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Review Article | DOI: https://doi.org/10.31579/2768-0487/198
1Genetic Resources Institute, Department of Physiology Genetics, Baku, Аzerbaijan.
2Khazar University, Baku, Azerbaijan Ramiz Aliyev.
*Corresponding Author: Afet Dadash Mammadova., Genetic Resources Institute, Department of Physiology Genetics, Baku, Аzerbaijan.
Citation: Afet Dadash Mammadova, Ramiz Aliyev, (2026), Adaptive Response of Cotton to Salinity Stress, Journal of Clinical and Laboratory Research, 9(1); DOI:10.31579/2768-0487/198
Copyright: © 2026, Afet Dadash Mammadova. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 24 December 2025 | Accepted: 02 January 2026 | Published: 06 January 2026
Keywords: stress; salinity; cotton; degree of resistance; rna; dna fractions
The article presents the results of studying the adaptive response of collection varieties of cotton of the species G.barbadense L. to salt stress. The degree of resistance of collection cotton accessions to salt stress was studied based on the indices of seed germination in an osmotic solution. The studies have shown that varieties of the same species differed significantly in the amplitude of the physiological parameter. The reaction of the samples to the action of an unfavorable environmental factor made it possible to conditionally divide the samples into groups within the species, determining different degrees of comparative resistance. The nature of nucleic acid synthesis, including the fractional composition of DNA, was studied in cotton accessions characterized by different degrees of stress resistance. The study showed that in salt-tolerant accessions, stress causes activation of RNA synthesis and total, labile, residual DNA fractions, a decrease in the amount of stable DNA, which indicates an increase in physiological lability and functional activity of the genetic apparatus. In stress-sensitive varieties, a decrease in RNA and DNA synthesis is observed, and the ratio of DNA fractions shifts towards stability. The obtained data indicate the influence of stress factors on the structure and functional activity of the plant genome.
The action of environmental stress factors can cause numerous structural and functional changes that are initially aimed at ensuring the survival of the organism. Among these changes, the reaction of the genetic apparatus plays a significant role, on which largely depends what proteins, with what intensity and sequence will be synthesized by the cell in the current situation. [Kuhlemeier and Green, 1987; Kuznetsov and Shevyakova, 2006). Processes occurring at the level of transcription and translation quickly respond to stressful environmental conditions (Blekhman and Shelamova, 1992; Bhoite et al., 2025). The reaction of the genetic apparatus to changes in environmental conditions first became known in the early 1960s thanks to the research of the Italian geneticist Rittosa (Rittosa, 1962). There are reports in the literature on the nature of changes in the genetic material of plants under the influence of abiotic environmental factors (Munns, 2005; Aroca et al., 2006; Chhapekar and Gorakshnath, 2024). Of particular interest is the potential of the eukaryotic genome, which, as is known, is in a highly repressed state at any period of ontogenesis. Mass "reading" of information occurs simultaneously on a very small part of genes, the composition of which differs in different types of tissues (Kulaeva, 1988). When environmental conditions change, a program of selective gene expression is implemented and mechanisms of genetic determination of plant resistance to stress are carried out. Such a program is implemented in the system of a whole cell. The first studies of gene expression, which is a rapid response of the organism, in higher plants date back to the mid-70s of the 20th century. Nagle (Nagl, 1976) discovered that the transition of genes from an inactive state to an active one and vice versa depends on a wide variety of factors – photoperiodic lighting regime, temperature, the action of growth stimulants and inhibitors, the cationic composition of the environment, and others. A few minutes of the body's stay in unfavorable conditions is enough to restructure the genetic apparatus to ensure the possibility of synthesizing stress proteins (Kosakovskaya, 2008). Molecular analysis of global genome expression revealed that Arabidopsis root cells respond to salinity by altering