

"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".

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Jesus Simal-Gandara

I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.

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Douglas Miyazaki

We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.

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Dr Griffith

I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.

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Dr Tong Ming Liu

I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.

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Husain Taha Radhi

I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.

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S Munshi

Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.

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Tania Munoz

“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.

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George Varvatsoulias

Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.

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Rui Tao

Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.

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Khurram Arshad

Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.

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Gomez Barriga Maria Dolores

The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.

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Lin Shaw Chin

Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.

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Maria Dolores Gomez Barriga

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.

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Dr Maria Dolores Gomez Barriga

Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe

Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed

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Mahmoud Kamal Moustafa Ahmed

Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.

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Dr Elena Salvatore

Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal

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Christoph Maurer

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.

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Baciulescu Laura

Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.

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Dr Mamoun Magzoub

International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.

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Joel Yat Seng Wong

Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.

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Dr Perlat Kapisyzi

Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha

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Sabita sinha

Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.

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Dr Ted Christopher