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Review Article | DOI: https://doi.org/10.31579/2690-8794/290
Department of Pharmaceutics, RBVRR Women’s College of Pharmacy, Barkatpura Hyderabad, India.
*Corresponding Author: Molgara Nikhila, Professor, Department of Pharmaceutics, RBVRR Women’s College of Pharmacy, Barkatpura Hyderabad, India.
Citation: Molgara Nikhila, A Krishna Sailaja, (2025), A Comprehensive Review on The Significance of Vesicular Drug Delivery Systems in Dermatological Therapy, Clinical Medical Reviews and Reports, 7(8); DOI:10.31579/2690-8794/290
Copyright: © 2025, Molgara Nikhila. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 09 October 2025 | Accepted: 24 October 2025 | Published: 10 November 2025
Keywords: systemic delivery; vesicular drug delivery; skin barriers; dermatological diseases; non-invasive therapy
Vesicular drug delivery systems (VDDS), including transferosomes, invasomes, and some advanced lipid vesicles, have revolutionized therapeutic approach for several dermatological diseases by enabling the efficient transdermal delivery of drugs and also the possibility for systemic action of the drug. The vesicle which is inact and the drug that is encapsulated into the vesicle can penetrate deeply into the dermis and potentially reach systemic circulation by surpassing the formidable barrier of the stratum corneum. Non-invasive systemic therapy for medications that were previously restricted to oral or injectable routes is facilitated by this dual ability, which also improves local bioavailability at the site of application. This review shows about the structural properties, the clinical outcomes of key vesicular systems alongwith its systemic-transdermal efficacy, their penetration methods mostly outlining the applications in treatment of chronic skin problems, hormonal therapy, pain, and systemic diseases.
Skin is the most accessible organ along with being the largest organ and it is the skin that mediates interaction between the human body and the outside world offering vital protective,sensory as well asregulatory functions. Nevertheless, the stratum corneum is the outermost layer and acts as a strong barrier which prevents majority of therapeutic substances from penetrating causing a reduction in the efficacy of topical therapies for a various dermatological condition. There is a need for a patient-friendly, efficient, and tailored treatment as traditional delivery techniques such as oral or injectables, generally have problems with hepatic first-pass metabolism, and systemic side effects, inadequate bioavailability [1-5].
A wide range of medication including both lipophilic and hydrophilic, can be encapsulated in vesicular systems that act as acutting-edge platformwhichprovides prolonged release and regulated release of the drug. By improving the permeability, the nanosized carriers including transethosomes, transferosomes, ethosomes and invasomesintendto penetrate skin barrier and also facilitate transportation of the drug into the deeper layers of the skin and also some amount into systemic circulation.
These systems act their best for delivery of the drug to both the local and systemic circulation in order to show a perfect effect for the treatment of variety of dermatological infections because of their versatility, including the deformability, penetration boosters like terpenes and ethanol and their capability toshield labile medications [6-10].
The organised, nanoscale assemblies of amphiphilic molecules make up the vesicular drug delivery systems (VDDS) are formed from one or more lipid bilayers when exposed to aqueous conditions. These provide flexible methodsfor the delivery of the drug for treatment of dermatological infections by encapsulating both hydrophilic and lipophilic medications where the hydrophilic drug gets encapsulated in the aqueous core while the lipophilic drug gets entrapped in the lipid bilayer. Some of the main systems which show their effect both trans dermally and systematically are as follows [11-13]
4.1 Invasomes
Structure: Invasomes are bilayered.The lipid bilayer when compared to liposomes has ethanol and terpenes which make the membrane less rigid, more soft and flexible.
Ethanol's role is to improve the fluidity of the lipid bilayer and it also interacts with lipids in the stratum corneum to break their densely packed structure and increase the permeability of the skin.
Terpene’s role is to penetrate the stratum corneum and destabilizing the lipid structure so that terpenes can improve its penetration into the skin.
Composition: Mainly composed of phospholipids, ethanol, one or more terpenes. They produce the flexible vesicleswhich are calledinvasomes.
Morphology: The size is generally bilamellar or unilamellarspherical vesicles varying between 90 and 150 nm, on the basis of amount of terpene included.These have distinct shape with small particle size allowing it to pass through the stratum corneum's intercellular gaps and enter the follicular pathways leading to both dermal and systemic absorption. Some of the terpenes which affect vesicle size are citral, eugenol, limonene, and cineole.