the transcription of 5590 genes. Moreover, the most serious events in changes in gene expression are observed during the first 3 hours of salt exposure (Geng Yu., 2013). Thousands of NaCl-regulated genes encode ion transporters, ion and water channel proteins, and ATP transport enzymes, which are necessary for restoring the water potential gradient in the soil-plant system disrupted by salinity, maintaining intracellular water homeostasis, and overcoming salt-induced ion imbalance, as well as the biosynthesis of osmoregulators and multifunctional stress-protective compounds (Almikhlafi, 2014). Islam and his colleagues (Islam, 2009) having studied the effect of abiotic stress on the expression in rice of the gene encoding a protein containing a zinc finger domain, encoding a protein 171 amino acid residues long, noted a strong induction of the expression of the OsZFP gene in the roots and leaves of plants under salinity, and concluded that OsZFP, as a transcription factor, can play an important role in the response of rice to salinity. Analysis of the transcriptome composition of plants exposed to high temperature, drought, cold, salinity, strong light or mechanical stress showed that only a few genes respond to these stresses in a similar way (Kreps et al., 2002) Almost all plants respond to the action of any stressor by activating different groups of genes and synthesizing the protective proteins they encode. Plants contain a huge number of genes regulated by water deficiency and encoding various proteins: regulatory, protective (chaperones), enzymes. In addition to the synthesis of shock proteins, which shows that a special program associated with experiencing stress is recorded in the genome, the content of carbohydrates and proline in cells increases, which participate in protective reactions, stabilizing the cytoplasm. The accumulation of proline as an osmotically active organic substance promotes the retention of water in the cell. The effect of salinity leads to a decrease in free water in cells, which changes the hydration membranes of cytoplasmic proteins and affects the functioning of enzyme proteins (Hayat et all., 2012; Hualpa-Ramirez et al., 2024). The activity of synthesis enzymes decreases and hydrolytic processes are activated, which leads to an increase in the number of low-molecular proteins. As a result of the hydrolysis of polysaccharides, soluble carbohydrates accumulate in the cells, the outflow of which from the leaves is slowed down. The amount of RNA decreases (due to inhibition of its synthesis and activation of ribonucleases). The disintegration of polyribosome complexes is underway. Long-term exposure to stress can cause changes in the structure of DNA. The survival of a plant under conditions of excessive salinity depends not on the tolerance of the proteins themselves, but on their microenvironment, the ability of cells to maintain ionic homeostasis. Compatible osmolytes (sugars, sugar alcohols, free amino acids, etc.) lower the water potential, protect membranes, enzymes, structural and regulatory macromolecules. The increase in the concentration of these substances occurs due to the activation of genes that control enzymes synthesizing osmolytes and the inhibition of the expression of other genes responsible for their destruction (Gold et al., 2008). Salt stress is accompanied not only by osmotic, but also by the toxic effect of excess ion content (Sairam and Tyagi, 2004). High concentrations of salts, a decrease in the osmotic potential of soil solutions, lead to water deficiency in plants, while Na+ and Cl- ions have a direct toxic effect on plant cells. As a result of the interaction of salts with nutrients, an imbalance and nutritional deficiency are observed (Zhu, 2001). It should be noted that the selection of salt-tolerant forms in field conditions is complicated by the uneven distribution of saline areas (Munns, 2005). The study of nucleic acid metabolism is of great importance in connection with the clarification of the mechanisms of adaptation of plant organisms to stress. The aim of this study was to study the adaptive capacity of cotton collection material to salt stress, as well as to study changes in the structural state of DNA and the activity of nucleic acid synthesis in connection with the degree of resistance to salinity stress in cotton collection samples.
The objects of the study were collection samples of cotton of the species G.barbadensе L.
The method of germinating cotton seeds in a solution with an osmotic pressure of 0.2 M NaCl was used as an indicator of plant resistance to salinity (Udovenko, 1988). The percentage of germinated seeds (P) is determined as follows: the average number of germinated seeds in the control is taken as 100%, the average number of germinated seeds in the experiment (a) is expressed as a percentage of the number of germinated seeds in the control (b). Thus, P=a/b 100% The nucleic acid content was determined by DNA fractionation based on the principle of stepwise action on chromatin by solutions of different ionic strength and deproteinization factors, which allows dividing cellular DNA into labile (functionally active) or weakly bound in the chromatin structure and stable, completely blocked by histones, as well as residual or tightly bound. Extraction of labile DNA. Leaves were ground in a mortar with quartz sand in the cold in 5 volumes of a mixture of 0.15 M NaCl; 0.03 M sodium citrate; 0,05M Tris – HCl 8.0; 0.001 M EDTA. The resulting homogenate was mixed in the cold and centrifuged at 500 g for 15 min. The aqueous phase (extract 1) was decanted, and the sediment was re-extracted under these conditions. The combined aqueous-salt layer was again centrifuged at 10,000 g for 15 min. Sediment 2, containing chloroplasts, mitochondria, cell debris and other cytoplasmic particles, was discarded, and the supernatant was precipitated with two volumes of cold ethanol. Extraction of stable DNA. The residue after extraction of labile DNA (precipitate 1) was again homogenized in 6 volumes of a mixture of 0.6 M NaCl; 0.001 M EDTA; 0.05 M Tris-HCI pH 8.0; 2% PAS (sodium para-aminosalicylate); 0.5% SDS (sodium dodecyl sulfate). After 15 min of mixing and subsequent centrifugation at 2500 g, the upper (water-salt) layer was aspirated. The precipitate was washed again with the extractant and the combined aqueous phases were precipitated with two volumes of cold ethanol. Extraction of residual DNA. 0.6 M NaCl extracts the bulk of the cell DNA. However, some of the DNA, especially tightly bound in the cell structures, remains unrecovered. For complete extraction, the residue of plant tissue after stable DNA extraction was suspended in 6 volumes of a mixture of 0.18 MNaCl; 0.001 M EDTA; 0.02 M phosphate buffer pH 8.0; 5% PAS; 1% SDS. The temperature of the mixture was brought to 60 °C and maintained for 5 min, then cooled to room temperature. The centrifugate was precipitated with two volumes of cold ethanol.
Subsequent washing of the alcohol precipitate of DNA fractions was carried out in the following sequence:
The precipitate obtained after such treatment was dissolved in a minimum volume of 0.5 N NaOH and incubated for 18 hours at 37 °C. After the specified time, the hydrolysates were cooled and neutralized with 57% perchloric acid and acidified with it to pH 1.0. They were kept for 30 min (until the DNA precipitate was formed) and centrifuged at 12,000 g for 20-30 min. The centrifugate (RNA) was decanted, and the precipitate was washed again with 0.5 N HClO4. The centrifugates were combined and the amount of RNA was determined after hydrolysis. The precipitate was poured with 3-5 ml of 0.5 N HClO4, hydrolyzed for 20 min in a boiling water bath and, after cooling and making the appropriate dilution, spectrophotometered at wavelengths of 270 and 290 nm.
A certain role in identifying the traits that determine a form or variety in relation to its resistance to unfavorable environmental factors belongs to the physiological characteristics of the plant. The physiological response to stress is an emergency mobilization of the adaptive potential, ensuring temporary survival of adverse effects and, in this regard, having adaptive significance.. Since differences in the mechanisms of perception and transduction of stress signals in plants lead to different tolerance to stress, the study of the stress response allows us to identify the comparative degree of plant resistance to the action of abiotic environmental factors. Cotton is particularly sensitive to the effects of unfavorable environmental factors, and therefore has the least resistance, at the germination stage (Akparov et al., 2006). In this regard, we studied the adaptive potential of collection varieties of cotton in terms of seed germination under salt stress. The study of the degree of resistance of cotton samples to salinity showed that for different cotton varieties, due to genetic specificity, the influence of the stress factor is not the same. Depending on the genotype, variety samples of the same species differed significantly in the amplitude of the physiological parameter during adaptive processes. The reaction of variety samples to the action of unfavorable environmental factors allowed us to roughly divide variety samples into groups within the species, determining different degrees of comparative resistance.