Penetration mechanism: They break down during penetration and produce phospholipid fragments and terpene molecules which improves permeability and fluidise the skin's lipids. Smaller intact invasomes use either the follicular pathway or tiny intercellular channels to enter the stratum corneum's deeper levels.
Delivery: These are useful for targeted transdermal delivery improving the therapeutic ability mainly because of composition that causes effective encapsulation of drugs leading to increased cutaneous and systemic absorption [14-16].
4.2 Transferosomes
Structure: These are havingbilayered lipid structure primarilyconsisting of phospholipids such as soy phosphatidylcholine or soy lecithin. These phospholipids can entrap the hydrophilicdrugs in the aquatic core to create flexible, spherical vesicles.
These include edge activators like single-chain surfactants such as sodium cholate, Tween 80, or Span 80 which are embedded into the phospholipid bilayer. These edge activators act as membrane softeners and show improvement in the bilayer's fluidity and elasticitymaking the vesicle extremely malleable.
Composition:Transferosomes are called as ultra-deformable vesicles and are generally made up of phospholipids along with an edge activator which are surfactants like sodium cholate, Span 80, Tween 80. These add flexibility to the vesicles.
This is a self-regulating vesicle which can adjust quickly to any kind of mechanical stress in the skin when phospholipids and surfactants are combined in the right amounts, allowing intact vesicle penetration into the deep skin layer.
Flexibility and Deformability: These can shrink and pass through skin pores and become almost 5 times smaller than their own size without being destroyed because of the edge activators.
Penetration mechanism: They enter the skin mainly via osmosis which is a moisture gradientdriven techniquewhere the vesicles movedeeper into the skin layers. They also combine with the lipid bilayers of the skin to release medications locally or promote systemic absorption [17-18].
4.3 Bilosomes
Structure: When compared to niosomes, these have a closed vesicle structure which is bilayer but are having difference in the part where bile salts are incorporated into the bilayer. Phospholipids like soy lecithin, soy phosphatidylcholine, non-ionic surfactants such as Span 80, Span 60, Span 40, Tween 80 andbile salts including sodium deoxycholate, sodium taurocholate as well as cholesterol make up most of the lipid bilayer.
Bile salts: They play a role in improving the deformability of vesicles along with its flexibility as they actas edge activators. These bile saltsimprove membrane permeability and alsostabilise the vesicular membrane against harsh environment as that of the one present in gastrointestinal tract facilitating systemic absorption following oral and topical application.
Surfactants and Cholesterol: Non-ionic surfactants are added in order to control the vesicular size, permeability, encapsulation effectiveness.Whereas the cholesterol used here is generally added to update the lipid bilayer rigidity and stability.
Morphology: Most of functional bilosomes are of nano-sized 100–200 nm while its vesicle size ranges between 90 nm to 3 mm. Studies which are using transmission electron microscopy and dynamic light scattering prove that these are having smooth spherical shape and show great colloidal stabilityeven in a cold environment.
Encapsulation of drug: The flexible nature of these says that even sensitive biological components and some of the challenging hydrophobic compounds remain intact during transport and while drug entrapment occurs therefore proving that it protects the encapsulated drugs from adverse environmental conditions like stomach acids, enzymes in both oral and topical dosage forms [19]
4.4 Transethosomes
Structure: They are built around the common phospholipid bilayer made of lecithin or soybean phosphatidylcholine. The bilayer has a polar or hydrophilic group which is head and a non polarhydrophobic group which is tail.
Function of Ethanol: It is used in high concentration and thus improves penetration by lipid bilayer fluidization and also the lipids present in the skin allowing for more effective and deeperdelivery.
Edge activators: For seeing a further improvement in the membrane elasticity these edge activators are combined with ethanol and added. This causesvariation in transethosomes from other systems enabling it to pass through tiny pores of skin.
Morphology: These are smooth and spherical nanosized vesicles ranging from 90–170 nm obtained on the basis of transmission electron microscopy (TEM) and scanning electron microscopy (SEM) data. Both the ethanol 30–40%and the edge activator like sodium cholate span 80tween 80 differentiate these from other systems.