Cluster Analysis of Resistance to Salinity of Cotton Variety Samples Is Presented in The Figure 1
Figure 1: Distribution of cotton varieties of the species G. barbadense L. by degree of resistance to salinity.
Highly resistant to stress cotton varieties were grouped in cluster 3. High resistance of cotton varieties to stress determines their ability to maintain a normal metabolic rate with a wider range of values of the unfavorable factor and a higher rate of development of protective metabolic changes. Resistant plants, compared to unstable ones, most fully rebuild their vital functions in the direction of adaptation to unfavorable environmental conditions. Unresistant plants under the influence of a negative environmental factor are more conservative and are not capable of quickly changing their vital functions, as a result of which they often die. Thus, as a result of the research it was established that with the same intensity of the extreme factor, the varieties of the same type of cotton differ significantly in the amplitude of the change in the physiological parameter, which made it possible to identify highly resistant and sensitive genotypes. The lever for implementing adaptive restructuring is the metabolic coordination system, ultimately controlled by the center of gene regulation of nuclear DNA, realized through the activity of enzymatic systems and limited by the energy potential of the cell and the organism as a whole. There is information in the literature that abiotic stressors express a multigene system (Kotak et al., 2007). Since each physiological mechanism is determined by its own gene complexes or blocks, it seemed important to us to study the nature of changes in the synthesis of nucleic acids and the fractional composition of DNA under stressful conditions in cotton varieties characterized by varying degrees of resistance to abiotic stress factors. As the results of the study showed, cotton varieties differed in their resistance to salt stress. The varieties AP-154, 9732I, 5010-V, Senare, S-6022 and S-6002 are highly resistant to salinity. Stress depression of seed germination in a salt solution is completely absent in these samples (Table 1). Under stress conditions, salt-tolerant varieties show activation of RNA synthesis, although to varying degrees, depending on the genotype of the plants. The increase in RNA content in the studied experimental varieties compared to the control plants ranged from 5.6 to 31.1%. For example, in the 9732I variety, the increase in RNA synthesis under salinity was 7.0%, and in the Senare variety, 20.9%. The structural state and functional activity of the DNA of the cell nucleus is heterogeneous (Konarev, 1970). Part of it is in a labile state as part of dispersed chromatin – euchromatin and is functionally more active. The DNA of labial chromatin is unsaturated with histones, has many free phosphate groups and metastable, easily denatured regions. The majority of DNA is tightly bound to histones and is a component of less active compact chromatin.. Stable chromatin belongs to metaphase chromosomes and compact structures of interphase chromosomes, including heterochromatin.. It is poor in non-histone proteins and RNA. DNA in stable chromatin is saturated with histones and relatively poor in free phosphate groups. A small part of DNA (perinucleolar chromatin) is firmly bound in chromatin due to special packaging in structures containing RNA and lipids in addition to proteins. Residual chromatin contains non-histone proteins that are common with labile chromatin but absent from stable chromatin. A study of the nature of nucleic acid synthesis and the fractional composition of DNA under salt stress showed that, in addition to RNA, stress-resistant varieties showed an increase in total and labile DNA. For example, in control plants of the Senare variety, the total DNA content was 16.102 mg%, labile DNA – 5.107 mg%, in experimental plants of this variety, the activation of the synthesis of these indicators was 6.611% and 6.215%, respectively. At the same time, salt-tolerant varieties show a decrease in the amount of stable DNA when exposed to salinity. For example, under stress, the percentage of stable DNA in the Senare variety decreases by 7.1%. The same picture is observed in other stress-resistant variety samples (figure 2). As for residual DNA, salt-tolerant samples showed an increase in its quantity. The only exception was the 9732I variety, in the experimental plant of which the decrease in residual DNA was 0.9%.
№ |
Varieties | Seed germination under salinity, in% | RNA, mg% | DNA, mg% | ||||||
| control | experience | in % of control | stress-depression, in % | control | experience | DNA fractions | control | experience | ||
| 1. | АР-154 | 76,0 | 76,0 | 100 | 0 | 105,0±4,35 | 137,63±1,29 | labile | 4,274±0,11 | 5,657±0,04 |
| stable | 7,209±0,04 | 6,310±0,09 | ||||||||
| residual | 1,224±0,06 | 1,472±0,06 | ||||||||
| total | 12,707 | 13,439 | ||||||||
| 2 | 9732I | 92,0 | 92,0 | 100 | 0 | 117,944±2,42 | 126,224±2,87 | labile | 5,506±0,11 | 5,941±0,08 |
| stable | 7,794±0,14 | 7,244±0,14 | ||||||||
| residual | 2,252±0,04 | 2,226 | ||||||||
| total | 15,552 | 15,411 | ||||||||
| 3. | 5010-V | 100 | 100 | 100 | 0 | 107,64±5,18 | 113,71±2,72 | labile | 5,595±0,07 | 6,207±0,09 |
| stable | 7,661±0,22 | 7,067±0,08 | ||||||||
| residual | 2,299±0,07 | 2,509±0,06 | ||||||||
| total | 15,555 | 15,783 | ||||||||
| 4. | Senare | 94,8 | 94,8 | 100 | 0 | 122,36±2,434 | 147,93±1,35 | labile | 5,107±0,08 | 6,215±0,15 |
| stable | 8,494±0,10 | 7,891±0,10 | ||||||||
| residual | 2,501±0,03 | 2,505± | ||||||||
| total | 16,102 | 16,611 | ||||||||
| 5. | S-6022 | 95,0 | 95,0 | 100 | 0 | 123,832±1,50 | 147,016±2,48 | labile | 5,187±0,08 | 6,242±0,05 |
| stable | 9,283±0,11 | 8,503±0,08 | ||||||||
| residual | 2,021±0,04 | 2,385±0,05 | ||||||||
| total | 16,491 | 17,130 | ||||||||
Table 1: Changes in seed germination, RNA content and DNA fractions in stress-resistant cotton varieties under salinity conditions.
AP-154 2. 97321 3.5010-V 4. Senare 5.S-6022
In cotton genotypes characterized by stress depression of seed germination in a saline solution, a decrease in the synthesis of RNA, total and labile DNA is observed in comparison with control plants (Table.2). Moreover, the more sensitive the plant was to salinity, the greater the decrease in RNA, total and labile DNA synthesis was. For example, stress depression of seed germination under salinity in variety 741 was 15%, depression of labile DNA synthesis in experimental plants, compared to the control, was 9.5%. In variety C-6040-1, depression of seed germination under stress was 49.2%, depression of labile DNA synthesis was 18.6%. At the same time, this process was accompanied by an increase in the amount of stable DNA (figure 3).
In adaptive metabolic restructuring, a major role is played by a more complete mobilization of the potential capabilities of various reactions, compensatory changes in associated processes, and the inclusion of shunt mechanisms (Udovenko, 1995). Under normal conditions, the intensity of various processes occurs at levels significantly lower than the maximum possible. Under unfavorable conditions, these capabilities are used more fully, which allows plants to maintain the speed of many reactions at a fairly high level. Differences between varieties in terms of resistance level are genetically determined and are hereditarily preserved over a number of generations. Since differences in the mechanisms of perception and transduction of the stress signal in plants lead to different tolerance to stress, the study of the stress response allows us to identify the comparative degree of plant resistance to the action of abiotic environmental factors. As a result of the studies, it was found that with the same intensity of the extreme factor, variety samples of the same cotton species differ significantly in the amplitude of the change in the physiological parameter. The amplitude of physiological parameters under stress depends on the level of plant resistance, which is an inherited potential ability of the organism to adapt and is realized under the action of an extreme factor. The reaction of the variety samples to the action of unfavourable environmental factors made it possible to divide the variety samples into groups within the species, determining different degrees of comparative resistance. In an unfavorable situation, the rapid response of plants is gene expression. A study of the expression of potential defense reaction genes in cotton showed that its regulation is more pronounced and occurs more quickly in the resistant variety (Cui, 2000). In our studies, the effect of stress on salinity-resistant cotton varieties causes activation of the synthesis of total, labile and residual DNA, as well as RNA, which indicates an increase in the physiological lability and functional activity of the genetic apparatus. Chromatin labilization is promoted by factors that stimulate growth and metabolic processes in the body. Despite the fact that the content of residual DNA in the total amount of the genome is the smallest, there is an assumption that it is metabolically active and plays a role in accelerating cell division (Konarev, 1970).