Ultra-Deformability: These systems show a greater deformability compared to transferosomes and ethosomes because of the cooperation and a combined effect shown by phospholipids, edge activators, ethanol [20].
| Vesicular system | Method | Disease | Organism | Symptoms | Systemic effect | Therapeutic role |
| Invasomes | Ethanol injection or thin film hydration | Onychomychosis, Lyme disease | Trichophyton rubrum, Borrelia burgdorferi | Erythema migranschronic plaques | Joint, cardiac and nervous effect | Deeper penetration for systemic and local action |
| Transferosome | Thin film hydration | Herpes simplex lesions, Staphylococcal Scalded Skin Syndrome | Herpes simplex virus, Staphylococcus aureus | Fragile blisters,desquamation,erythema | Multiorgan failure, fever, Malaise,myalgia | Antibiotic,antiviral transdermal administration enters systemic circulation |
| Bilosomes | Reverse phase evaporation, thin film hydration | Cutaneous Cryptococcosis, Blastomycosis, Candidiasis | Cryptococcus, Blastomyces, Candida | Abscesses, ulcers plaques, cellulitis | Lung infections, CNS effects | Local and systemic administration of antifungal drugs with more stability |
| Transethosome | Ethanol injection, thin film hydration | Pyoderma gangrenosum | Immune factors, enetric bacteria | Ulcers, fever, sores, arthralgia, | Systemic inflammation, abdominal pain | systemic,local administration of immunomodulators and corticosteroids with improved penetration |
Vesicular Systems and Its Role
| Systems | Therapeutic significance | Local action | Systemic action |
Transferosomes |
Drug loading is high, deformability is maximum, shows effects on deeper structures |
Vesicles physically cross barrier, site specific action, hydration of skin increases |
Effective as carriers for proteins and peptides, delivery of huge therapeutic agents |
| Transethosomes | Combines parts of ethosome transferosomes to form flexible vesicles lets drugs pass better making it more stable. | Ethanol- fluidizes membrane Edge activators-vesicle deformation, improved bioavailability | These squeeze intactly through pores of skin causing drugs to enter dermis and epidermis as well as systemic circulation. |
| Cubosomes | High therapeutic load, delivery in a controlled way, cubic symmetry in a nanoscale manner | Target site of lesions on skin Anti-inflammatory action-extended release on inflamed areas of skin | Cubic lipid nano structure assists in constant drug levels for longer time, no first pass metabolism |
| Invasomes | Flexible, vesicle deformation enhanced skin penetration Terpenes-fludize bilayer | Maximum intradermal release
| Disruption of stratum corneum,improving flexibility of vesicle, large molecule transport |
Vesicular System and Its Significance
7.1 Invasomes
Invasomes are the natural agents which momentarily loosen those fortress's bricks that is the lipid layers of the skin without actually causingany damage. These have similarity with that of a discreet penetrator containing molecular agents like terpenes and ethanol. Due to their versatile, phospholipidcomposition that acts as a backbone, these can infiltrate profoundly into the skin barrier and be able to deliver both hydrophilic and lipophilic drugs to the targeted cells which require it the most without causing any other systemic side effects or distractions. These consists of terpenes, phospholipid as well as ethanolthat together disturb and fluidise the lipid bilayers of the skins outermost layer stratum corneum.Invasomes deformation ability combined with its extra small size helps it to penetrate while intact and improve the intradermal release of the drug while reducing the systemic exposure[21].
7.2 Transferosomes
These act as super flexible vehicles using the osmotic water gradient as a resourceful guide to change its shape to be able to fit and pass through small openings of skin. These vesicles stay stable throughout and carry the drugs mostly high weight compounds like proteins and peptides that are typically difficult to deliver within the skin layers. Phospholipids and edge activators like surfactants generally disorganize the lipid layer in order toenhance the flexibility of the membrane can be found in this vesicular system.The osmotic gradient helps in driving the transferosomes further deep into the skins lipid layers and simultaneously releasing the drug exactly at targeted site and in some cases helps in systemic absorption if required.
7.3 Transethosomes
Transethosomes are at the frontline of novel vesicular drug delivery systems as they have a combination of two effective and robust mechanisms which is the exceptional deformability because of the use of edge activators and also the interference of skin lipids because of the ethanol. This duo makes it feasible for these systems to effectively penetrate the skinbarrier causing an improved local effect at its targeted site of action and alsosystemic absorption. The technique of transethosomes helps in bypassing the first-pass metabolism which is a major issue in the case of oral drugs providing a non-invasiveroute for systemic treatment with increased bioavailability and diminishedorgan toxicity [22].