№ |
Сорта | Seed germination under salinity, in% | RNA, mg% | DNA, mg% | ||||||
| control | experience | in % of control | stress-depression, in % | control | experience | DNA fractions | control | experience | ||
| 1. | S-6002 | 92,0 | 86,8 | 94,3 | 5,7 | 109,48±2,55 |
102,304± 1,75 | labile | 4,699±0,02 | 4,501±0,11 |
| stable | 7,253±0,07 | 7,341±0,08 | ||||||||
| residual | 1,489±0,05 | 1,472±0,06 | ||||||||
| total | 13,417 | 13,314 | ||||||||
| 2 | 741 | 80,0 | 68,0 | 85,0 | 15,0 | 112,056±1,59 | 102,672±1,69 | labile | 4,859±0,08 | 4,398±0,11 |
| stable | 7,093±0,09 | 7,404±0,09 | ||||||||
| residual | 2,101±0,04 | 2,004±0,05 | ||||||||
| total | 14,053 | 13,806 | ||||||||
| 3. | 5904-1 | 78,5 | 58,5 | 74,5 | 25,5 | 120,152±1,44 | 104,328±2,40 | labile | 5,533±0,03 | 4,833±0,08 |
| stable | 7,652±0,08 | 8,007±0,06 | ||||||||
| residual | 2,341±0,03 | 1,986±0,02 | ||||||||
| total | 15,526 | 14,826 | ||||||||
| 4. | С-6040-1 | 73,2 | 37,2 | 50,8 | 49,2 | 125,304±2,60 | 101,752±1,22 | labile | 5,905±0,11 | 4,806±0,05 |
| stable | 8,406±0,08 | 7,767±0,06 | ||||||||
| residual | 2,500±0,05 | 2,013±0,07 | ||||||||
| total | 16,811 | 14,586 | ||||||||
Table 2: Changes in seed germination, RNA content and DNA fractions in stress-sensitive cotton varieties under salinity conditions.
Figure 3: Changes in nucleic acid synthesis under salinization in cotton varieties characterized by different sensitivity to stress.
1. С-6002 2. 741 3.5904-1 4.C-6040-1
The increase in the content of labile DNA and RNA in salt-tolerant cotton samples under stress indicates that stress-resistant genotypes exhibit an increase in the physiological lability of the genetic system. A positive change in the synthesis of labile, residual DNA and RNA in stress-resistant samples indicates an increase in the functional activity of the genome, which in turn ensures the acceleration of synthetic processes, especially protein synthesis, and thereby increases the body's resistance to stress factors. In stress-unstable samples, a decrease in RNA and DNA synthesis and a shift in the ratio of DNA fractions towards the stable one are observed. It is known that DNA stabilization is promoted by factors that inhibit growth and metabolic processes. Stable chromatin is not characteristic of the nuclei of embryonic cells capable of reproduction by mitosis. It usually accumulates most in the nuclei of cells in a state of rest, in seeds, dormant buds, etc. Depression in the development of stress-sensitive varieties is caused by changes in the structural state of total DNA and the functional activity of nuclear DNA - the transition from a loose (labile DNA) to a less active state tightly packed with histones (stable DNA). Blocking DNA with histones ensures its increase to unfavorable factors of influence. At the same time, in such a stabilized structural state, the functional activity of DNA decreases, in particular, its activity as a general regulator of synthetic reactions of metabolism. The obtained data on the change in the ratio of DNA fractions are consistent with the literature data on the study of the effect of cold stress on the change in the ratio of eu- and heterochromatin in the nuclei of soybean plant root cells (Stepinski, 2012). The author found that under cold conditions the fluorescence intensity for markers characteristic of heterochromatin increased, while for markers corresponding to euchromatin it decreased. After restoration of optimal conditions for plant growth, the opposite situation was observed, that is, an increase in the fluorescence intensity of markers corresponding to the euchromatic fraction and a decrease in the fluorescence intensity of markers corresponding to the heterochromatic fraction were noted. Thus, the data we have obtained indicate that stress factors affect the structure and functional activity of the plant genome. If this effect does not have a negative effect on stress-resistant varieties, then they have a negative effect on sensitive genotypes and cause degradation of nucleic acids, which leads to weakening of plants, decreased resistance and can even lead to the death of the plant.
The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.
The authors have no relevant financial or non-financial interests to disclose.
Ramiz Aliyev played a pivotal role in formulating the original research question and offering invaluable direction and guidance throughout the investigation. Afet Dadash Mammadova and Ramiz Aliyev conducted thorough data analysis and collaborated closely to write the manuscript. All authors read and approved the final manuscript.
All data generated during this research are included in this published article and its supplementary information files.
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"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
International Journal of Clinical Case Reports and Reviews is a high quality journal that has a clear and concise submission process. The peer review process was comprehensive and constructive. Support from the editorial office was excellent, since the administrative staff were responsive. The journal provides a fast and timely publication timeline.
Dear Maria Emerson, Editorial Coordinator of International Journal of Clinical Case Reports and Reviews, What distinguishes International Journal of Clinical Case Report and Review is not only the scientific rigor of its publications, but the intellectual climate in which research is evaluated. The submission process is refreshingly free of unnecessary formal barriers and bureaucratic rituals that often complicate academic publishing without adding real value. The peer-review system is demanding yet constructive, guided by genuine scientific dialogue rather than hierarchical or authoritarian attitudes. Reviewers act as collaborators in improving the manuscript, not as gatekeepers imposing arbitrary standards. This journal offers a rare balance: high methodological standards combined with a respectful, transparent, and supportive editorial approach. In an era where publishing can feel more burdensome than research itself, this platform restores the original purpose of peer review — to refine ideas, not to obstruct them Prof. Perlat Kapisyzi, FCCP PULMONOLOGIST AND THORACIC IMAGING.
Dear Grace Pierce, International Journal of Clinical Case Reports and Reviews I appreciate the opportunity to review for Auctore Journal, as the overall editorial process was smooth, transparent and professionally managed. This journal maintains high scientific standards and ensures timely communications with authors, which is truly commendable. I would like to express my special thanks to editor Grace Pierce for his constant guidance, promt responses, and supportive coordination throughout the review process. I am also greatful to Eleanor Bailey from the finance department for her clear communication and efficient handling of all administrative matters. Overall, my experience with Auctore Journal has been highly positive and rewarding. Best regards, Sabita sinha
Dear Mayra Duenas, Editorial Coordinator of the journal IJCCR, I write here a little on my experience as an author submitting to the International Journal of Clinical Case Reports and Reviews (IJCCR). This was my first submission to IJCCR and my manuscript was inherently an outsider’s effort. It attempted to broadly identify and then make some sense of life’s under-appreciated mysteries. I initially had responded to a request for possible submissions. I then contacted IJCCR with a tentative topic for a manuscript. They quickly got back with an approval for the submission, but with a particular requirement that it be medically relevant. I then put together a manuscript and submitted it. After the usual back-and-forth over forms and formality, the manuscript was sent off for reviews. Within 2 weeks I got back 4 reviews which were both helpful and also surprising. Surprising in that the topic was somewhat foreign to medical literature. My subsequent updates in response to the reviewer comments went smoothly and in short order I had a series of proofs to evaluate. All in all, the whole publication process seemed outstanding. It was both helpful in terms of the paper’s content and also in terms of its efficient and friendly communications. Thank you all very much. Sincerely, Ted Christopher, Rochester, NY.