7.4 Cubosomes
Cubosomes are the nanostructured particles having 3D honeycomb lipid matrix. These have an excellent bioadhesion that is its interaction with skin. This is made possible because of itsstructur which issimilar to that of the outer layer of skin that is stratum corneum. These are having large surface area as well as nano size that enablesit for efficient penetration.Because of its structurecubosomes have the ability for deeper dermal diffusion of the encapsulated drug which includes both hydrophilic andlipophilic and sometimes even amphiphilic components.These are alsohaving the ability to provide sustained and prolonged release of the drug and protect soem of the labile drugs from exposing to harmful environments and avoid degradation. Cubososmes also improve the therapeutic efficiency of the medication and also show systemic action.
Overall, these vesicular drug delivery systems have the ability to mimic the structure and alter the penetration ability and amplify it and also cause the physical deformationto promote the passage of the medications through the complex skin barrier and ensure a reliable delivery [23].
Therapeutic Applications in Dermatology
8.1 Invasomes
Efficient administration of immunosuppressants for inflammatory skin conditions such as psoriasis. The phospholipids ethanol and terpenes which are present combine and work together to provide invasomes remarkable skin permeation.Because of their deep penetration into the skin immunosuppressants and alsoantioxidants can be given which are very useful in the tratmentof inflammatory skin conditions, psoriasis, and in some cases acne. This increased penetration ability and deformation abilityincrease local therapy and systemic exposure.
8.2 Transferosomes
Due of its extremely flexible membrane that ispropelled by the skin moisture gradient these are show an exceptional delivery of high weight molecules like that of peptides and proteins. They transport drug which is still intact into the deeper skin layer which is dermis making it optimal for treatment of dermatological infections like eczema, psoriasis, atopic dermatitis,skin inflammation, chronic wounds. Transferosomes maintain localisedlevels of drugs and lower dose frequency along with increasing the patient compliance they can also improve the analgesic and the corticosteroid therapy for diseases like psoriasis and dermatitis.
8.3 Transethososmes
Transethosomes are the vesicles having excellent flexibility and enhancrd penetration ability by using the combination of edge activators along with high ethanol. They have shown immense outcomes in treating inflammatory conditions such as psoriasis or eczema some fungal infections in the case of candidiasis and dermatophytosisand some skin malignancies like squamous cell carcinoma or melanoma. It has the ability to deliver biomolecules and alsotiny medication transdermallyby improving the systemic bioavailability without a serious risk of causing toxicity. These act as a robustsystem in dermatological therapy as their capability to administer anticancer drugs dermally and alsoproviding a non-invasive technique for treating melanoma.
8.4 Cubososmes
Melanoma, psoriasis, cutaneous candidiasis, acne, vitiligo,alopecia are some of the skin conditions which can be treated by using this vesicular delivery system that is cubosomes. There is an increasing usage of cubososmes for the treatment of skin diseases with the benefit of prolonged drug release. Theseregulate a medication's time period on the skin and preventing it from deteriorating and by enhancing the therapeutic effectiveness. They are effective for skin care and disease management since studies have shown that they are beneficial in wound healing, antibacterial treatments, and improving the effectiveness of topical and systemic drug in dermatology [24-25].
As they allow for both systemic and local delivery of the drug through the skin vesicular drug delivery systems like cubosomes, bilososmes, invasomes, transferosomes, transethosomes becamerevolutionary systems in dermatological therapy. They can easily pass through the skin’s outermost layer that is the stratum corneum barrier because of theirexceptional compositions and remarkable flexibility that promotes the targetedpenetration of the medication, prolonged retention,sustained and controlled releaseand alsoincreased bioavailability. Countless dermatological infections that include acne, eczema, psoriasis, chronic wounds, fungal infections and in some cases melanomaand other skin malignancies arefruitfully treated with the help of these systems. They offer customised local delivery of drug reducing the systemic exposure and alsotoxicity while simultaneouslyaugmenting the therapeutic ability. These vesicular systems also have the capability to bypass the hepatic first-pass metabolism and improve the patient compliance. Certain specific vesicular delivery systems liketransethosomes, transferosomes show non-invasive absorption of drugs even for the macromolecules such as peptides and proteins. These vesicular systems that act as carriers have the potential to redefine the therapeutic strategies in the treatment of dermatological infections by combining the benefits of low side effects, goodbiocompatibility, different drug loading capability for both hydrophilic and hydrophobic medicines. Massformulation and stability issues still exist till now but there has been a continuous research development regarding the nanocarriers. Ultimately vesicular drug delivery systems play a vital role in the improvement of the treatment of dermatological diseases that will improve the outcomes and quality of life.
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My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
